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| 1 | Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge显示文摘While the incidence of gastric cancer has decreased worldwide in recent decades,the incidence of signetring cell carcinoma(SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer,which can be resected endoscopically in some cases and which has a better outcome than non-SRCC,and advanced gastric cancer,which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However,the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified,as the benefit of perioperative chemotherapy and the value of taxanebased chemotherapy are unclear. In this review we analyze recent data on the epidemiology,oncogenesis,prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer. | Simon Pernot Thibault Voron Geraldine Perkins Christine Lagorce-Pages Anne Berger Julien Taieb | 2015 | World Journal of Gastroenterology2015，21，40： | 30 |
| 2 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 3 | 中国电力行业的演变:基于制度理论的分析显示文摘 | 田志龙 张泳 Taieb Hafsi | 2002 | 管理世界2002，18，12： | 19 |
| 4 | 介孔载体嫁接的离子液体催化二氧化碳合成碳酸丙烯酯显示文摘将离子液体1-丙基(三乙氧基硅基)-3-甲基咪唑的氢氧化物([Smim]OH)分别嫁接到介孔SiO_2、MCM-41和SBA-15分子筛上制备了非均相嫁接型离子液体,用傅里叶变换红外光谱、N_2吸附、元素分析和热重分析等技术对3种非均相嫁接型离子液体进行了表征。在无溶剂、温和的条件下,以非均相嫁接型离子液体为催化剂,研究了环氧丙烷(PO)与CO_2环加成合成碳酸丙烯酯的反应。实验结果表明,3种非均相嫁接型离子液体均具有较好的催化性能,[Smim]OH/SiO_2的催化性能最好;在[Smim]OH/SiO_2 1.260 mmol、PO 70 mmol、CO_22 MPa、120℃、8 h的优化反应条件下,PO的转化率可达99.5%;[Smim]OH/SiO_2重复使用4次后仍能保持较高的催化性能。 | 张学兰 Abdullah S N Al-Arifi Taieb Aouak Zeid Abdullah Al-Othman 魏伟 孙予罕 | 2009 | 石油化工2009，38，12： | 8 |
| 5 | Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma显示文摘This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative surgery.The potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial. | Nicolas Williet Olivier Dubreuil Tarek Boussaha Isabelle Trouilloud Bruno Landi Martin Housset Muriel Botti Philippe Rougier Jacques Belghiti Julien Taieb | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 6 | 我国四级政府创新政策体系下的企业响应策略与行动:基于扎根理论的多案例研究显示文摘企业如何响应创新政策是政府创新政策能否发挥作用的关键。本文以我国6家高新技术企业为研究对象,采用多案例研究方法和扎根理论来探索科技企业对我国中央、省、市、区/县四级政府创新政策及其体系的响应机制,并构建了'认知-策略-行动'理论模型。研究发现,企业不仅会从政策文本中看到政策资源,还能从四级政府创新政策的竞争体系中感知到政治压力和市场压力,并识别出产业信息。并且,不同企业对不同层级政府创新政策的认知水平不同,这种认知上的差异使得企业对不同层级政府创新政策采取不同的响应策略。 | 田志龙 陈丽玲 Taieb Hafsi 顾佳林 | 2021 | 管理评论2021，33，12： | 5 |
| 7 | Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection显示文摘BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly understood.This study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on hemodialysis.METHODS:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing hemodialysis.The patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis. | Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 8 | 京津地区流浪犬及家养犬消化道寄生虫感染调查显示文摘目的了解京津地区流浪犬及家养犬消化道寄生虫感染情况。方法 2016年6月-2017年7月采集京津地区家养犬及流浪犬粪便标本。采用醛醚沉淀法查寄生虫虫卵。结果流浪犬及家养犬消化道寄生虫总感染率为52.99%,其中流浪犬感染率为79.68%,家养犬感染率为22.56%,差异有统计学意义(χ~2=114.43,P<0.05)。犬消化道蠕虫、原虫感染率分别为39.32%和28.49%。蠕虫感染中犬钩虫、犬蛔虫、绦虫、华支睾吸虫感染率分别为25.64%、15.67%、0.57%和5.70%,优势种为犬钩虫和犬蛔虫。流浪犬犬钩虫、犬蛔虫、绦虫、华支睾吸虫、原虫感染率分别为45.99%、22.46%、0.68%、9.09%和40.64%,家养犬对应寄生虫感染率依次为2.44%、7.93%、0.61%、1.83%和14.63%,流浪犬犬钩虫感染率与家养犬比较差异有统计学意义(χ~2=86.91,P<0.05)。感染犬中多重感染占32.26%,流浪犬多重感染占比37.58%与家养犬多重感染占比10.81%比较差异有统计学意义(χ~2=9.72,P<0.05)。结论京津地区犬消化道寄生虫感染率较高,以流浪狗犬感染情况更为严重。 | 杨舒 孟超 楚旭 刘阳 Sahbi Khaled Taieb 路丹 崔博豪 陈莎 彭鹏 陈苓苓 纪伟华 胡立志 | 2017 | 中国病原生物学杂志2017，12，12： | 4 |
| 9 | Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's显示文摘AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) infection.METHODS: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy controls.RESULTS: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population. | Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 10 | Intensive systemic chemotherapy combined with surgery for metastatic colorectal cancer : results of a phase Ⅱ study 显示文摘 | Taieb J Artru P Paye F | 2005 | J Clin Oncol2005，23，3： | 1 |
| 11 | Anti-Mullerian hormone concentrations in the follicular fluid of the preovulatory follicle are predictive of the implantation potential of the ensuing embryo obtained by in vitro fertilization显示文摘 | Fanchin R Mendez LD Frydman N Gougeon A di Clemente N Frydman R Taieb J | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 12 | Efficacy of beta-blockers in infantile Haemangiomas: the physiopatological significance and therapeutic consequences显示文摘 | LeLabreze C Taieb A | 2008 | Ann Dermatol Venerol2008，135，12： | 1 |
| 13 | Asymmetric periflexural exanthem of childhood显示文摘 | Megraud F Legrain V | 1993 | J Am Acad Dermatol1993，29，： | 1 |
| 14 | A novel mutation in LPAR6 causes autosomal recessive hypotrichosis of the scalp 显示文摘 | Nahum S Morice-Picard F Taieb A | 2011 | Clin Exp Dermatol2011，36，2： | 1 |
| 15 | Profile and management of patients treated for the first time for lower urinary tract symptoms/benign prostatic hyperplasia in four European countries显示文摘 | Fourcade R O Theret N Taieb C ‘al | 2008 | BJU Int2008，101，9： | 1 |
| 16 | Reversal of dilated cardiomyopathy by the elimination of frequent left or right premature ventricular contractions 显示文摘 | Taieb JM Mamy P Shah D | 2007 | J Interv Card Electrophysiol2007，20，12： | 1 |
| 17 | Multiple- output modeling for multi-step-ahead time series forecasting 显示文摘 | Taieb S B Sorjamaa A Bontempi G | 2010 | Neurocomputing2010，73，19： | 1 |
| 18 | Vitiligo as an inflammatory skin disorder: a therapeutic perspective显示文摘 | TAIEB A | 2012 | Pigment Cell Melanoma Res2012，25，1： | 1 |
| 19 | The potential of exosomes in immunotherapy of cancer 显示文摘 | Chaput N Taieb J Schartz N | 2005 | Blood Cells Mol Dis2005，35，2： | 1 |
| 20 | Efficacy of beta-blockers in infantile hemangigomas: The physiopathological significance and therapertic consequences显示文摘 | Leaute-Labreze C Taieb A | 2008 | Ann Dermatol Venerol2008，135，12： | 1 |
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