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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Multidetector CT angiography of pediatric vascular malformations and hemangiomas:utility of 3-D reformatting in differential diagnosis显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，11： | 1 |
| 3 | Multidetector CT angiography of pediatric vascular malformations and hemangiomas: utility of 3-D reformatting in differential diagnosis 显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，： | 1 |
| 4 | Multidetector CT angiography of pediatric vascular malformations and hemangiomas: utility of 3-D reformatting in differential diagnosis显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，： | 1 |
| 5 | Changes in the bacterial microbiota in gut, blood, and lungs following acute LPS instilla- tion into mice lungs显示文摘 | Sze MA Tsuruta M Yang SW | 2014 | PLoS One2014，9，11： | 1 |
| 6 | An explicit material point finite element method for hyper-velocity impact 显示文摘 | ZHANG X SZE K Y MA S | 2006 | International Journal for Numerical Methods in Engineering2006，66，： | 1 |
| 7 | An explicit material point finite element method for hypervelocity impact显示文摘 | ZHANG Xiong SZE K Y MA Shang | 2006 | Int J Numer Methods Eng2006，66，4： | 1 |
| 8 | Factors portending endoleak formation after thoracic aortic stent-graft repair of complicated aortic dissection显示文摘 | Sze DY van den Bosch MA Dake MD | | 0，，： | 1 |
| 9 | Multidetector CT angiography of pediatric vascular malformations and hemangiomas: utility of 3 Dreform atting in differential diagnosis显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | PediatrRadio2005，35，11： | 1 |
| 10 | Factors portending endoleak formation after thoracic aortic stent-graft repair of complicated aortic dissection显示文摘 | Sze DY van den Bosch MA Dake MD | 2009 | Circ Cardiovasc Interv2009，2，2： | 1 |
| 11 | Multidetector CT Angiography of Pediatric Vascular Malformations and Hemangiomas:Utility of 3D Reformatting in Differential Diagnosis显示文摘 | Bittles MA Sidhn MK Sze RW | 2005 | Pediatr Radiol2005，35，11： | 1 |
| 12 | Multidetector CT angiog-raphy of pediatric vascular malformations and hemangiomas:utility of 3-D reformatting in differential diagnosis显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，11： | 1 |
| 13 | 查看详情显示文摘 | X Zhang K Y Sze S Ma | | 0，，： | 1 |
| 14 | An explicit material point finite element method for hyper velocity impact 显示文摘 | Zhang X Sze K Y Ma S | 2006 | International Journal for Numerical Methods in Engineering2006，66，： | 1 |
| 15 | A two-stage algorithm for MIMO blind deconvolution of nonstationary colored signals 显示文摘 | Chor Tin Ma Ding Z Sze Fong Yau | 2000 | IEEE Transaction on Signal Processing2000，48，4： | 1 |
| 16 | Multidetector CT Angiogra phy of Pediatric Vascular Malformations and Hemangiomas:Utility of 3D Reformatting in Differential Diagnosis显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，11： | 1 |
| 17 | The Role of Surfactant in Respiratory Distress Syndrome 显示文摘 | Christopher Cheng-Hwa Ma Sze Ma | 2012 | The Open Respiratory Medi- cine Journal2012，6，： | 1 |
| 18 | Muhidetector CT angiography of pediatric vascular malformation and hemangiomas: utility of 3D reformation in differential diagnosis 显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，11： | 1 |
| 19 | Factors portending endoleak formation after thoracic aortic stent-graft repair of complicated aortic dissection显示文摘 | Sze DY van den Bosch MA Dake MD | 2009 | Circ Cardiovasc Interv2009，2，2： | 1 |
| 20 | Multideteetor CT angiog raphy of pediatric vascular malformations and hemangiomas: utility of 3 - D reformatting in differ ential diagnosis显示文摘 | Bittles MA Sidhu MK Sze RW | 2005 | Pediatr Radiol2005，35，： | 1 |
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