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| 1 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 2 | Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis Georgi显示文摘 | Sasaki K Taura F Shoyama Y | 2000 | J Biol Chem2000，275，27： | 1 |
| 3 | An early phase Ⅱ study of a 3 - hour infusion of paclitaxel for advanced gastric cancer 显示文摘 | Obtsu A Boku N Taura F | 1998 | Am J Clin Oncol1998，21，4： | 1 |
| 4 | Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa显示文摘 | Taura F Sirikantaramas S Shoyama Y | 2007 | FEBS Lett2007，581，16： | 1 |
| 5 | Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants 显示文摘 | Putalun W Taura F Qing W | 2003 | Plant Cell Rep2003，22，： | 1 |
| 6 | Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L显示文摘 | TAURA F MORIMOTO S SHOYAMA Y | 1996 | The Journal of Biological Chemistry1996，271，17： | 1 |
| 7 | Anti-solasodine glycoside single-chain Fv antibody stimulates of solasodine glycoside in plants显示文摘 | Putalun W Taura F Qing W | 2003 | Plant Cell Rep2003，22，5： | 1 |
| 8 | Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleusforskohlii Briq显示文摘 | ENGPRASERT S TAURA F KAWAMUKAI M | 2004 | BMC Plant Biol2004，18，4： | 1 |
| 9 | Transcriptional activation of a geranylgeranyl diphosphate synthase gene, GGPPS2, isolated from Scoparia dulcis by treatment with methyl jasmonate and yeast extract显示文摘 | Yamamura Y Mizuguchi Y Taura F | 2014 | Journal of Natural Medicines2014，68，4： | 1 |
| 10 | Molecular clo- ning and functional expression of geranylgeranyl pyrophos- phate synthase from Coleus forskohlii Briq 显示文摘 | Engprasert S Taura F Kawamukai M | 2004 | BMC Plant Biology2004，4，： | 1 |
| 11 | Molecular cloning, expression and characterization of recombinant 1-deoxy-D-xylulose-5-phosphatereductoisomerase from Coleus forskotdii Briq显示文摘 | ENGPRASERT S TAURA F SHOYAMA Y | 2005 | Plant Science2005，169，： | 1 |
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