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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | External fixation techniques for distal radius fractures显示文摘 | CAPO J T SWAN K G Jr TAN V | 2006 | Clin Orthop Relat Res2006，445，5： | 1 |
| 3 | Geopressure prediction from automati cally-derived seismic velocities 显示文摘 | Kan T K Swan H W | 2001 | Geophysics2001，66，6： | 1 |
| 4 | Late recurrence of dermatofibrosarcoma protuberems in the female breast:a case report显示文摘 | Swan MC Banwell PE Hollwood K | 2005 | Br J Plast Surg2005，58，： | 1 |
| 5 | High-throughput gene mapping in Caenorhabditis elegans 显示文摘 | Swan K A Curtis D E McKusick K B | 2002 | Genome Res2002，7，： | 1 |
| 6 | Limit state analysis of earthen slopes using dual continuum/FEM approaches显示文摘 | SWAN C C SEO Y K | 1999 | International Journal for Numerical and Analytical Methods in Geomechanics1999，23，12： | 1 |
| 7 | Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations 显示文摘 | Swan H Laitinen P Kontula K | 2005 | J Cardiovasc Electrophysiol2005，16，2： | 1 |
| 8 | Resonant Raman spectroscopy of individual metallic and semiconducting single-wall carbon nanotubes under uniaxial strain 显示文摘 | Cronin S B Swan A K Unlu M S | 2005 | Phys Rev B2005，72，03： | 1 |
| 9 | Late recurrence of dermatofibrosarcoma protuberans in the female breast:a case report显示文摘 | Swan MC Banwell PE Hollowood K | 2005 | Br J Plast Surg2005，58，： | 1 |
| 10 | Late recurrence of dermatofibrosarcoma protuberans in the female breast:a case report显示文摘 | Swan MC Banwell PE Hollowood K | 2005 | Br J Plast Surg2005，58，1： | 1 |
| 11 | Review article: the pharmacokinetics of rabeprazole in health and diseases显示文摘 | Swans K Hoyumpa AM Merritt GJ | 1999 | Aliment Pharmacol Ther1999，13，： | 1 |
| 12 | Limit state analysis of earthen slopes using dual continuum/FEM approaches 显示文摘 | SEO Y K SWAN C C | 1999 | International Journal of Numerical Analysis Method in Geotechnical1999，，23： | 1 |
| 13 | Decrease in anogenital distance among male infants with prenatal phthalate exposure显示文摘 | Swan S H Main K M Liu F | 2005 | Environmental Health Perspectives2005，113，8： | 1 |
| 14 | Bringing the Librarian to Online Courses: Cognitive, Social, and Teaching Presence显示文摘 | Weissman N Swan K | 2013 | Advancing Library Education: Technological Innovation and Instructional Design2013，，153： | 1 |
| 15 | Laboratory biology of a uniparental strain of Meteorus pulchricornis (Hymenoptera: Braconidae), an exotic larval parasite of the gypsymoth (Lepidoptera: Lymantriidae) 显示文摘 | Fuester R W Taylor P B Peng H Swan K | 1993 | Annual of the Entomology Society of America1993，86，3： | 1 |
| 16 | Long- term survival following delayed presentation and resec- tion of colorectal liver metastases显示文摘 | Swan PJ Welsh FK Chandrakumaran K | 2011 | Br J Surg2011，98，9： | 1 |
| 17 | Decrease in anogenital distance among male infants with prenatal phthalate exposure显示文摘 | Swan S H Main K M Liu F | | 0，，08： | 1 |
| 18 | Arrhythmic disorder mapped to chromosome 1 q42-q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts显示文摘 | Swan H Piippo K Viitasalo M | 1999 | J Am Coll Cardiol1999，34，： | 1 |
| 19 | Role of robotic surgery in urogyneeologic sur- gery and radical hysterectomy: how far can we go? 显示文摘 | Swan K Advincula AP | 2011 | Curr Opin Urol2011，21，1： | 1 |
| 20 | Role of robotic surgery in urogy- necologic surgery and radical hysterectomy: how far can we go? 显示文摘 | Swan K Advincula AP | 2011 | Curr Opin Urol2011，21，1： | 1 |
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