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您的检索式：作者名="Sweeney VO"
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| 1 | Cyclic strain-induced endothelial MMP-2 :role in vascular smooth muscle cell migration 显示文摘 | Sweeney VO Cummins PM Birney YA | 2004 | Biochem Biophys Res Commun2004，320，2： | 1 |
| 2 | Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella显示文摘Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in pigs.The objectives of this study were to:1)evaluate the anti-S.Typhimurium activity of ANE(containing 46.6%fucoidan,18.6%laminarin,10.7%mannitol,4.6%alginate)in vitro,and;2)compare the effects of dietary supplementation with ANE and Zinc oxide(ZnO)on growth performance,Salmonella shedding and selected gut parameters in naturally infected pigs.This was established post-weaning(newly weaned pig experiment)and following regrouping of post-weaned pigs and experimental re-infection with S.Typhimurium(challenge experiment).Results:In the in vitro assay,increasing ANE concentrations led to a linear reduction in S.Typhimurium counts(P<0.05).In the newly weaned pig experiment(12 replicates/treatment),high ANE supplementation increased gain to feed ratio,similar to ZnO supplementation,and reduced faecal Salmonella counts on d 21 compared to the low ANE and control groups(P<0.05).The challenge experiment included thirty-six pigs from the previous experiment that remained on their original dietary treatments(control and high ANE groups with the latter being renamed to ANE group)apart from the ZnO group which transitioned onto a control diet on d 21(ZnO-residual group).These dietary treatments had no effect on performance,faecal scores,Salmonella shedding or colonic and caecal Salmonella counts(P>0.05).ANE supplementation decreased the Enterobacteriaceae counts compared to the control.Enterobacteriaceae counts were also reduced in the ZnO-residual group compared to the control(P<0.05).ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control(P<0.05).Conclusions:ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,Salmonella shedding,and the expression of inflammatory genes associated with persistent Salmonella infection. | Brigkita Venardou John VO’Doherty Shane Maher Marion TRyan Vivian Gath Rajeev Ravindran Claire Kiely Gaurav Rajauria Marco Garcia-Vaquero Torres Sweeney | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 0 |
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