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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Contributory factors to traffic crashes at signalized intersections in Hong Kong显示文摘 | Wong S C Sze N N Li Y C | 2007 | Accident Analysis & Prevention2007，39，6： | 1 |
| 3 | 显示文摘 | Sze Tu L Dehghani F Foster N R | 2002 | Powder Technology2002，126，： | 1 |
| 4 | Diagnostic analysis of the logistic model for pedestrian injury severity in traffic crashes显示文摘 | Sze N N Wong S C | 2007 | Accident Analysis and Prevention2007，39，6： | 1 |
| 5 | Computed tomogra-phy-guided percutaneous needle biopsy of pulmonary nodules :impact of nodule size on diagnostic accuracy 显示文摘 | Kothary N Lock L Sze DY | 2009 | Clin LungCancer2009，，10： | 1 |
| 6 | The roles of exposure and speed in road safety analysis 显示文摘 | PEI Xin WONG S C SZE N N | 2012 | Accident Analysis and Prevention2012，48，： | 1 |
| 7 | The chlorine budget of the present atmosphere:a modeling study显示文摘 | Winsenstein D K KO M K W Sze N | 1992 | Journal of Geophysical Research1992，97，： | 1 |
| 8 | Incidence of recurrent cystocele after anterior colporrhaphy with and without concomitant transvaginal needle suspension显示文摘 | Kohli N Sze EH Roat TW | 1996 | Am J Obstet Gynecol1996，175，6： | 1 |
| 9 | Linear preservers of tensor product of unitary orbits and product numerical range显示文摘 | Li C K Poon Y T Sze N S | 2013 | Linear Algebra Appl2013，，438： | 1 |
| 10 | Polygonal finite element method for nonlinear constitutive modeling of polycrystalline ferroelectrics 显示文摘 | Sze K Y Sheng N | 2005 | Finite Elements in Analysis and Design2005，42，： | 1 |
| 11 | chordomas:MR imaging显示文摘 | Sze G Uichanco LS 3rd BrantZawadzki M N | 1988 | Radiology1988，166，11： | 1 |
| 12 | Freon consumption: implications for atmospheric ozone显示文摘 | WOFSY S C MCELROYP M B SZE N D | 1975 | Science1975，187，4176： | 1 |
| 13 | Is a combined enforcement and penalty strategy effective in comba ting red light violations? An aggregate model of vio- lation behavior in Hong Kong显示文摘 | Sze N N Wong S C Pei X | 2011 | Accident Analy- sis & Prevention2011，43，1： | 1 |
| 14 | Hypophysitis: endocrinologic and dynamic MR findings显示文摘 | Sato N Sze G Endo K | 1998 | AJNR Am J Neuroradiol1998，19，3： | 1 |
| 15 | Extradural spinal meningoma: MR/显示文摘 | Sato N Sze G | 1997 | Neuroradiology1997，39，6： | 1 |
| 16 | Role of heterogene- ous conversion of N2O8 on sulphate aerosols in global ozone losses显示文摘 | Rodriguez J M Malcolm K W K Sze N D | 1991 | Nature1991，352，： | 1 |
| 17 | Computed tomographyguided percutaneous needle biopsy of pulmonary nodules:impact of nodule size on diagnostic accuracy显示文摘 | Kothary N Lock L Sze DY | | 0，，： | 1 |
| 18 | Raman Spectroscopy of Carbon-containing Particles显示文摘 | Escribano R Sloan J J Siddique N Sze N Dudev T | 2001 | Vibrational Spectroscopy2001，26，2： | 1 |
| 19 | Ramanspectroscopic characterization of carbonaceous aerosols显示文摘 | SZE S K SIDDIQUE N SLOAN J J ESCRIBANO R | 2001 | Atmospheric Environment2001，35，3： | 1 |
| 20 | Cystic pituitary mass in neurosarcoidosis显示文摘 | Sato N Sze G Kim JH | 1997 | AJNR1997，18，6： | 1 |
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