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| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 5 | Chorioamnionitis and increased neonatal lung lavage fluid matrix metalloproteinase-9 levels: Implications for antenatal origins of chronic lung disease 显示文摘 | Curley AE Sweet DG Thornton CM O'hara MD Chesshyre E Pizzotti J | 2003 | Am J Obstet Gynecol2003，188，4： | 1 |
| 6 | Effect of alkali metal impurities on the low temperature thermal stability of 2090 Al-Cu-Li alloys显示文摘 | Kerr M J Sweet E D Bennett C G | 1996 | Mater Forum1996，21，7222： | 1 |
| 7 | Synovial hemangioma: a report of 20 cases with differential diagnostic considerations 显示文摘 | Devaney K Vinh T N Sweet D E | 1993 | Hum Pathol1993，24，7： | 1 |
| 8 | Three-dimen-sional optical trapping and manipulation of single silvernano wires 显示文摘 | Yan Zijie Jureller J E Sweet J | 2012 | Nano Letters2012，12，10： | 1 |
| 9 | NCT with boron in the treatment of GBM显示文摘 | FARR L E SWEET W H ROBERTSON J S | 1954 | Am J Roentgenol1954，71，： | 1 |
| 10 | Management of obesity and cardiometabolie risk - role of phentermine/extended release topiramate 显示文摘 | Sweeting AN Tabet E Caterson ID | 2014 | Diabetes Metab Syndr Obes2014，12，7： | 1 |
| 11 | Pathological study of eight patients with GBM treated by NCTusing boron 10显示文摘 | GODWIN J T FARR L E SWEET W H | 1955 | Cancer1955，8，： | 1 |
| 12 | Neutron capture therapy with boron in the treatment of glioblastoma multiforme显示文摘 | Farr L E Sweet W H Robertson J S | 1954 | Am J Roentgenol1954，71，： | 1 |
| 13 | The role of matrix metalloproteinases-9 and -2 in development of neonatal chronic lung disease 显示文摘 | Sweet DG Curley AE Chesshyre E | 2004 | Acta Paediatr2004，93，6： | 1 |
| 14 | Kinetics of cyclization of vinyl ehloride-metyl methacrylate copolymes 显示文摘 | SWEET G E BELL J P | 1972 | Polym Sci Polym Chem1972，10，： | 1 |
| 15 | Fat-cell changes as a mechanism of avascular necrosis on the femoralhead in cortisone treated rabbits显示文摘 | Wang G J Sweet D E Regers L | 1997 | J Bone Joint Surg1997，59，6： | 1 |
| 16 | An improved method to recover saliva from human skin: the double swab technique 显示文摘 | Sweet DJ Lorente M Lorente JA Valenzuela A Villanueva E | 1997 | Journal of Forensic Science1997，42，2： | 1 |
| 17 | The early use of continuous positive airway pressure in the treatment of idiopathic respiratory distress syndrone显示文摘 | Kroushop R W Brown E G Sweet A Y | 1995 | J Pediatr1995，87，4： | 1 |
| 18 | Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer 显示文摘 | T'orkelson C J Sweet E Martzcn MR | 2012 | ISRN Oncol2012，2012，25： | 1 |
| 19 | Activation of NF-kappa B by Palmitate in Endothelial Cells A Key Role for NADPH Oxidase-Derived Superoxide in Response to TLR4 Activation显示文摘 | Maloney E Sweet IR Hockenbery DM | 2009 | Arterioscler Thromb Vasc Biol2009，29，9： | 1 |
| 20 | Influence of aphid species and Barley yellow dwarf virus on soft red winter wheat yield显示文摘 | Zwiener C M Conley S P Bailey W C Sweets L E | | 0，，： | 1 |
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