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| 1 | OTU deu- biquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis 显示文摘 | TYCHO E T M MANUELA K H PAUL P G | 2013 | Cell2013，154，： | 1 |
| 2 | Resistance to TRAIL - induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase - 8 expression 显示文摘 | Michael A Grotzer Angelika Eggert Tycho J Zuzak | 2000 | Oncogene2000，19，： | 1 |
| 3 | Contribution of volume overload and angiotensinⅡto the increased pulse wave velocity of hemodialysis patients显示文摘 | Tycho Vuurmans JL Boer WH Bos WJ | 2002 | J Am Soc Nephrol2002，13，1： | 1 |
| 4 | Realizable universal quantum logic gates 显示文摘 | Tycho Sleator Harald Weinfurter | 1995 | Physics Review Letter1995，74，： | 1 |
| 5 | Derivation of a Monte Carlo method for modeling heterodyne detection in optical coherence tomography systems显示文摘 | TYCHO A JOGENSEN T M YURA H T | | 0，，31： | 1 |
| 6 | Point set labeling with sliding labels显示文摘 | Tycho Strijk and Alexander Wolff | 1999 | Computational Geometry: Theory and Application 13(1999)1999，2147，： | 1 |
| 7 | Posterior lumbar interbody fusion versus posterolateral fusion in adult isthmic spondylolisthesis显示文摘 | Per E Hans M Tycho T | 2007 | Spine2007，32，20： | 1 |
| 8 | Prodrugs:design andclinical applications显示文摘 | Jarkko R Hanna K Tycho H | 2008 | Nature Reviews Drug Discovery2008，7，： | 1 |
| 9 | Reactivity of a new class of P450 enzyme models 显示文摘 | Dominik Meyer Tycho Leifels Laura Sbaragli | 2005 | Biophys Res Commun2005，338，1： | 1 |
| 10 | Derivation of a Monte Carlo method for modeling heterodyne detection in optical coherence tomography systems显示文摘 | A Tycho T M Jogensen H T Yura | 2002 | Applied Optics2002，41，31： | 1 |
| 11 | Transmural Myocardial Mechanics During Isovolumic Contraction显示文摘 | Hiroshi Ashikaga Tycho I.G. van der Spoel Benjamin A. Coppola Jeffrey H. Omens | 2009 | JACC: Cardiovascular Imaging2009，，2： | 1 |
| 12 | Contribution of volume overload and angiotensin Ⅱ to the increased pulse wave velocity of hemodialysis patients显示文摘 | Tycho Vuurmans JL Boer WH Bos WJ | 2002 | J Am Soc Nephrol2002，13，1： | 1 |
| 13 | Microencapsulation decreases the skin absorption of N , N -diethyl- m -toluamide (DEET)显示文摘 | Gerald B. Kasting Varsha D. Bhatt Tycho J. Speaker | 2007 | Toxicology in Vitro2007，，2： | 1 |
| 14 | α‐Blockers to assist stone clearance after extracorporeal shock wave lithotripsy: a meta‐analysis显示文摘 | YefangZhu DiederickDuijvesz Maroeska M.Rovers Tycho M.Lock | 2010 | BJU International2010，，2： | 1 |
| 15 | A multilevel pan-cancer map links gene mutations to cancer hallmarks显示文摘Background:A central challenge in cancer research is to create models that bridge the gap between the molecular level on which interventions can be designed and the cellular and tissue levels on which the disease phenotypes are manifested.This study was undertaken to construct such a model from functional annotations and explore its use when integrated with large-scale cancer genomics data.Methods:We created a map that connects genes to cancer hallmarks via signaling pathways.We projected gene mutation and focal copy number data from various cancer types onto this map.We performed statistical analyses to uncover mutually exclusive and co-occurring oncogenic aberrations within this topology.Results:Our analysis showed that although the genetic fingerprint of tumor types could be very different,there were less variations at the level of hallmarks,consistent with the idea that different genetic alterations have similar functional outcomes.Additionally,we showed how the multilevel map could help to clarify the role of infrequently mutated genes,and we demonstrated that mutually exclusive gene mutations were more prevalent in pathways,whereas many co-occurring gene mutations were associated with hallmark characteristics.Conclusions:Overlaying this map with gene mutation and focal copy number data from various cancer types makes it possible to investigate the similarities and differences between tumor samples systematically at the levels of not only genes but also pathways and hallmarks. | Theo A.Knijnenburg Tycho Bismeijer Lodewyk F.A.Wessels llya Shmulevich | 2015 | Chinese Journal of Cancer2015，34，10： | 0 |
| 16 | 手机拍摄日食攻略显示文摘2020年6月21日发生了难得一见的日环食。除了直接观测,拍摄可能是另一部分人的需求:现在的手机拍摄功能,已经完全能够满足拍摄日食的基本需求了。那么,如何把这个珍贵的一刻记录下来,炫爆朋友圈呢?下面,就向大家详细介绍一下用手机拍摄的主题和方法. | 冷冰川tycho(文/图) 袁凤芳(文/图) | 2020 | 中国国家天文2020，，6： | 0 |
| 17 | Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods显示文摘Magnesium as biodegradable biomaterial could serve as bone augmentation material in implant dentistry.The knowledge about the predictability of the biodegradation process is essential as this process needs to go hand in hand with the formation of new bone to gradually replace the augmentation material.Therefore,this work aimed to assess if the electrochemistry(EC)measurements of the corrosion process correlate with the surface features at various time points during the surface degradation,in order to describe the degradation process of Mg and Mg alloys more reliably,under the assumption that differences in EC behavior can be detected and related to specific patterns on the surface.In this test setup,a special optical chamber was used for electrochemical measurements on Mg and Mg-alloys(Mg2Ag,Mg4Ag,and Mg6Ag).Specimens were investigated using different circulating cell culture solutions as electrolytes,these were minimum essential medium(MEM),Hank’s Balanced Salt Solution(HBSS),and MEM+(MEM with added sodium hydrogen carbonate)at 37℃.Open circuit potential measurements(OCP)over 30 min followed by cyclic polarization were performed.The electrochemistry data,including OCP,exchange current density and corrosion potential,were compared with visible changes at the surface during these treatments over time.The results show that the addition of silver(Ag)leads to a“standardization”of the degradation regardless of the selected test medium.It is currently difficult to correlate the visible microscopic changes with the data taken from the measurements.Therefore,further investigations are necessary. | Yuqiuhan Zhang Tycho Zimmermann Wolf-Dieter Mueller Frank Witte Florian Beuer Andreas Schwitalla | 2022 | Bioactive Materials2022，7，1： | 0 |
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