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| 1 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 2 | A case-controlled study of laparoscopic compared with open lateral adrenalectomy 显示文摘 | Tsuneo I Toyone K Mikinao O | 1999 | Am J Surg1999，178，1： | 1 |
| 3 | Comparison of paralytic shellfish poisoning toxin between carnivorous crabs (Telmessus acutidens and Charybdis japonica) and their prey mussel (Mytilus galloprovincialis) in an inshore food chain显示文摘 | HIROSHI O TSUNEO F KEN S | 2004 | Toxicon2004，43，： | 1 |
| 4 | An ATP-sensitive potassium channel opener, nicorandil, lowers the threshold for ischemic pre- conditioning in barbital-anesthetized dogs显示文摘 | Tsuneo M Satoshi S Yukio O | 1997 | Heart Vessels1997，12，： | 1 |
| 5 | Laparoscopic radical nephrectomy for renal cell carcinoma:a five year experience显示文摘 | Yoshinari O Tsuneo K Ryohei H | 1999 | Urology1999，53，2： | 1 |
| 6 | Laparoscopic radical nephrectomy for renal cell carcinoma: a five-year experience 显示文摘 | Yoshinari O Tsuneo K Ryohei H | 1999 | Urology1999，53，2： | 1 |
| 7 | Maintenance of protozoa and methanogens, and fiber digestion rumensimulating continuous culture显示文摘 | TSUNEO H MASATOSHI S KOHJI O | 1993 | J Gen Appl Microbiol1993，39，： | 1 |
| 8 | Long - lived Vocanism on the Lunar Farside ReveaLed by SELENE Terrain Camera显示文摘 | Junichi H Makiko O Tsuneo M | 2009 | Science2009，323，： | 1 |
| 9 | Alismolandalimoxide,sesquiterpenoidsof Alisma Rhizomes显示文摘 | Yoshitem O Tsuneo I Hiroshi H | 1983 | Pytoehemistry1983，22，： | 1 |
| 10 | Densitision of aintered TiAl containing Cr by HIPing and their HIPed microstructures显示文摘 | YUJI M TSUNEO O HIROO S | 1994 | Powder & Powder Metallurgy1994，41，11： | 1 |
| 11 | The facile synthesis of 5'-nucleotides by the selective phosphorylation of group of nucleosides with phosphoryl chloride显示文摘 | Tsuneo S Shunji O | 1975 | Bull Chem Soc Jan1975，48，7： | 1 |
| 12 | Alismol and alismox- ide, sesquiterpenoids of Alisma rhizomes 显示文摘 | Yoshitem O Tsuneo I Hiroshi H | 1983 | Phytochem- istry1983，22，1： | 1 |
| 13 | Densitision of sintered TiAl containing Cr by HIP and their HIP microstructures显示文摘 | YUJI M TSUNEO O HIROO S | 1994 | Powder &Powder Metallurgy1994，41，11： | 1 |
| 14 | Construction of a threedimensional, largescale shaking table and development of core technology 显示文摘 | Nobuyuki O Keiichi O Tsuneo K | 2001 | Philosophical Transactions of the Royal Society A: Mathematical Physical and Engineering Sciences2001，359，17： | 1 |
| 15 | The carbon monoxide-binding pigment of liver microsomes显示文摘 | Tsuneo O Ryo S | 1964 | J Biol Chem1964，239，7： | 1 |
| 16 | Caspase-dependent apoptosis induced by calcineurin inhibitors was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical cells显示文摘 | Takao O | 2007 | Brain Research2007，1133，： | 1 |
| 17 | Isolation and characterization of elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces 显示文摘 | Hiroie O Tsuneo S Juichi A | 1978 | J Antibiot1978，31，11： | 1 |
| 18 | Laparoscopic radical nephrectomy for renal cell carcinoma: a five year experience 显示文摘 | Yoshinari O Tsuneo K Ryohei H | 1999 | Urology1999，53，： | 1 |
| 19 | Endogenous poly- amines in the pericarp and seed of the grape berry dur- ing development and ripening显示文摘 | Shu ji S Tsuneo O Shosaku H | 2000 | Scientia Horticultu- rae2000，，83： | 1 |
| 20 | Isolation and Characterization of Elasnin,a New Human Granulocyte Elastase Inhibitor Produced by a Strain of Streptomyces显示文摘 | HIROIE O TSUNEO S JUICHI A | 1978 | J Antibiotics1978，31，11： | 1 |
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