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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | 器官移植受体发生EBV阳性的皮肤黏膜溃疡:一种局限性惰性移植后淋巴组织增殖性疾病显示文摘Epstein-Barr 病毒( EBV )阳性的皮肤黏膜溃疡( EBV MCU)是在老人或医源性免疫受损患者中发生的一种B细胞淋巴组织增殖性疾病,尚未见发生于实体器官移植受者的报道。作者在70例EBV阳性移植后淋巴组织增殖性疾病( PTLD)患者中发现7例EBV阳性MCU。包括5例肾脏、1例心脏和1例肺脏移植,其中男性5例。患者中位年龄61岁,4例发生于口腔黏膜,3例发生于胃肠道。溃疡病变发生前患者接受免疫抑制治疗0.6-13年。溃疡由炎症细胞和多形性或单形性大细胞增生,破坏皮肤黏膜而形成。5例中可见Reed-Sternberg样细胞。所有病例CD20、CD30阳性,原位杂交EBER结果阳性。3例近期患者被诊断为EBV阳性MCU,4例患者前期被诊断为单形性大细胞PTLD(n=3)和多形性 PTLD ( n =1)。所有患者血液 EBV DNA 均阴性(〈1000拷贝数/ml),而在诊断或随访的44例移植患者中有35例发生系统性 PTLD ( P 〈0.001)。所有 EBV 阳性MCU患者通过减少免疫抑制剂用量(7/7),调整免疫抑制剂用量(2/7),和联用利妥昔单抗(3/7)等使皮损得到治愈。目前5例存活:其中4例身体健康,1例在等待肾移植手术;另2例分别在EBV阳性MCU治愈后的3年和5年死亡。未发现EBV阳性MCU复发或其他PTLD。 | Hart M Thakral B Yohe S 胡舜摘 余英豪 | 2014 | 临床与实验病理学杂志2014，30，12： | 5 |
| 3 | Eudragit S-100entrapped chitosan microspheres of valdecoxib for colon cancer显示文摘 | Thakral NK Ray AR Majumdar DK | 2010 | J Mater Sci Mater Med2010，21，9： | 1 |
| 4 | Hepatitis Evirus显示文摘 | Panda SK Thakral D Rehman S | 2007 | Rev Med Virol2007，17，： | 1 |
| 5 | Successful management of pregnancy-associated severe aplastic ane- mia显示文摘 | THAKRAL B SALUJA K SHARMA R R | 2007 | Eur J Obstet Gynecol Reprod Biol2007，131，2： | 1 |
| 6 | Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases 显示文摘 | Coen J J Zietman AL Thakral H et el | 2002 | J Clin Oncol2002，20，15： | 1 |
| 7 | Congenital lobar em- physema and sequestration treatment by embolization显示文摘 | Nayar P M Thakral C L Sajwani M J | | Pe- diatr Surg Int0，21，9： | 1 |
| 8 | Severe ABO hemolytic disease of new born with a positive direct an tiglobulin tes 显示文摘 | Marwaha N Dhawan H Thakral B | 2009 | t Indian J Patho-1 Microbiol2009，52，2： | 1 |
| 9 | Hemolytic disease of new-born due to anti-Jkb in a woman with high risk pregnancy 显示文摘 | Thakral B Malhotra S Saluja K | 2010 | Transfus Apher Sci2010，43，1： | 1 |
| 10 | Acute haemolytic transfusion reaction by Le (a) alloantibody 显示文摘 | THAKRAL B JAIN A SALUJA K | 2006 | Am J Hematol2006，81，： | 1 |
| 11 | Interlocking plates for the treatment of proximal humerus fracture显示文摘 | M Ashraf M Hussain R Thakral | 2006 | J Bone and Joint Surgery (British)2006，87，2： | 1 |
| 12 | Therapeutic plateletpheresis in a case of symptomatic thrombocytosis in chronic myeloid leukemia显示文摘 | THAKRAL B SALUJA K MALHOTRA P | 2004 | Ther Apher Dial2004，8，6： | 1 |
| 13 | Successful management of pregnancy-associated severe aplastic anemia显示文摘 | Thakral B Saluja K Sharma RR | | 0，，： | 1 |
| 14 | Algorithm for recall of HIV reactive Indian blood donors by sequential immunoassays enablesselective donor referral for counseling显示文摘 | Thakral B Marwaha N | 2006 | Postgrad Med2006，52，2： | 1 |
| 15 | Replication of a recombinant hepatitis E virus genome tagged with reporter genes and generation of a short-term cell line producing viral RNA and proteins显示文摘 | Thakral D Nayak B Rehman S | 2005 | J Gen Virol2005，86，4： | 1 |
| 16 | Arthroscopic technique for treatment of combined pathology associated with femoroacetabular impingement syndrome using traction sutures and a minimal capsulotomy显示文摘 | Thakral R Ochiai D | 2014 | Arthrosc Tech2014，3，4： | 1 |
| 17 | Hepatitis E virus显示文摘 | Panda S K Thakral D Rehman S | 2007 | RevMedVirol2007，17，3： | 1 |
| 18 | Comparison of early onset nasoalveolar molding with patients who presented for molding up to 1year of age显示文摘 | Shetty V Thakral A Sreekumar C | 2016 | J Oral Maxillofac Surg2016，74，4： | 1 |
| 19 | First report from India of haemolytic disease of new born by anti-C and anti-E in Rh (D) positive mothers 显示文摘 | Thakral B Agrawal SK Dhawan HK | 2007 | Hematology2007，12，5： | 1 |
| 20 | Urea coinclusion compounds of 13 cis-retino- ic acid for simultaneous improvement of dissolution profile, photostability and safe handling characteristics 显示文摘 | ] THAKRAL S MADAN A K | | Journal of Pharmacy and Pharma- cology0，60，： | 1 |
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