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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | 黄土峁坡农地侵蚀与坡长的关系显示文摘采用^(137)Cs法测定土壤侵蚀量和细沟量测的综合研究表明,黄土峁坡的长坡农地,在细沟最大深度未抵达犁底层的坡长范围内,侵蚀速率与坡长呈正相关,大于此坡长后不呈正相关.犁耕层和犁底层组成的双层土壤结构,控制了峁坡农地的细沟发育,决定了侵蚀速率与坡长的关系.径流小区的坡面径流汇聚和细沟发育情况往往与实际峁坡农地差异较大,依据径流小区观测资料统计得出的峁坡农地的侵蚀速率与坡长呈正相关的结论,不适用于长坡农地. | 张信宝 文安邦 奎因TA 沃林DE | 1998 | 中国水土保持1998，，1： | 11 |
| 3 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 4 | 眼前节内眼手术应用5%吡咯烷酮碘两种不同用法的前瞻性随机化比较研究显示文摘目的:确定5%吡咯烷酮碘采用两种不同的方法(结膜囊滴两滴和10ml溶液穹窿结膜冲洗)对降低结膜囊菌群的功效。方法:在这项前瞻性对照实验中。将行眼前节手术的200只眼随机分为对照组和研究组。两组病例术前均给予氧氟沙星滴眼液局部点眼和5%吡咯烷酮碘眶周区域皮肤擦洗消毒。术前对照组眼结膜囊内给予2滴5%吡咯烷酮碘溶液,研究组眼用5%吡咯烷酮碘溶液冲洗穹窿结膜。分别于术前和术后4个时间点行结膜细菌培养。结果:研究组78只眼中20只眼(26%)术前结膜细菌培养阳性:对照组94只眼中40只眼(43%)为阳性(P=0.02)。手术结束时。研究组78只眼中14只眼(18%)、对照组94只眼中30只眼(32%)结膜细菌培养阳性(PP=0.05)。结论:手术时应用5%吡咯烷酮碘溶液冲洗穹窿结膜与结膜囊仅点入两滴相比。前者显著降低了结膜细菌培养阳性率。 | Herminia Mino de Kaspar Robert T. Chang Kuldev Singh Peter R. Egbert Mark S. Blumenkranz Christopher N. Ta 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 6 |
| 5 | Detection of long bones based on Barker code excited ultrasonic guided waves显示文摘Single pulse excited ultrasonic guided wave surfers high attenuation during the propagation in long bones.This results in small amplitude and low signal-to-noise ratio(SNR)of measured signals.Thus,the Barker code excitation is introduced into long bone detection to improve the quality of received signals,due to its efficiency in increasing amplitude and SNR.Both simulation and in vitro experiment were performed,and the results were decoded by the weighted match filter(WMF) and the finite impulse response- least squares inverse filter(FIRLSIF),respectively.The comparison between the results of Barker code excitation and sine pulse excitation was presented.For 13-bit Barker code excitation,WMF produced 13 times larger amplitude than sine pulse excitation,while FIR-LSIF achieved higher peak-sidelobe-level(PSL) of —63.59 dB and better performance in noise suppression.The results show that the Barker code excited guided waves have the potential to be applied to the long bone detection. | ZHANG Huilin SONG Xiaojun TA De'an | 2014 | Chinese Journal of Acoustics2014，33，2： | 5 |
| 6 | Reflection and transmission characteristics of ultrasonic guided waves in fractured long bone显示文摘对用超声的指导波浪(GW ) 的折断的长骨头的评价获得了可观的注意。这份报纸集中于使用混合边界元素方法(HBEM ) 在折断的长 bones.The 思考系数(RC ) 和传播系数(TC ) 分析超声的 GW 的繁殖特征因为不同 depth-to-width 比率(d/w ) 裂缝数字地计算、分析。主要产量模式,包括传播和思考模式,与发生模式一样,这被显示出。为一些裂缝,不同 TC 曲线总是在邻近的频率得到了本地最大值。为不同 d/w 裂缝,大多数 TC 曲线有没被重叠的本地最大值。这些模拟结果是有用的为评估骨头质量并且在长外皮的骨头提供裂缝的数字结果的份量上优化发生 GW 的模式和频率。 | XU Kailiang TA De'an WANG Weiqi | 2010 | Chinese Journal of Acoustics2010，29，3： | 3 |
| 7 | Effect of trabecular bone material properties on ultrasonic backscattering signals显示文摘In this study,ultrasonic backscattering signals in cancellous bones were obtained by finite difierence time domain(FDTD)simulations,and the effect of trabecular material properties on these signals was analyzed.The backscatter coefficient(BSC)and integrated backscatter coefficient(IBC)were numerically investigated for varying trabecular bone material properties,including density,Lame coefficients,viscosities,and resistance coefficients.The results show that the BSC is a complex function of trabecular bone density.and the IBC increases as density increases.The BSC and IBC increase with the first and second Lamd coefficients.While not very sensitive to the second viscosity of the trabeculae.the BSC and IBC decrease as the first viscosity and resistance coefficients increase.The results demonstrate that,in addition to bone mineral density(BMD)and microarchitecture,trabecular material properties significantly influence ultrasonic backscattering signals in cancellous bones.This research furthers the understanding of ultrasonic backscattering in cancellous bones and the characterization of cancellous bone status. | LIU Chengcheng TA De'an WANG Weiqi | 2014 | Chinese Journal of Acoustics2014，33，1： | 2 |
| 8 | The spectrum entropy estimation method for ultrasonic backscattering signal in cancellous bones显示文摘In the application of cancellous bone ultrasound diagnosis based on backscattering method,it is of great importance to estimate fast and accurately whether the valid backscattering signal exists in the received signal.We propose a fast estimation method based on spectrum entropy method.With 984 records of adult calcaneus clinical data,we estimate the validity of the backscatter signal using this method.The results of the proposed method and the results of experience-base judgement were compared and analyzed.And two key parameters,the signal range length and the segment number of the spectrum entropy,were analyzed.The results show when the signal range length is 13 us and the segment number is 15-20,this method can get the best result(accuracy>95%,sensitivity>99%,specificity>87%),while taking little calculation time(1.5 ms).Therefore,this spectrum entropy method can satisfy the accuracy and real-time requirements in the ultrasonic estimation for cancellous bone. | XU Feng XU Yiwen LIU Chengcheng TA De'an GUO Jianzhong | 2017 | Chinese Journal of Acoustics2017，36，3： | 2 |
| 9 | Study on the mean trabecular bone spacing based on fundamental frequency estimation method显示文摘从 cancellous 骨头的超声的反散射信号能被用来由于它提供骨头微观结构的信息的能力有效地诊断骨质疏松症。吝啬的 trabecular 骨头间距 MTBS 是为骨头微观结构的 characteriza- tion 的重要参数之一。这份报纸建议了基于基本频率评价估计方法的 MTBS,它从模拟被用于反散射信号,并且在 vitro 牛的 trabeculae。估计的 MTBS 与简化反的过滤器追踪的那些相比筛算法和 autoregressive AR cepstrum 方法。结果证明建议方法面对小 signal-to-noise 比率 SNR,和到常规的弥漫的 scatterers 的大散布力量比率为有更精确的估计和更小的估计的变化的 MTBS 评价是很柔韧的。 | YANG Baiding TA De'an WANG Weiqi | 2011 | Chinese Journal of Acoustics2011，30，3： | 2 |
| 10 | The metabolic syn- drome and cardiovascular disease mortality in middle-aged men 显示文摘 | Lakka HM laaksonen DE Lakka TA | 2002 | JAMA2002，228，21： | 1 |
| 11 | The metabolic syndrome and total and cardiovascular disease mortality in middle aged men显示文摘 | Lakka HM laaksonen DE Lakka TA | 2002 | JAMA2002，288，： | 1 |
| 12 | Efficacy and safety of nesirtide in patients with acute decompensated heart failure显示文摘 | De Wald TA Hernandez AF | 2010 | Expert Rev Cardiovasc Ther2010，8，2： | 1 |
| 13 | Retinopathy is reduced during experimental di- abetes in a mouse model of outer retinal degeneration 显示文摘 | de Gooyer TE Stevenson KA Htmlphries P Simpson DA Gardi- ner TA Stitt AW | 2006 | In- vest Ophthalmol Vis Sci2006，47，12： | 1 |
| 14 | Physical activity in prevention and treatment of the metabolic syndrome 显示文摘 | Lakka TA Laaksonen DE | 2007 | Appl Physiol Nutr Metab2007，32，1： | 1 |
| 15 | Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy 显示文摘 | Gardiner TA Gibson DS de Gooyer TE | 2005 | Am J Pat hoi2005，166，： | 1 |
| 16 | Pulmonary radiofrequency ablation:long-term safety and efficacy in 153 patients显示文摘 | Simon CJ Dupuy DE Dipetrillo TA | | 0，，： | 1 |
| 17 | Combining tar?geted therapeutics in the era of precision medicine显示文摘 | Papadatos-Pastos D De Miguel Luken MJ Yap TA | 2015 | BrJ Cancer2015，112，1： | 1 |
| 18 | Predictors for overactive bladder symptoms after pelvic organ prolapse surgery显示文摘 | de Boer TA Vierhout ME | 2011 | Curr Opin Obstet Gynecol2011，23，： | 1 |
| 19 | Personalization of prostate cancer pre- vention and therapy:are clinically qualified biomarkers in the horizon显示文摘 | Yap TA Swantan C de Bono JS | 2012 | EPMA J2012，3，1： | 1 |
| 20 | The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11 显示文摘 | Bell TA de la Casa-Esperon E Doherty HE | 2006 | Genetics2006，172，1： | 1 |
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