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| 1 | UV Assisted Preliminary DNA Binding Studies and Single-crystal X-ray Structure of 4-{(4-Nitrophenyl-sulfonamido)methyl}cyclohexanecarboxylic Acid显示文摘A new sulfonamide, 4-{(4-nitrophenylsulfonamido)methyl}cyclohexanecarboxylic acid(C14H18N2O6S), has been synthesized by the reaction of tranexamic acid and 4-nitrobenzenesulfonyl chloride in basic medium at room temperature. The molecular structure was determined by FT-IR, NMR, elemental analysis and single-crystal X-ray technique. X-ray diffraction shows that the compound crystallizes in the monoclinic system, space group P21/c with a = 13.5980(7), b = 4.9877(2), c = 23.3878(13) ?, β = 93.254(3)o, Z = 4, V = 1583.67(14) ?3, μ = 0.237 mm-1, F(000) = 720, R = 0.0471 and w R = 0.1182. The molecules are related by inversion and paired into dimers via C–H···O interactions. The dimmers are interlinked due to strong N–H···O bonds, where O-atoms are of sulfonyl groups. The molecules are stabilized in the form of infinite two-dimensional network with base vectors [0 1 0] and [0 0 –1] in the plane(1 0 2). The existence of good intermolecular interactions suggests the biological importance of the synthesized molecule. The compound was screened for its interaction with FS-DNA using UV-visible spectroscopy. UV-visible spectroscopic results depict that the compound interacts with DNA by mixed binding mode intercalation along with hydrogen bonding. Negative values of ΔG(–23.34, –17.79 k J·mol-1) indicate spontaneity of the compound-DNA adduct formation. | MUHAMMAD Danish RABIA Ayub Butt MUHAMMAD Nawaz Tahir MUHAMMAD Ashfaq SYEDA Tahira Hafeez | 2017 | Chinese Journal of Structural Chemistry2017，36，5： | 3 |
| 2 | Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer显示文摘BACKGROUND Pancreatic cancer(PC)is one of the deadliest malignancies with an alarming mortality rate.Despite significant advancement in diagnostics and therapeutics,early diagnosis remains elusive causing poor prognosis,marred by mutations and epigenetic modifications in key genes which contribute to disease progression.AIM To evaluate the various biological tumor markers collectively for early diagnosis which could act as prognostic biomarkers and helps in future therapeutics of PC in Kashmir valley.METHODS A total of 50 confirmed PC cases were included in the study to evaluate the levels of carbohydrate antigen 19-9(CA 19-9),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),vascular endothelial growth factor-A(VEGF-A),and epidermal growth factor receptor(EGFR).Mutational analysis was performed to evaluate the mutations in Kirsten rat sarcoma(KRAS),Breast cancer type 2(BRCA-2),and deleted in pancreatic cancer-4(DPC-4)genes.However,epigenetic modifications(methylation of CpG islands)were performed in the promoter regions of cyclin-dependent kinase inhibitor 2A(p16;CDKN2A),MutL homolog 1(hMLH1),and Ras association domain-containing protein 1(RASSF1A)genes.RESULTS We found significantly elevated levels of biological markers CA 19-9(P≤0.05),TPS(P≤0.05),CEA(P≤0.001),and VEGF(P≤0.001).Molecular genetic analysis revealed that KRAS gene mutation is predominant in codon 12(16 subjects,P≤0.05),and 13(12 subjects,P≤0.05).However,we did not find a mutation in DPC-4(1203G>T)and BRCA-2(617delT)genes.Furthermore,epigenetic modification revealed that CpG methylation in 21(P≤0.05)and 4 subjects in the promoter regions of the p16 and hMLH1 gene,respectively.CONCLUSION In conclusion,CA 19-9,TPS,CEA,and VEGF levels were significantly elevated and collectively have potential as diagnostic and prognostic markers in PC.Global data of mutation in the KRAS gene commonly in codon 12 and rare in codon 13 could augment the predisposition towards PC.Additionally,methylation of the p16 gene could also modulate transcription of genes thereby increasing the predisposition and susceptibility towards PC. | Bilal Rah Manzoor Ahmad Banday Gh Rasool Bhat Omar J Shah Humira Jeelani Fizalah Kawoosa Tahira Yousuf Dil Afroze | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 3 | Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn显示文摘 | Murad Ali Khan Haroon Khan Sarwar Khan Tahira Mahmood Pir Mohammad Khan Abdul Jabar | 2009 | Journal of Enzyme Inhibition and Medicinal Chemistry2009，，3： | 2 |
| 4 | 血管紧张素受体拮抗剂对原发性高血压患者受损的内皮祖细胞功能的作用显示文摘内皮祖细胞(endothelial progenitor cells,EPC)可诱导形成新血管和修复损伤血管。业已证明,高血压大鼠的EPC功能受损,表现为氧化应激加重,而血管紧张素受体拮抗剂可改善受损的EPC功能。该研究调查正常血压对照组和高血压患者的EPC功能,以及氯沙坦对高血压患者受损的EPC功能的作用。方法: | Suzuki R Fukuda N Katakawa M Tsunemi A Tahira Y Matsumoto T Ueno T Soma M | 2014 | 中华高血压杂志2014，22，8： | 1 |
| 5 | Diamondoid hydrocarbons as maturity indicators for condensates from southern indus basin, Pakistan 显示文摘 | SHAGUFTA N TAHIRA F | 2013 | Journal of chemistry2013，46，68： | 1 |
| 6 | Potential threats involved in the decline of some medicinal plants of Margala hills显示文摘 | Rashid A Tahira A Gul J 1997 | 1997 | Islamabad Hamdard Medicus1997，11，4： | 1 |
| 7 | Effect of emulsifiers on complexation and retrogradation characteristics of native and chemically modified White sorghum ( Sorghum bicolor ) starch显示文摘 | Tahira Mohsin Ali Abid Hasnain | 2013 | Thermochimica Acta2013，，： | 1 |
| 8 | X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and Ravaz index显示文摘Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon scions.Viticultural traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed Tomography(CT)was used to measure ring widths in 103 vines.Ring width was modeled as a function of ring number using a negative exponential model.Early and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 traits.Modeling of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the vine.Ravaz index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk radius.Ultimately,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic traits.Rootstocks act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species. | ZoëMigicovsky Michelle Y.Quigley Joey Mullins Tahira Ali Joel F.Swift Anita Rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh Reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris Danielle R.Hopkins Lindsay M.Jordan Misha T.Kwasniewski R.Keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood | 2023 | Horticulture Research2023，10，1： | 1 |
| 9 | Synthesis, color fastness evaluation and utilization of humic acid derived dyes/pigment 显示文摘 | SAQIB N TAHIRA B KHALID M | 2011 | J Chil Chem Soc2011，56，1： | 1 |
| 10 | Antilmdy therapy for Alzheimer' s disease显示文摘 | Tahira T Matsumoto SE Jin H | 2011 | Rinsho Shinkeigaku2011，51，11： | 1 |
| 11 | Analysis of p53tumour suppressor gene somatic mutations in rheumatoid arthritis synovium显示文摘 | Inazuka M Tahira T Horiuchi T | 2000 | Rheumatology2000，39，3： | 1 |
| 12 | Effect of photoacid generator on surface wettability controllable polyimides by UV light irradiation 显示文摘 | Tsuda Y Tahira M Shinohara N | 2015 | Journal of Photopolymer Science and Technology2015，28，3： | 1 |
| 13 | Thalamic atrophy following cerebral infarction in the territory of the middle cerebral artery 显示文摘 | Tamura A Tahira Y Nagashima H | 1991 | Stroke1991，22，5： | 1 |
| 14 | Genetic and epigenetic alteration among three homoeologous genes of a class E MADS box gene in hexaploid wheat显示文摘 | Shitsukawa N Tahira C Kassai K | 2007 | Plant Cell2007，19，： | 1 |
| 15 | Evaluation of hypoglycemic and hypolipidemic activity of methanol extract of Brassica oleracea显示文摘AIM: The hypoglycemic and hypolipidemic effects of the methanol extract of Brassica oleracea var. capitata(MEB) was evaluated in alloxan-induced diabetic rabbits. METHOD: The study was conducted on twenty-eight healthy white rabbits of either sex. All animals were equally divided into four groups. After confirmation of hyperglycemia, the animals of the treated and standard groups were administered MEB(500 mg·kg-1) and glibenclamide(10 mg·kg-1), respectively for 15 and 30 days. The animals of the normal and diabetic controls received normal saline 1 mL/day equivalent to the volume of doses given to the test and standard animals. Biochemical tests were performed at the end of dosing, i.e. the 16 th and 31 st days. RESULTS: The MEB revealed a decrease of 106.6 mg·dL-1 in fasting blood glucose as compared to diabetic control, which was almost comparable to glibenclamide; both of these changes were highly significant. The decrease in total cholesterol and low density lipoprotein was 94.3 and 96.5 mg·dL-1, respectively, whereas the high-density lipoprotein was increased by 26.7 mg·dL-1, as compared to diabetic control. All of the changes in lipid profile were statistically significant. CONCLUSION: These results suggest the potential of MEB as a hypoglycemic and hypolipidemic agent. | Tahira Assad Rafeeq.A.Khan Zeeshan Feroz | 2014 | Chinese Journal of Natural Medicines2014，12，9： | 1 |
| 16 | Evolution of wave function in the two-photon Jaynes-Cummings model: The generation of superposition of coherent states显示文摘 | Tahira Nasreen Zaheer K | 1994 | Physics Review A1994，49，： | 1 |
| 17 | Effects of high temperature and/or controlling transpiration by bagging and/or spraying an anti-transpirant on the occurrence of watercore in Japanese pear 'Hosui'(Pyrus pyrifolia Nakai)显示文摘 | SAKUMA F KATAGIRI S TAHIRA K UMEYA T HIYAMA H | 2000 | Journal of the Japanese Society for Horticultural Science2000，69，3： | 1 |
| 18 | Transforming growth factor-beta expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension显示文摘 | Tahira Y Fukuda N Endo M | 2002 | Hypertens Res2002，25，6： | 1 |
| 19 | Dowling determination of rhodamine 123 in cell lysate by HPLC with visible wavelength detection显示文摘 | TAHIRA I MINORI K THOMAS C | 2005 | J Chrom B2005，814，2： | 1 |
| 20 | Transforming growth factor-beta as a treatment target in renal diseases 显示文摘 | Fukuda N Tahira Y Matsuda H | 2009 | J Nephrol2009，22，6： | 1 |
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