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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 3 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 4 | Antagonisms among streptococci isolated from human oral cavity显示文摘 | DONGHUE H D TYLER J E | 1975 | Arch Oral Biol1975，20，： | 1 |
| 5 | Temperature-profile methods for estimating percolation rates in arid environ- ments显示文摘 | Constantz J Tyler S W Kwieklis E | 2003 | Vadose Zone Journal2003，2，1： | 1 |
| 6 | Hematologic and semen quality changes in bulls with experimental eperythrozoon infection显示文摘 | WELLES E G TYLER J W WOLFE D F | 1995 | Teriogenology1995，43，： | 1 |
| 7 | Eperythro-zoon infection in young bulls with scrotal and hindlimb edema,a herd outbreak显示文摘 | WELLES E G TYLER J W WOLFE D F | 1995 | Teriogenology1995，43，： | 1 |
| 8 | Solute movement instructured soils: two-region model with small interaction显示文摘 | Skopp J Gardner W R Tyler E J | 1981 | Soil Science Society of America Journal1981，45，5： | 1 |
| 9 | Trends in Wheat-Flour Fortification with Folic Acid and Iron - Worldwide, 2004 and 2007显示文摘 | Maberly G Grummer-Strawn L Jefferds M E Pe?a-Rosas J P Serdula M K Tyler V Q Berry R J Mulinare J Parvanta I Aburto N J | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，1： | 1 |
| 10 | Maximum likelihood identification of aircraft stability and control derivatives 显示文摘 | Mehra R K Stepner D E Tyler J S | 1974 | Journal of Aircraft1974，11，2： | 1 |
| 11 | Complex interactions between autotrophs in shallow marine and freshwater ecosystems:implications for community responses to nutrient stress显示文摘 | HAVENS K E HAUXWELL J TYLER A C | 2001 | Environment Poll2001，113，： | 1 |
| 12 | To- ward terabit-per-second capacities over multimode fi- ber links using SCM/WDM techniques显示文摘 | TYLER E J KOURTESSIS P WEBSTER M | 2003 | Journal of Lightwave Technology2003，21，3： | 1 |
| 13 | Penalty free subearrier modulated multimode Fiber links for data- comm application beyond the bandwidth limit 显示文摘 | TYLER E J WEBSTER M PENTY R V | 2002 | IEEE Photonics Technology Letters2002，14，1： | 1 |
| 14 | Clinical and clinicopathologic changes in cow with endotoxin induced mastitis treated with small volumes of isotonic or hypertonic sodium chloride administered intravenously 显示文摘 | Welles E G Ershine R J | 1994 | Am J Vet Res1994，55，： | 1 |
| 15 | Toward terabit-per-second capacities over multimode fiber links using SCM/ WDM techniques显示文摘 | Tyler E J Kourtessis P Webster M | 2003 | J Lightwave Teehnol2003，21，： | 1 |
| 16 | Scattering properties of distilled and natural waters显示文摘 | TYLER J E | 1961 | Limnol Oceanogr1961，6，： | 1 |
| 17 | A Three-Wave FDTD Approach to Surface Scattering with Applications to Remote Sensing of Geophysical Surfaces显示文摘 | WONG P B TYLER G L BARON J E | | 0，，04： | 1 |
| 18 | A three-wave FDTD approach to surface scattering with applications to remote sensing of geophysical surface显示文摘 | Wong P B Tyler G L Baron J E | 1996 | IEEE Trans on Antennas and Propagation1996，44，4： | 1 |
| 19 | Penalty free subcarrier modulated multimode Fiber links for dataeomm application hevnnd the bandwidth limit显示文摘 | Tyler E J Webster M Penty R V | 2002 | IEEE Photonics Technology Letters2002，14，1： | 1 |
| 20 | Procedural context and culture显示文摘 | Lind E A Tyler T R Huo Y J | 1997 | Journal of Personality and Social Psychology1997，73，4： | 1 |
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