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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 3 | Potential impact of climatic change on the distribution of forest herbs in Europe显示文摘 | Skov F Svenning J C | 2004 | Ecography2004，27，： | 1 |
| 4 | Management and outcome of patients with combined bile duct and hepatic arterial injuries after laparoscopic cholecystectomy显示文摘 | Sven C Schmidt Ulz Settmacher Jan M Langrehr P Neuhaus | 2004 | Surgery2004，，6： | 1 |
| 5 | RFID tags for identifying and verifying agrochemicals in food traceability systems显示文摘 | Peers Sven Gasparin C P Blackburn D W K etal | 2009 | Precision Agric2009，，10： | 1 |
| 6 | Risk factors for acute re- spiratory morbidity in moderately preterm infants 显示文摘 | Maria A Mireille V Sven C | 2013 | Paediatr Perinat Epidemiol2013，27，2： | 1 |
| 7 | Random Forests as a Tool for Ecohydrological Distribution Modelling显示文摘 | Jan P Bernard D B Niko E C V Roeland S Sven D Piet D B Willy H | 2007 | Ecological Modelling2007，207，24： | 1 |
| 8 | Organic-inorganic interactions and sandstone diagenesis显示文摘 | Surdam R C Crossey L J Sven Sven E | 1989 | AAPG Bulletin1989，73，1： | 1 |
| 9 | Sensitivity of the Penman-Monteith reference evapotranspiration to key climatic variables in the Changjiang (Yangtze River) basin显示文摘 | Gong L B Xu C Y Sven H | 2006 | Journal of Hydrology2006，329，： | 1 |
| 10 | Diversity and dominance in palm (Arecaceae) communities in Terrafirme forests in the western Amazon basin 显示文摘 | Vormisto J Svenning J C Hall P | 2004 | Journal of Ecology2004，92，： | 1 |
| 11 | Oversto- rey control of understorey species composition in a near-natu- ral temperate broadleaved forest in Denmark显示文摘 | THOMSEN R P SVENNING J C BALSLEV H | 2005 | Plant Ecol- ogy2005，181，1： | 1 |
| 12 | Organ- ic-inorganic interactions and sandstone diagenesis 显示文摘 | Surdam R C Crossey L J Sven Hagen E | 1989 | AAPG Bulletin1989，73，： | 1 |
| 13 | Antigenic re-sponse of whey proteins and genetic variants ofβ-lactoglobulin-the effect of proteolysis and processing显示文摘 | Svenning C Brynhildsvold J Molland T | 2000 | International DairyJournal2000，10，： | 1 |
| 14 | Population ecology and conservation status of the last natural population of English yew Taxus baccata in Denmark 显示文摘 | Svenning J C Magard E | 1999 | Biological Conservation1999，8，： | 1 |
| 15 | Anthropogenic disturbance shapes phylogenetic and functional tree community structure in a subtropical forest显示文摘 | Feng G Svenning J C Mi X C | 2014 | Forest Ecology and Management2014，313，： | 1 |
| 16 | Topological properties of citatoin and metabolic networks显示文摘 | Sven Bilke Peterson C | | arxiv:cond-mat/01033610，，01： | 1 |
| 17 | A clinical histologic study of bovine hydroxyapatite in combination with autogenous bone and fibrin glue for maxillary sinus floor augmentation: results after 6 to 8 months of healing显示文摘 | Mats H Andreas C Sven L | 2001 | Clin Oral Implants Res2001，12，2： | 1 |
| 18 | Workflow View Driven Cross-Organizational Interoperabillty in a Web Service Environment显示文摘 | Dickson K W Cheung S C Sven T etc | 2004 | Information Technology and Management2004，5，34： | 1 |
| 19 | Leader-followerequilibria for electric power and NOa: allowances markets 显示文摘 | YIHSU C BENJAMIN F H SVEN L | 2006 | Computational Management Science2006，3，4： | 1 |
| 20 | Cesarean section delivery in the 1980's:international comparison by indication显示文摘 | Francix C N Sven Cnattingius | 1994 | Am J Obstet Gynecol1994，170，2： | 1 |
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