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| 1 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 2 | Hyperbaric oxygen in the treatment of elevated intracranial pressure after head injury, Pediatr显示文摘 | Brown J A PREUL M C TAHA A | 1988 | Neurosci1988，14，： | 1 |
| 3 | Structure development in solidified alloys 显示文摘 | Taha M A Mahallawy N A Abdel-Rehim M | 1983 | Metall1983，37，8： | 1 |
| 4 | Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy显示文摘 | TAHA A S ANGERSON W J KNILL-JONES R P | 2006 | Aliment Pharmacol Ther2006，23，4： | 1 |
| 5 | Electrochemical behavior of Sn - Ni nanostructured compound in alkaline media and the effect of halide ions 显示文摘 | Refaey S A M Taha F A Hasanin T H | 2004 | Applied Surface Science2004，227，： | 1 |
| 6 | Corrosionand Inhibition of Stainless Steel Pitting Corrosion in Alka- line Medium and the Effect of C1- and Br- Anions 显示文摘 | REFAEY S A M TAHA F EL-MALAK A M A | 2005 | Ap- plied Surface Science2005，242，12： | 1 |
| 7 | Passivation and pitting corrosion of nanostructured Sn-Ni alloy in NaCl solutions显示文摘 | Refaey S A M Taha F A Hasanin T H | 2006 | Electrochimica Acta2006，51，： | 1 |
| 8 | Incidence of vascular malformations in spontaneous intra-cerebral haemorrhage in children显示文摘 | Papadias A Taha A Sgouros S | 2007 | Childs Nerv Syst2007，23，8： | 1 |
| 9 | Availability of barley straw application on oil spill clean up 显示文摘 | HUSSEIEN M AMER A A EL-MAGHRABY A TAHA N A | 2009 | International Journal of Environmental Science and Technology2009，6，1： | 1 |
| 10 | Prediction of safety factor for slope designed with various limit equilibrium methods显示文摘 | Mohamed T Kasa A Taha M R | 2011 | Key Engineering Materials2011，，： | 1 |
| 11 | Chemo-rheological study of a dicymmte ester for the simulation of the resin transfer molding process 显示文摘 | Maazouz A Texier C Taha M | 1998 | Composites Science and Technology1998，58，5： | 1 |
| 12 | Pre-oxygenation:comparison of maximal breathing and tidal volume breathing techniques显示文摘 | BARAKA A S TAHA S K AOUAD M T | 1999 | Anesthesiology1999，91，3： | 1 |
| 13 | Metal-matrix fabricated by pressure-assisted infiltration of loose ceramic powder 显示文摘 | Moharned A Taha Nahed A El-Mahallawy | 1998 | Joural of Materials Processing Technology1998，73，： | 1 |
| 14 | Near-Field Optics:From Subwavelength Illumination to Nanometric Shadowing显示文摘 | LEWIS A TAHA H STRINKOVSKI A | 2003 | Nat Biotechnol2003，21，11： | 1 |
| 15 | Spectroscopic studies on chromotropic mixed-ligand copper(II) complexes containing o-hydroxy benzoyl derivatives and dinitrogen bases显示文摘 | TAHA A | 2003 | Spectroehem Acta A2003，59，： | 1 |
| 16 | Chemo-rheological study of a dicyanate ester for the simulation of the resin transfer molding process显示文摘 | Maazouz A Texier C Taha M Alglave H | 1998 | Composites Science and Technology1998，58，： | 1 |
| 17 | A study of annealing stage in AI-Mn (3004) alloy after cold rolling using positron annihilation lifetime technique and Vickers microhardness measurements显示文摘 | GOMAA E MOHSEN M TAHA A S | 2003 | Materials Science and Engineering A2003，362，12： | 1 |
| 18 | Classification of in-flight catering wastes in Egypt air flights and its potential as energy source (chemical approach) 显示文摘 | EL-MOBAIDH A M TAHA M A R LASSHEEN N K | 2006 | Waste Management2006，26，6： | 1 |
| 19 | Effect of dehydroepiandrosterone (DHEA) on monoamine oxidase activity,lipid peroxidation and lipofuscin accumulation in aging rat brain regions显示文摘 | Kumar P Taha A Sharma D | 2008 | Biogerontology2008，9，4： | 1 |
| 20 | Mechanical,Fracture,and Microstructural Investigations of Rubber Concrete显示文摘 | REDA TAHA M M EL-DIEB A S ABD EL-WAHAB M A | 2008 | Journal of Materials in Civil Engineering2008，20，10： | 1 |
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