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| 1 | Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease显示文摘A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD. | Chang Kong Hao Xie Zhenxing Gao Ming Shao Huan Li Run Shi Lili Cai Shanshan Gao Taolei Sun Chaoyang Li | 2019 | Virologica Sinica2019，34，5： | 4 |
| 2 | Chiral polymer-based biointerface materials显示文摘Chirality is a unique phenomenon in nature. Chiral interactions play an important role in biological and physiological processes, which provides much inspiration for scientists to develop chiral materials. As a breakthrough from traditional materials, biointerface materials based on chiral polymers have attracted increasing interest over the past few years. Such materials elegantly combine the advantages of chiral surfaces and traditional polymers, and provide a novel solution not only for the investigation of chiral interaction mechanisms but also for the design of biomaterials with diverse applications, such as in tissue engineering and biocompatible materials, bioregulation, chiral separation and chiral sensors. Herein, we summarize recent advances in the study of chiral effects and applications of chiral polymer-based biointerface materials, and also present some challenges and perspectives. | LI MinMin QING GuangYan ZHANG MingXi SUN TaoLei | 2014 | Science China Chemistry2014，57，4： | 2 |
| 3 | New approach for chiral separation: from polysaccharide-based materials to chirality-responsive polymers显示文摘Chiral separation that is closely related to daily life is a meaningful research. Polysaccharide-(e.g., cellulose, amylose derivatives) based chiral packing materials afford powerful chiral stationary phases(CSPs) toward a broad range of racemic compounds. However, considering the explosive growth of specific chiral drugs, the separation efficiencies of these CSPs need further improvement, which calls for new approaches and strategies. Smart polymers can change their physical or chemical properties dynamically and reversibly according to the external stimuli(e.g., thermo-, pH, solvent, ion, light, critical parameters for chromatographic separation) exerted on them, subsequently resulting in tunable changes in the macroscopic properties of materials. In addition to their excellent controllability, the introduction of chiral characteristics into the backbones or side-chains of smart polymers provides a promising route to realize reversibly conformational transition in response to the chiral analytes. This dramatic transition may significantly improve the performance of materials in chiral separation through modulating the enantioselective interactions between materials and analytes. With the help of chirality-responsive polymers, intelligent and switchable CSPs could be developed and applied in column-liquid chromatography. In these systems, the elution order or enantioselectivity of chiral drugs can be precisely modulated, which will help to solve many challenging problems that involve complicated enantiomers. In this paper we introduce some typical examples of smart polymers that serve as the basis for a discussion of emerging developments of CPSs, and then briefly outline the recent CSPs based on natural and certain synthetic polymers. | DING Peng CHANG BaiSong QING GuangYan SUN TaoLei | 2014 | Science China Chemistry2014，57，11： | 2 |
| 4 | Interfacial materials with special wettability显示文摘 | Wong Tak-Sing Sun Taolei Feng Lin | | 0，，： | 1 |
| 5 | A study of interracial dilational properties of two different structure demulsifiers at oil-water interfaces显示文摘 | WANG Yiyang ZHANG Lu SUN Taolei | 2004 | J of Colloid and Interface Science2004，270，： | 1 |
| 6 | Bioinspired surfaces with special wettability显示文摘 | SUN Taolei FENG Lin JIANG Lei | 2005 | Accounts of Chemical Research2005，38，8： | 1 |
| 7 | Reversible Switching between Superhydrophilicity and Superhydrophobicity显示文摘 | Sun Taolei Wang Guojie Feng Lin | 2004 | Angew Chem Int Ed2004，43，3： | 1 |
| 8 | 显示文摘 | Sun Taolei Feng Lin Gao Xuefeng | 2005 | Accounts of Chemical Research2005，38，8： | 1 |
| 9 | Reversal switching between superhydrophilicity and superhydrophobicity显示文摘 | Sun Taolei Wang Guojie Feng Lin | 2004 | Angew Chem Int Ed2004，，43： | 1 |
| 10 | Influence of demulsifies of different structures on interfaci',d dilatational properties of an oil-water interface containing surface-active fractions from crude oil 显示文摘 | Sun Taolei Zhang Lu Wang Yiyang | 2002 | J Colloid Interface Sei2002，255，1： | 1 |
| 11 | Influence of demulsifiers of different structures on interfacial dilational properties of an oil water interface containing surface active fractions from crude oil显示文摘 | Sun Taolei Zhang Lu Wang Yiyang | | 0，，： | 1 |
| 12 | Preparation and electrochemical characterization of slngle-crystalline spherical LiNi1/3 Co1/3 Mnv30z pow- ders cathode material for Li-ion batteries显示文摘 | Xiaoyan Hail Qingfei Meng Taolei Sun | 2010 | J Power Sources2010，19，： | 1 |
| 13 | Bioinspired surfaces with special wettability显示文摘 | Sun Taolei Feng Lin Gao Xuefeng | 2005 | Acc Chem Res2005，38，： | 1 |
| 14 | Influence of Demulsifiers of Different Structures on Interfacial Dilational Properties of an Oil-Water Interface Containing Surface-Active Fractions from Crude Oil显示文摘 | Sun Taolei Zhang Lu Wang Yiyang etc | 2002 | Journal of Colloid and InterfaceScience2002，255，： | 1 |
| 15 | No platelet can adhere-largely improved blood compatibility on nanostructured supergydrophobic surfaces显示文摘 | TAOLEY SUN HONG TAN DONG HAN | 2005 | Small2005，1，10： | 1 |
| 16 | Smart Surface of Water-induced Superhydrophobicity显示文摘 | Qing G Jiang Lei Sun Taolei | | 0，，19： | 1 |
| 17 | Dual-responsive Surfaces that Switch Between Superhydrophilicity and Superhydrophobicity显示文摘 | Xia F Sun Taolei J iang Lei | | 0，，： | 1 |
| 18 | Nucleotide-responsive Wettability on a Smart Polymer Surface显示文摘 | Qing G Wang Xing Sun Taolei | | 0，，： | 1 |
| 19 | Saccharide-sensitive Wettability Switching on a Smart Polymer Surface显示文摘 | Qing G Wang Xing Sun Taolei | | 0，，5： | 1 |
| 20 | A study of interfacial dilational properties of two different structure demulsifiers at oil - water interfaces 显示文摘 | Wang Yiyang Zhang Lu Sun Taolei | 2004 | Journal of Colloid and Interface Science2004，16，2： | 1 |
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