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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | Plasmonics for solid-state lighting: enhanced excitation and directional emission of highly efficient light sources显示文摘Light sources based on reliable and energy-efficient light-emitting diodes (LEDs) are instrumental in the development of solid-statelighting (SSL). Most research efforts in SSL have focused on improving both the intrinsic quantum efficiency (QE) and the stability oflight emitters. For this reason, it is broadly accepted that with the advent of highly efficient (QE close to 1) and stable emitters, thefundamental research phase of SSL is coming to an end. In this study, we demonstrate a very large improvement in SSL emission (above70-fold directional enhancement for p-polarized emission and 60-fold enhancement for unpolarized emission) using nanophotonicstructures. This is attained by coupling emitters with very high QE to collective plasmonic resonances in periodic arrays of aluminumnanoantennas. Our results open a new path for fundamental and applied research in SSL in which plasmonic nanostructures are able tomold the spectral and angular distribution of the emission with unprecedented precision. | Gabriel Lozano Davy J Louwers Said RK Rodrı´guez Shunsuke Murai Olaf TA Jansen Marc A Verschuuren Jaime Gomez Rivas | 2013 | Light(Science & Applications)2013，2，1： | 8 |
| 3 | 三级高血压单位5100例患者低血钾症与原发性醛固酮增多症的发病率显示文摘常伴有低血钾症的原发性醛固酮增多症(原醛)被认为是一个少见病。广泛筛查高血压患者发现正常血钾的原醛发生率增加。许多研究报道原醛低血钾症的发生率,相反,低血钾症患者中原醛的发生率并不明确。在该回顾性观察研究,研究者探讨了高血压患者中低钾的发生率以及低血钾症合并高血压患者中原醛的发生率。 | 赵狄(译) 刘莉(审校) Burrello J Monticone S Losano I Cavaglià G Buffolo F Tetti M Covella M Rabbia F Veglio F Pasini B Williams TA Mulatero P | 2020 | 中华高血压杂志2020，28，3： | 7 |
| 4 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 5 | Acute mesenteric ischemia: value of computerized tomography diagnosis显示文摘 | Huisman TA Benoit CH Traber J | 2000 | Schweiz Rundsch Med Prax2000，89，23： | 2 |
| 6 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 7 | CagA status of Helicobacter pylori infection and p53 gene mutations in gastric adenocarcinoma显示文摘 | Shibata A Parsonnet J Longacre TA | 2002 | Carcinogenesis2002，23，3： | 2 |
| 8 | Reliability of selective pulmonary artefiography in the diagnosis of pulmonary embolism 显示文摘 | Quinn MF LundeU C J Klotz TA | 1987 | AJR Am J Roentgenol1987，149，3： | 1 |
| 9 | The significance of natural and synthetic auxins in the control of stomatal movements 显示文摘 | Cox R C Snaith P J Mansfield TA | 1985 | Acta Horticulture1985，171，： | 1 |
| 10 | Anterior instrumentation in the managerment of thoracolumbar burst fractures 显示文摘 | Ghanayem A J Zdeblick TA | 1997 | Clin Orthop1997，，335： | 1 |
| 11 | Oxidative stress and neutrophil activation-the two keystones of ischemia/ reperfusion injury显示文摘 | Kaminski KA Bondu TA Korechi J | 2002 | IntJcardiol2002，86，1： | 1 |
| 12 | Survival following hepatic resection of colorectal cancer metastases: a national experience 显示文摘 | Robertson D J Stukel TA Gottlieb D J | 2009 | Cancer2009，115，4： | 1 |
| 13 | Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations 显示文摘 | Bhowmik A Seemungal TA Sapsford R J | 2000 | Thorax2000，55，2： | 1 |
| 14 | Evolution of pulmonary surfactants for the treatment of neonatal respiratory distress syndrome and paediatric lung diseases显示文摘 | Mazela J Merritt TA Gadzinowski J | 2006 | Acta Paediatr2006，95，9： | 1 |
| 15 | Her-2/neu in breast cancer: interobserver variability and performance of immunohlstochemistry with 4 antibodies compared with fluorescent in situ hybridization显示文摘 | THOMSON TA HAYES MM SPINELLI J J | 2001 | Mod Pathol2001，14，11： | 1 |
| 16 | MDCT of patieats with acute abdominal pain a new perspective using coronal reforma- tions from submillimeter isotropic voxels显示文摘 | Paulson EK Jaffe TA Thomas J | 2004 | AJR Am J Roent genol2004，183，： | 1 |
| 17 | Impact of al?pha-blockers in men with spinal cord injury and upper tract sta?sis 显示文摘 | Linsenmeyer TA Horton J Benevento J | 2002 | J Spinal Cord Med2002，25，： | 1 |
| 18 | Oxida-tive stress and neutrophil activation-the two key-stones of ischemia/reperfusion injury显示文摘 | Kaminski KA Bonda TA Korecki J | 2002 | Int J Car-diol2002，86，1： | 1 |
| 19 | Osteogenesis imperfecta type II: fetal magnetic resonance imaging findings显示文摘 | Solopova A Wisser J Huisman TA | 2008 | Fetal Diagn Ther2008，24，4： | 1 |
| 20 | Hypertension and cognitive function:pathophysiologic effects of hypertension on the brain显示文摘 | Manolio TA Olson J Longstreth WT | 2003 | Curr Hypertens Rep2003，5，3： | 1 |
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