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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Determination of trace elements in human liver biopsy samples by ICP–MS and TXRF: hepatic steatosis and nickel accumulation显示文摘 | Imre Varga ágnes Szebeni Norbert Szoboszlai Béla Kovács | 2005 | Analytical and Bioanalytical Chemistry2005，，3： | 1 |
| 3 | The nucleolus: an old fac- tory with unexpected capabilities显示文摘 | Olson MOJ Dundr M Szebeni A | 2000 | Trends in Cell Biology2000，10，5： | 1 |
| 4 | Formation of complemen-t activating particles in aqueous solutions of Taxol:poss-ible role in hypersensitivity reactions显示文摘 | SZEBENI J ALVING C R SAVAV S | 2001 | Int Immunopharmacol2001，1，4： | 1 |
| 5 | Complement activation-related pseudollergy: a new class of drug-induced acute immune toxicity 显示文摘 | Szebeni J | 2005 | Toxicology2005，216，23： | 1 |
| 6 | Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity 显示文摘 | Szebeni J | 2005 | Toxicol2005，216，23： | 1 |
| 7 | Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease 显示文摘 | SZEBENI B VERES G DEZSOFI A | 2008 | Clin Exp Immunol2008，151，1： | 1 |
| 8 | Complement activation by cremophor EL as a possible contributor to hypersensitivity to paclitaxel:an in vitro study显示文摘 | Szebeni J Muggia FM Alving CR | 1998 | J Natl Cancer Ins1998，90，4： | 1 |
| 9 | Complement Activation by Cremophor EL as a Possible Contributor to Hypersensitivity to Paclitaxel: An in Vitro Study 显示文摘 | Szebeni J Muggia FM Alving CR | 1998 | Journal of The National Cancer Institute1998，90，4： | 1 |
| 10 | Complement activation by Ctemophor EL as a possible contributor to hypersensitivity to Paclilaxel:an in vitro study显示文摘 | SZEBENI J MUGGIA F M AI VING C R | 1998 | J Natl Cancer Inst1998，90，4： | 1 |
| 11 | Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study 显示文摘 | Szebeni J Muggia FM Alving CR | 1998 | J Natl Cancer Inst1998，90，4： | 1 |
| 12 | Gene expression analy-ses of neurons,astrocytes,and oligodendrocytes isolated by laser cap-ture microdissection from human brain:detrimental effects of labora-tory humidity显示文摘 | Ordway GA Szebeni A Duffourc MM | 2009 | Journal of neuroscience research2009，87，11： | 1 |
| 13 | Complement activation-related pseudoallergy: A new class of drug-induced acute immune toxicity 显示文摘 | Szebeni J | 2005 | Toxicology2005，216，23： | 1 |
| 14 | Complement activation-related pseudoallergy:a new class of drug-induced acute immune toxicity显示文摘 | Szebeni Janos | 2005 | Toxicology2005，216，23： | 1 |
| 15 | Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents 显示文摘 | Szebeni J | 2001 | Crit Rev Ther Drug Carr Syst2001，，18： | 1 |
| 16 | The role of complement activation in hypersensitivity to pegylated liposomal doxorybicin (Doxil) 显示文摘 | Szebeni J Baranyi L Savay S | 2000 | Liposome Res2000，，10： | 1 |
| 17 | Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel:An in vitro study显示文摘 | Szebeni J Muggia FM Alving CR | 1998 | J Natl Cancer Inst1998，90，4： | 1 |
| 18 | Formation of complement- activating particles in aqtteous solutions of Taxol: possible role in hypersensitivity reactions显示文摘 | Szebeni J Alving CR Savay S | 2001 | Int J Immunopharmacol2001，，1： | 1 |
| 19 | Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel:an in vitro study显示文摘 | Szebeni J Muggia FM Alving CR | 1998 | J Natl Cancer Inst1998，90，4： | 1 |
| 20 | Complement activation following first exposure to pegylated liposomal doxorubicin(Dexil):possible role in hypersensitivity reaction显示文摘 | Chanan-Khan A Szebeni J Savay S | 2003 | Annals of Oncology2003，，14： | 1 |
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