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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Pulmonary function in patients with diabetes mellitus显示文摘 | Carlos A Benbassa T Stern E | 2001 | Am J Med Sci2001，322，3： | 1 |
| 3 | Readiness to report medical treatment errors: the effects of safety procedures, safety informa- tion, and priority of safety 显示文摘 | Naveh E Katz - Navon T Stern Z | 2006 | Med Care2006，44，： | 1 |
| 4 | Rapid detection of the F508 detection in Cystic Fibrosis by allele specific PCR and electrochemiluminescent detection 显示文摘 | STERN H J CARLOS R D SCHUTZBANK T E | 1995 | Clinical Biochemistry1995，28，： | 1 |
| 5 | Administration of olanzapine to prevent postoperativ delirium in elderly joint replacement patients:a randomized,controlled trial显示文摘 | Larsen K A Kelly S E Stern T A | | 0，，05： | 1 |
| 6 | Nanotechnology safety concerns revisited显示文摘 | Stern S T McNeil S E | 2008 | Toxicological Sciences2008，101，1： | 1 |
| 7 | The Influ- ence of Situational Learning Orientation, Autonomy, and Voice on Error Making: The Case of Resident Physicians 显示文摘 | STERN Z KATZ-NAVON T NAVEH E | 2008 | Management Science2008，54，9： | 1 |
| 8 | Protection cycles in mesh WDM networks显示文摘 | Ellinas G Hailemariam A G Stern T E | 2000 | IEEE Journal on Selected Areas in Communications2000，18，10： | 1 |
| 9 | The struggle to govern the commons 显示文摘 | Dietz T Ostrom E Stern P C | 2003 | Science2003，302，： | 1 |
| 10 | 查看详情显示文摘 | Woo J H Treu T Barth A J Wright S A Walsh J L Bentz M C Martini P Bennert A N Canalizo G Filippenko A V Gates E Greene J Malkan M A Stern D Minezaki T | | 0，，： | 1 |
| 11 | Analysis of the transcription factor WUSCHEL and its functional homologue in Antirrhinum reveals a potential mechanism for their roles in meristem maintenance显示文摘 | Kieffer M Stern Y Cook H Clerici E Maulbetsch C Laux T Davies B | | 0，，： | 1 |
| 12 | Structure of cathodically deposited nickel hexacyanoferrate thin films using XRD and EXAFS显示文摘 | STEEN W A HAN S YU Q GORDON R A CROSS J O STERN E A SEIDLER G T JEERAGE K M SCHWARTZ D T | 2002 | Langmuir2002，18，： | 1 |
| 13 | Protection cycles in mesh WDM netoworks显示文摘 | Ellinas G Hailemeariam A G Stern T E | 2000 | IEEE Journal on Selected Areas in Communications2000，18，10： | 1 |
| 14 | Modern and historical fluxes of halogenated organic contaminants to a lake in the Canadian arctic, as determined from annually laminated sediment cores显示文摘 | Stern G A Braekevelt T E Helm P A | 2005 | Sci Total Environ2005，342，： | 1 |
| 15 | Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach 显示文摘 | Stern A Doron-Faigenboim A Erez E Martz E Bacharach E Pupko T | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 16 | Usefulness of the double-wall sign in detecting pneumothorax in patients with giant bullous emphysema显示文摘 | Waitches G M Stern E J Dubinsky T J | 2000 | AJR Am J Roentgenol2000，174，6： | 1 |
| 17 | Protection cycles in mesh WDM networks显示文摘 | A G HAILEMARIAM T E STERN | 2000 | IEEE Journal on selected areas in communications Oct2000，18，10： | 1 |
| 18 | The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘 | Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R | 2007 | Science2007，318，5848： | 1 |
| 19 | Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk 显示文摘 | Aronson K Biller A Woolcott C Sterns E McCready D Lickley L Fish E Hiraki G Holloway C Ross T | 2000 | Cancer Epidemiol Biomarkers Prev2000，9，63： | 1 |
| 20 | The Struggle to Govern the Commons 显示文摘 | Dietz T Ostrom E Stern P | 2003 | Science2003，302，5652： | 1 |
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