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| 1 | Chronic Epstein-Barr virus-related hepatitis in immunocompetent patients显示文摘AIM: To investigate reactivated Epstein-Barr virus (EBV) infection as a cause for chronic hepatitis. METHODS: Patients with occasionally established elevated serum aminotransferases were studied. HIV, HBV and HCV-infections were excluded as well as any other immunosuppressive factors, metabolic or toxic disorders. EBV viral capsid antigen (VCA) IgG and IgM, EA-R and EA-D IgG and Epstein-Barr nuclear antigen (EBNA) were measured using IFA kits. Immunophenotyping of whole blood was performed by multicolor flow cytometry. CD8+ T cell responses to EBV and PHA were determined according to the intracellular expression of IFN-γ. RESULTS: The mean alanine aminotransferase (ALT) and gamma glutamyl transpeptidase (GGTP) values exceeded twice the upper normal limit, AST/ALT ratio < 1. Serology tests showed reactivated EBV infection in all patients. Absolute number and percentages of T, B and NK cells were within the reference ranges. Fine subset analysis, in comparison to EBV+ healthy carriers, revealed a significant decrease of naive T cells (P < 0.001), accompanied by increased percentage of CD45RA- (P < 0.0001), and terminally differentiated CD28-CD27- CD8+ T cells (P < 0.01). Moderately elevated numbers of CD38 molecules on CD8+ T cells (P < 0.05) proposed a low viral burden. A significantly increased percentage of CD8+ T cells expressing IFN-γ in response to EBV and PHA stimulation was registered in patients, as compared to controls (P < 0.05). Liver biopsy specimens from 5 patients revealed nonspecific features of low-grade hepatitis.CONCLUSION: Chronic hepatitis might be a manifestation of chronic EBV infection in the lack of detectable immune deficiency; the expansion of CD28- CD27- and increase of functional EBV-specific CD8+ T cells being the only surrogate markers of viral activity. | Mihaela Petrova Maria Muhtarova Maria Nikolova Svetoslav Magaev Hristo Taskov Diana Nikolovska Zahariy Krastev | 2006 | World Journal of Gastroenterology2006，12，35： | 6 |
| 2 | Multi-year analyses on three populations reveal the first stable QTLs for tolerance to rain-induced fruit cracking in sweet cherry (Prunus avium L.)显示文摘Rain-induced fruit cracking is a major problem in sweet cherry cultivation.Basic research has been conducted to disentangle the physiological and mechanistic bases of this complex phenomenon,whereas genetic studies have lagged behind.The objective of this work was to disentangle the genetic determinism of rain-induced fruit cracking.We hypothesized that a large genetic variation would be revealed,by visual field observations conducted on mapping populations derived from well-contrasted cultivars for cracking tolerance.Three populations were evaluated over 7–8 years by estimating the proportion of cracked fruits for each genotype at maturity,at three different areas of the sweet cherry fruit:pistillar end,stem end,and fruit side.An original approach was adopted to integrate,within simple linear models,covariates potentially related to cracking,such as rainfall accumulation before harvest,fruit weight,and firmness.We found the first stable quantitative trait loci(QTLs)for cherry fruit cracking,explaining percentages of phenotypic variance above 20%,for each of these three types of cracking tolerance,in different linkage groups,confirming the high complexity of this trait.For these and other QTLs,further analyses suggested the existence of at least two-linked QTLs in each linkage group,some of which showed confidence intervals close to 5 cM.These promising results open the possibility of developing marker-assisted selection strategies to select cracking-tolerant sweet cherry cultivars.Further studies are needed to confirm the stability of the reported QTLs over different genetic backgrounds and environments and to narrow down the QTL confidence intervals,allowing the exploration of underlying candidate genes. | Jose Quero-Garcia Philippe Letourmy Jose Antonio Campoy Camille Branchereau Svetoslav Malchev Teresa Barreneche Elisabeth Dirlewanger | 2021 | Horticulture Research2021，8，1： | 3 |
| 3 | Pembrolizumab-emerging treatment of pulmonary sarcomatoid carcinoma: A case report显示文摘BACKGROUND Few studies have addressed the efficacy of pembrolizumab in pulmonary sarcomatoid carcinoma(PSC),a rare,previously rapidly fatal subtype of nonsmall-cell lung cancer.CASE SUMMARY We report the case of a 69-year-old man presented with respiratory distress caused by a large left upper lung lobe mass diagnosed as PSC with programmed death-ligand 1 expressed on more than 50 percent of tumor cells.The patient was started on pembrolizumab and,after 5 cycles,there was a more than 80 percent decrease in the size of the tumor mass.Further decrease was seen at the end of 10 cycles.The patient has been tolerating pembrolizumab well,with no limiting side-effects.Fourteen months after first coming into the hospital,he remains asymptomatic.CONCLUSION Pembrolizumab appears as a viable emerging treatment for PSC. | Emanuela Cimpeanu Jibran Ahmed Wahib Zafar Adreana DeMarinis Svetoslav S Bardarov Shamim Salman Dennis Bloomfield | 2020 | World Journal of Clinical Cases2020，8，1： | 2 |
| 4 | An Iterative Method for Algebraic Solutionto Interval Equations 显示文摘 | Markov Svetoslav | 1999 | Applied Numerical Mathematics1999，，30： | 1 |
| 5 | Synthesis and bioassay of improved mosquito repellents predicted from chemical structure显示文摘 | Katritzky A R Zuoquan W Svetoslav S | 2008 | Proceedings of the National Academy of Sciences of the USA2008，105，21： | 1 |
| 6 | Bacteriocin production by PediOCOCCUS pentosaceus isolated from marula(Scerocarya birrea)显示文摘 | Svetoslav D Todorov Leon M T | 2009 | International Journal of Food Microbiology2009，132，： | 1 |
| 7 | Bacteriocin produc- tion by Pediococcus pentosaceas isolated from marula( Scer- ocarya birrea)显示文摘 | Svetoslav D Todorov Leon M T Dicks | 2009 | International Journal of Food Microbi- ology2009，132，23： | 1 |
| 8 | Bacteriocinogenic Lactobacillus plantarum ST16Pa iso-lated from papaya(Carica papaya)-from isolation to application:Characterization of a bacteriocin显示文摘 | Svetoslav D Todorov Herr6 Pr6vost Martine Lebois | | 0，，： | 1 |
| 9 | Lyudmil nakovantichlamydial and antisperm antibodies in patients with chlamydial infections显示文摘 | Dimitrina D Svetoslav K Lyubomir H | 2004 | American Journal of Reproductive Immunology A JRI2004，52，： | 1 |
| 10 | Bacteriocinogenic Lactobacillus plantarum ST16Pa isolated from papaya (Carica papaya )-From isolation to application: characterization of a bacteriocin显示文摘 | Svetoslav DT Martine L Xavier D | 2011 | Food Research Internation- al2011，44，5： | 1 |
| 11 | A real-time procedural shading system for programmable graphics hardware显示文摘 | Kekoa Proudfoot William R Mark Svetoslav TzvetKovy | 2001 | ACM SIGGRAPH2001，，8： | 1 |
| 12 | Bacteriocinogenic Lactobacillus plantarum ST16Pa isolated from papaya ( Carica papaya) — From isolation to application: Characterization of a bacteriocin显示文摘 | Svetoslav D. Todorov Hervé Prévost Martine Lebois Xavier Dousset Jean Guy LeBlanc Bernadette D.G.M. Franco | 2011 | Food Research International2011，，5： | 1 |
| 13 | Impulsive controllability and optimization problems in population dynamics显示文摘 | Svetoslav I Nenov | 1999 | Nonlinear Analysis TMA1999，，36： | 1 |
| 14 | Hierarchical modeling of the elastic properties of bone at submicron scales: The role of extrafibrillar mineralization 显示文摘 | Svetoslav Nikolov Dierk Raabe | 2008 | Biophys J2008，94，11： | 1 |
| 15 | Light and electron microscopic study of the medial collateral ligament epiligament tissue in human knees显示文摘AIM To examine the normal morphology of the epiligament tissue of the knee medial collateral ligament(MCL) in humans. METHODS Several samples of the mid-substance of the MCL of the knee joint from 7 fresh human cadavers(3 females and 4 males) were taken. Examination of the epiligament tissue was conducted by light microscopy and photomicrography on semi-thin sections of formalin fixed paraffin-embedded blocks that were routinely stained with haematoxylin and eosin, Mallory stain and Van Gieson's stain. Electron microscopy of the epiligament tissue was performed on ultra-thin sections incubated in 1% osmium tetroxide and contrasted with 2.5% uranyl acetate, lead nitrate, and sodium citrate.RESULTS The current light microscopic study demonstrated that the epiligament of the MCL consisted of fibroblasts, fibrocytes, adipocytes, neuro-vascular bundles and numerous multidirectional collagen fibers. In contrast, the ligament body was poorly vascularised, composed of hypo-cellular fascicles which were formed of longitudinal groups of collagen fibers. Moreover, most of the vessels of the epiligament-ligament complex were situated in the epiligament tissue. The electron microscopic study revealed fibroblasts with various shapes in the epiligament substance. All of them had the ultrastructural characteristics of active cells with large nuclei, well developed rough endoplasmic reticulum, multiple ribosomes, poorly developed Golgi apparatus, elliptical mitochondria and oval lysosomes. The electron microscopy also confirmed the presence of adipocytes, mast cells, myelinated and unmyelinated nerve fibers and chaotically oriented collagen fibers.CONCLUSION Significant differences exist between the normal structure of the ligament and the epiligament whose morphology and function is to be studied further. | Georgi P Georgiev Alexandar Iliev Georgi Kotov Plamen Kinov Svetoslav Slavchev Boycho Landzhov | 2017 | World Journal of Orthopedics2017，8，5： | 1 |
| 16 | An iterative method for algebraic solution to interval equations 显示文摘 | Svetoslav Markov | 1999 | Applied numerical mathematics1999，，30： | 1 |
| 17 | Identification of lactic acid bacteria and yeast from boza 显示文摘 | Angela Botes Svetoslav D Todorov Johan W yon Mollendorff | 2007 | Process biochemistry2007，42，： | 1 |
| 18 | An iterative method for algebraic solution to interval equations显示文摘 | | 1999 | Applied Numerical Mathematics1999，30，23： | 1 |
| 19 | Characterization of two bacteriocins produced by Pediococcus acidilactici isolated from “Alheira”, a fermented sausage traditionally produced in Portugal显示文摘 | Helena Albano Svetoslav D. Todorov Carol A. van Reenen Tim Hogg Leon M.T. Dicks Paula Teixeira | 2007 | International Journal of Food Microbiology2007，，2： | 1 |
| 20 | Synthetic aperture ultrasound imaging显示文摘 | Jrgen Arendt Jensen Svetoslav Ivanov Nikolov Kim Lkke Gammelmark | 2006 | Ultrasonics2006，44，： | 1 |
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