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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 3 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 4 | Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or inteaocular lymphoma or intraocular lymphoma显示文摘 | SOUSSAIN C SUZAN F HOANG-XUAN K | 2001 | J Clin Oncol2001，19，： | 1 |
| 5 | Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma显示文摘 | Suzan F Hoang-Xuan K | 2001 | J Clin Oncol2001，19，： | 1 |
| 6 | Implementing physical best in higher education courses显示文摘 | Suzan F Ayers Ray D Martinez | 2007 | Journal of Physical Education Recreation& Dance2007，78，7： | 1 |
| 7 | Implementing Physical Best in Higher Education Courses 显示文摘 | Suzan F Ayers Ray D Martinez | 2007 | Journal of Physical Education Recreation & Dance Reston 20072007，78，7： | 1 |
| 8 | Serum CEACAM1 correlates with disease progression and survival in malignant melanoma patients显示文摘 | Sivan S Suzan F Rona O | 2012 | Clin Dev Immunol2012，35，2： | 1 |
| 9 | Fatal reactivation ofcyto-megalovirus infection after use of rituximab for a posttransplantation lymphoproliferative disorder显示文摘 | Suzan F Ammor M Ribrag V | 2001 | N Engl J Med2001，345，13： | 1 |
| 10 | Results of intensive chemotherapy followed by hematopoietee stem-cell rescue in 22 pa- tients with refractory or reemrent primal7 CNS lymphoma or intraocu- lar lymphoma 显示文摘 | Soussain C Suzan F Hoang-Xuan K | 2001 | J Clin Oncol2001，19，3： | 1 |
| 11 | Serum CEACAM1 correlates with disease progression and survival in malignant melanoma patients显示文摘 | Sivan S Suzan F Rona O | 2012 | Clin Dev Immunol2012，2012，29： | 1 |
| 12 | Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22patients with refractory or recurrent primary CNS lymphoma or inteaocular lymphoma or intraocular lymphoma显示文摘 | Soussain C Suzan F Hoang-Xuan K et a1 | 2001 | J Clin On-col2001，19，： | 1 |
| 13 | Bats are a major natural reservoir for hepaeiviruses and pegiviruses显示文摘 | Quan P L Firth C Conte J M Williams S H Zam- brana-Torrelio C M Anthony S J Ellison J A Gilbert A T Kuzmin I V Niezgoda M Osinubi M O Re-cuenco S Markotter W Breiman R F Kalemba L Malekani J Lindblade K A Rostal M K Ojeda-Flores R Suzan G Davis L B Blau D M Ogunkoya A B Alvarez Castillo D A Moran D Ngam S Akaibe D Agwanda B Briese T Epstein J H Daszak P Rup- precht C E Holmes E C Lipkin W I | 2013 | PNAS2013，110，20： | 1 |
| 14 | A new member of the immunoglobulin superfam-ily CTLA-4显示文摘 | Brunet JF Denizot F Luciani MF Roux-Dosseto M Suzan M Mattei MG | 1987 | Nature1987，328，6127： | 1 |
| 15 | Motality in 13 French cities during the August 2003 heat wave显示文摘 | Vandentorren S Suzan F Medina S | 2004 | American Journal of Public Health2004，94，： | 1 |
| 16 | Long-term complete haemato- logical and molecular remission after allogeneie bone marrow trans- plantation in a patient wilh a stem cell myeloproliferative disorder associated with t (8 ; 13 ) ( p l 2 ; q12 ) 显示文摘 | Suzan F Guasch G Terre C | 2003 | Br J Haematol2003，121，2： | 1 |
| 17 | Mortality in 13 French cities during the August 2003 Heat Wave显示文摘 | Vandentorren S Suzan F Medina S | 2004 | Am J Public Health2004，94，： | 1 |
| 18 | Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma显示文摘 | Suzan F Hoang-Xuan K | 2001 | J Clin Oncol2001，19，： | 1 |
| 19 | Results of intensive chemotherapy followed by hematopoietic stem cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma显示文摘 | Sonssain C Suzan F Hoang-Xuan K | 2001 | J Clin Oncol2001，19，3： | 1 |
| 20 | Anthracyclines,mitoxantrone,radiotherapy,and granulocyte colony-stimulating factor:risk factors for leukemia and myelodysplastic syndrome after breast cancer显示文摘 | Le Deley MC Suzan F Cutuli B | 2007 | J Clin Oncol2007，25，3： | 1 |
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