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| 1 | Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii(Harms) J.Leonard stem barks (Caesalpiniaceae) in mice and rats显示文摘Objective: To investigate the toxicity of aqueous extract of Guibourtia tessmannii(Harms) J. Leonard(G. tessmannii) and evaluate its safety.Methods: NMRI mice were used to determine the acute toxicity of G. tessmannii.Increasing concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 days.In order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ weights.Results: LD50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical parameters.Conclusions: The results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake. | Noreen Orianna Koumba Madingou Aristide Traore Alain Souza Marlaine Michelle Boukandou Mounanga Raissa Reine Aworet Samseny Sylvin Ouedraogo Alfred Sababenedyo Traore | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，6： | 2 |
| 2 | The tryptase inhibitor APC-366 reduces the acute airway response to allergen in pigs sensitized to Ascaris suum显示文摘 | Dahlback M Van Der Ploeg I | 2002 | Clin Exp Allergy2002，32，： | 1 |
| 3 | Influence of Water on Rock Discontinuities and Stability of Rock Mass显示文摘 | Sandra Dochez Farid Laouafa Christian Franck Sylvine Guedon Fran?ois Martineau Marion Bost Julie D’Amato | 2013 | Procedia Earth and Planetary Science2013，，： | 1 |
| 4 | Quantitative microbial risk assessment exemplified by Staphylococcus aureus in unripened cheese made from raw milk显示文摘 | LINDQVIST R SYLVIN S VAGSHLM I | 2002 | International Journal of Food Microbiology2002，78，12： | 1 |
| 5 | Effective stress law for the permeability of a limestone显示文摘 | GHABEZLOO S SULEM J SYLVINE (3 | 2009 | International Journal of Rock Mechanics and Mining Sciences2009，46，2： | 1 |
| 6 | Montchamp pallaclium-catalyzed hydro- phosphinylation of alkenes and alkynes显示文摘 | Sylvine Deprele Jean-Luc | 2002 | Journal of the American Chemical Society2002，124，： | 1 |
| 7 | Ras P21 expression in the progression of breast cancer显示文摘 | Frank B Michael V Sylvin C at al | 1987 | Hum Path1987，，： | 1 |
| 8 | Poromechanical behavior of hardened cement paste under isotropic loading显示文摘 | Siavash Ghabezloo Jean Sulem Sylvine Gu e don Frangois Martineau | 2008 | Cement and Concrete Research2008，38，： | 1 |
| 9 | Molecular cloning,expression,and purification of pig interleukin-5显示文摘 | Sylvin H Matvienko O Leochiks A | 2000 | Immunogenetics2000，51，1： | 1 |
| 10 | The effect of a bradykinin B2 receptor antagonist,NPC-567, on allergen-induced airway responses in a porcine model显示文摘 | Sylvin H van der Ploeg 1 Alvlng K | 2001 | Inflamm Res2001，50，9： | 1 |
| 11 | Mechanical support for postcardiotomy cardiogenic shock : Has progress been made 显示文摘 | Sylvin EA Stem DR Goldstein DJ | 2010 | J Card Surg2010，25，4： | 1 |
| 12 | Molecular cloning, expression, and purification of pig interleukin-5 显示文摘 | Sylvin H Matvienko O Leonchiks A | 2000 | Immunogenetics2000，51，1： | 1 |
| 13 | Studies on the internalization mechanism of cationic cell-penetrating peptides显示文摘 | Guillaume D Sylvine C Emmanuelle B | 2003 | J Biol Chem2003，278，31： | 1 |
| 14 | The tryptase inhibitor APC-366 reduces the acute airway response to allergen in pigs sensitized to Ascaris suum显示文摘 | Dahlback M Van-Der-Ploeg I | 2002 | Clin Exp Allergy2002，32，6： | 1 |
| 15 | Ras p21 expression in the progression of breast cancer显示文摘 | Frank B Michael V Sylvin C | 1987 | Hum Path1987，，： | 1 |
| 16 | Ras P21 expression in the progression of breast cancer显示文摘 | Frank B Michael V Sylvin C | 1987 | Hum Pathol1987，18，12： | 1 |
| 17 | Cardiovascular properties of aqueous extract from Mitragyna inermis (wild)显示文摘 | Sylvin Ouédraogo Hantamalala Ralay Ranaivo Mamadou Ndiaye Z.Issaka Kaboré I.Pierre Guissou Bernard Bucher Ramaroson Andriantsitohaina | 2004 | Journal of Ethnopharmacology2004，，2： | 1 |
| 18 | Anthelmintic activity of Saba senegalensis(A.DC.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus显示文摘Objective: To evaluate the anthelmintic property of Saba senegalensis(A.DC) Pichon(Apocynaceae)(S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites treatment.Methods: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/m L was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ruminant.Results: The LC_(50) on adult worms was 6.79 mg/m L and 3.25 mg/m L for the leaves of S. senegalensis and the levamisole(reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/m L of S. senegalensis.Conclusions: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites. | Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin Ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，11： | 0 |
| 19 | Popular Horse Stories and the Invention of the Contemporary Human-Horse Relationship through an Alter Ego Paradigm显示文摘 | Sylvine Piekel Chevalier | 2017 | Journal of Sports Science2017，5，2： | 0 |
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