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| 1 | Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test显示文摘AIM:To study intestinal permeability(IP) and its relationship to the disease activity in patients with inflammatory bowel diseases(IBD)-Crohn's disease(CD) and ulcerative colitis(UC).METHODS:Fifty-eight patients with active IBD(32 with CD and 26 with UC) and 25 healthy controls consented to participate in the study.The clinical activity of CD was estimated using the Crohn's Disease Activity Index(CDAI),and the endoscopic activity of UC using the Mayo scoring system.IP was assessed by the rise in levels of iohexol,which was administered orally(25 mL,350 mg/mL) 2 h after breakfast.Three and six hours later serum(SIC mg/L) and urine(UIC g/mol) iohexol concentrations were determined by a validated HPLC-UV technique.RESULTS:In the CD group,SIC values at 3 h(2.95 ± 2.11 mg/L) and at 6 h after ingestion(2.63 ± 2.18 mg/L) were significantly higher compared to those of healthy subjects(1.25 ± 1.40 mg/L and 1.11 ± 1.10 mg/L,respectively,P < 0.05).UIC(g/mol) values were also higher in patients,but the differences were significant only for UIC at 6 h.Significant positive correlation(P < 0.05) was found between the CDAI and IP,assessed by SIC at 3 h(r = 0.60) and 6 h(r = 0.74) after the ingestion.In comparison to controls,SIC and UIC of UC patients were higher in the two studied periods,but the differences were significant at 6 h only.Significantly higher values of SIC(P < 0.05) were found in patients with severe endoscopic activity of UC compared to those of patients with mild and moderate activity(3.68 ± 3.18 vs 0.92 ± 0.69 mg/L).CONCLUSION:Serum levels of iohexol at 3 h and 6 h after its ingestion reflect increased IP,which is related to the disease activity in patients with IBD. | Vanya A Gerova Simeon G Stoynov Dimitar S Katsarov Dobrin A Svinarov | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 2 | Simultaneous determination of mycophenolic acid and its phenolic glucuronide in human plasma using an isocratic high-performance liquid chromatography procedure显示文摘 | Indjova D Kassabova L Svinarov D | 2005 | J Chromatogr B Analyt Technol Biomed Life Sci2005，817，2： | 1 |
| 3 | Prevalence of vitamin D deficiency and insufficiency in Bulgarian patients with chronic Hepatitis C viral infection显示文摘 | Daniela Ivanova Gerova Bistra Tzaneva Galunska Irina Ivanova Ivanova Iskren Andreev Kotzev Trifon Georgiev Tchervenkov Svetlozar Petrov Balev Dobrin Avramov Svinarov | 2014 | Scandinavian Journal of Clinical & Laboratory Investigation2014，，8： | 1 |
| 4 | Cyclosporin whole blood immunoassays ( AxSYM, CEDIA, and Emit): a critical overview of performance characteristics and comparison with HPLC显示文摘 | Schutz E Svinarov D Shipkova M | 1998 | Clin Chem1998，44，10： | 1 |
| 5 | Cyclosporin whole blood immunoassays(AxSYM,CEDIA,and Emit) :a critical overview of performance characteristics and comparison with HPLC显示文摘 | Schutz E Svinarov D Shipkova M | 1998 | Clin Chem1998，44，： | 1 |
| 6 | Cyclosporin whole blood immunoassays ( AxSYM, CEDIA, and Emit ) : a critical overview of performance characteristics and comparison with HPLC 显示文摘 | SEHAU E SVINAROV D SHIPKOVA M | 1998 | Clin Chem1998，44，10： | 1 |
| 7 | Cyclosporin whole blood immuno-assays (AxSYM,CEDIA,and Emit):a critical overview of performance characteristics and comparison with HPLC显示文摘 | Schutz E Svinarov D Shipkova M | 1998 | Clin Chem1998，44，10： | 1 |
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