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| 1 | Magnetic properties of perpendicularly orientated L1_0 FePt nanoparticles显示文摘L10 FePt films were deposited on MgO (001) substrates heated to 700°C by magnetron sputtering.Assisted by the misfit of lattice between film and substrate,strong (001) texture was formed.The film at nominal thickness t N=5 nm was composed of nanoparticles with a size of~70 nm,and showed a high coercivity of~105 kOe at 4.2 K.At t N=~50 nm,as the film changed from discontinuous to continuous,the coercivity dropped about one order of magnitude.Micromagnetic simulation implies that the magnetization reversal is a vortex-like nuclear type.The ideal coercivity of a separated single-domain L10 FePt nanoparticle with a size of 70 nm×70 nm×5 nm is~121 kOe.This tells us that the experimental coercivity has nearly reached the limit of ideal single crystalline nanoparticles. | MO XiaoJing XIANG Hui LI GuoQing CHEN Peng XIONG ZuHong WANG JunZhong ISHIO ShunJi SMTO Hitoshi SHIMA ToshiYuki TAKANASHI KoKi | 2010 | Chinese Science Bulletin2010，55，8： | 3 |
| 2 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 3 | Differences in the time course of splenial and white matter lesions in clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS)显示文摘 | Jun-ichi Takanashi Atsushi Imamura Fumio Hayakawa Hitoshi Terada | 2010 | Journal of the Neurological Sciences2010，，1： | 2 |
| 4 | Spatial and temporal variation in soil respiration in a Southeast Asian tropical rainforest显示文摘 | Yoshiko Kosugi Tomonori Mitani Masayuki Itoh Shoji Noguchi Makoto Tani Naoko Matsuo Satoru Takanashi Shinjiro Ohkubo Abdul Rahim Nik | 2007 | Agricultural and Forest Meteorology2007，，1： | 2 |
| 5 | Analyses of the factors influencing bone graft infection after delayed cranioplasty显示文摘 | A. Matsuno H. Tanaka H. Iwamuro S. Takanashi S. Miyawaki M. Nakashima H. Nakaguchi T. Nagashima | 2006 | Acta Neurochirurgica2006，，5： | 2 |
| 6 | Vascular endothelial growth factor level as a prognostic determinant of small cell lung cancer in Janpanese patients 显示文摘 | Hasegawa Y Takanashi S Okudera K | 2005 | lntern Med2005，44，1： | 1 |
| 7 | Enhanced magnetoresistance in insulating granular systems : evidence for higher-order tunneling显示文摘 | MITANI S TAKAHASHI S TAKANASHI K | 1998 | Phys Rev Lett1998，81，13： | 1 |
| 8 | Systemically injected exo- somes targeted to EGFR deliver antitumor microRNA to breast cancer cells显示文摘 | Ohno SI Takanashi M Sudo K | 2013 | Mol Ther2013，21，1： | 1 |
| 9 | Acase of transfusion associated graft versus host disease not prevented by white cell reduction filters 显示文摘 | Akahoshi M Takanashi M Masuda M | 1992 | Transfusion1992，32，1： | 1 |
| 10 | Mucinous Cystic Tumors of the Pancreas显示文摘 | Takashi Hara Hideaki Kawashima Masahiro Ishigooka Motoya Kashiyama Setsuji Takanashi Sayuki Yamazaki Yoshio Hosokawa | 2002 | Surgery Today2002，，11： | 1 |
| 11 | Weekly paclitaxel and nedaplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer: a phase Ⅰ/Ⅱ study显示文摘 | HASEGAWA Y TAKANASHI S OKUDERA K | 2004 | Jpn J Clin Oncol2004，34，11： | 1 |
| 12 | Proton magnetic resonance spectroscopy of patients with parkinsonism显示文摘 | Abe K Terakawa H Takanashi M | 2000 | Brain Res Bull2000，52，6： | 1 |
| 13 | Nomadic Computing Environment Employing Wired and Wireless Networks显示文摘 | Morikura M Takanashi H | 1998 | IEICE Trans Commun1998，81，8： | 1 |
| 14 | Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes 显示文摘 | Ishida T Takanashi Y Doi H | 2002 | Int J Pharm2002，232，12： | 1 |
| 15 | Analysis of Carboxyl Group in Coal and Coal Aromaticity by Fourier Trans- form Infrared (FTIR) Spectrometry显示文摘 | Geng Wenhua Nakajima T Takanashi H | 2009 | Fuel2009，88，1： | 1 |
| 16 | Wide range of CNS manifestations of rotavirus infection 显示文摘 | Takanashi J | 2011 | BrainDev2011，33，1： | 1 |
| 17 | Sisters with clinically mild encephalopathy with a reversible splenial lesion (MERS)-like features;familial MERS? 显示文摘 | Imamura T Takanashi J Yasugi J | 2010 | J Neurol Sci2010，290，1： | 1 |
| 18 | Kawasaki diseasecomplicated by mild encephalopathy with a reversible splenial lesion(MERS)显示文摘 | Takanashi J Shirai K Sugawara Y | 2012 | J NeurolSci2012，315，12： | 1 |
| 19 | Sisters with clinically mild encephalopathy with a reversible splenial lesion (MERS)-like features: Familial MERS显示文摘 | Takanashi J Yasugi J | 2010 | J Neurol Sci2010，290，12： | 1 |
| 20 | Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow derived neuronal cells显示文摘 | Kawada H Takizawa S Takanashi T | 2006 | Circulation2006，113，： | 1 |
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