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| 1 | Depression in patients with irritable bowel syndrome in Jos,Nigeria显示文摘AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions. | Nimzing G Ladep Taiwo J Obindo Moses D Audu Edith N Okeke Abraham O Malu | 2006 | World Journal of Gastroenterology2006，12，48： | 22 |
| 2 | Cardiac amyloidosis: A case report and review of literature显示文摘BACKGROUND Cardiac amyloidosis,a disease caused by the precipitation of amyloid proteins in the myocardial extracellular matrix has been historically difficult to diagnose due to lack of specific clinical manifestations and necessity of biopsy to demonstrate amyloid deposition. However,advances in cardiovascular imaging techniques have facilitated earlier recognition of this disease. In addition,while once thought of as incurable,treatment strategies are emerging for cardiac amyloidosis,making early diagnosis essential.CASE SUMMARY We outline the case of a 73 years old African American female who was admitted with sudden onset shortness of breath and found to be in cardiogenic shock.Cardiac amyloidosis was suspected due to discordance between electrocardiogram and echocardiogram findings and this was subsequently confirmed with the aid of scintigraphy and an endomyocardial biopsy.CONCLUSION Our objective is to highlight the diagnostic evaluation and clinical implications of cardiac amyloidosis. | Adeyemi Adedamola Taiwo Lavanya Alapati Assad Movahed | 2019 | World Journal of Clinical Cases2019，7，6： | 3 |
| 3 | Efficacy of praziquantel in the treatment of Schistosoma haematobium infection among school-age children in rural communities of Abeokuta, Nigeria显示文摘Background:Chemotherapy with praziquantel(PZQ)has been the cornerstone of schistosomiasis control over the last two decades.Being the only available drug for the treatment of over 200 million people worldwide,continuous monitoring of PZQ efficacy under the pressure of widespread use is therefore advocated.Methods:The efficacy of taking two doses of oral PZQ for the treatment of Schistosoma haematobium was examined among school children in Nigeria.Urine specimens were collected from 350 school children and examined using the filtration technique.Blood was collected for packed cell volume(PCV)estimation,and the weight and height of each child were estimated.S.haematobium egg positive pupils were treated with two oral doses of PZQ at 40 mg/kg with a four-week interval in between.Drug efficacy was determined based on the egg reduction rate(ERR).Results:Among 350 school children,245(70.0%)-of which 132 were males and 113 were females,with an age range of 4 to 15 years-were diagnosed with S.haematobium.All the 245 infected children received a single oral dose of 40 mg/kg PZQ twice with a four-week interval in between and were followed up for 12 weeks.At four,eight and twelve weeks post treatment,the ERR was 57.1%,77.6%and 100%,respectively.The ERR was significantly higher among the children with a light infection compared to those with a heavy infection.One hundred and twenty-one children were egg negative at four weeks post treatment,among which 1(6.3)and 120(52.4%)had heavy and light infections,respectively.Following the second round of treatment,the cure rate at eight weeks and twelve weeks was 85.3%and 100%,respectively.Conclusion:This study demonstrated the efficacy of taking two doses of oral PZQ for the treatment of urinary schistosomiasis among school children in Nigeria. | Olusola Ojurongbe Olawunwi Risqat Sina-Agbaje Abass Busari Patricia Nkem Okorie Taiwo Adetola Ojurongbe Akeem Abiodun Akindele | 2014 | Infectious Diseases of Poverty2014，3，1： | 3 |
| 4 | The blood-brain barrier models to study apolipoprotein E genotypes in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disease that is characterized by an age-dependent progressive decline of memory,impairment of cognitive functions and changes in personality and behavior.Despite the improvement in understanding of the mechanisms underlying the disease,AD remains an incurable complex disorder with multifaceted pathophysiology to date.Apolipoprotein E(ApoE)is the main cholesterol carrier in the brain that supports lipid transport between brain cells.The individuals carrying the APOE4 allele are known to be at increased risk of developing AD compared with those carrying the more common APOE3 allele. | Irundika HK Dias Rachelle Taiwo Dan Ma | 2022 | Neural Regeneration Research2022，17，9： | 2 |
| 5 | Evaluation of Antioxidant Potential of Melanthera scandens显示文摘 | Sunday Adeleke Adesegun Sukurat Olasumbo Alabi Patricia Taiwo Olabanji Herbert Alexander Babatunde Coker | 2010 | Journal of Acupuncture and Meridian Studies2010，，4： | 2 |
| 6 | Bacterial degradation of coal discard and geologically weathered coal显示文摘The biodegradation of coal discard is being intensively studied in South Africa in an effort to develop passive methods for the successful revegetation and rehabilitation of waste dumps, to mitigate pollution, and facilitate mine closure. Bacteria were isolated from slurries of coal tailings and diesel-contaminated soil, screened for coal biodegradation competence, characterized, and the colonization and degradation of coal discard and geologically weathered coal investigated using individual isolates and consortia. Ten novel coal-degrading bacterial strains were isolated and characterized, the gene sequences deposited with GenBank, and the (wild-type) strains deposited at Microbial Culture Collection, India. The results from the present work show that bituminous coal discard and geologically weathered coal is used by these isolates as carbon and energy source. Isolated strains and consortia colonized and degraded both coal substrates. Growth rate of the isolates is faster and stationery phase achieved sooner in minimal medium containing geologically weathered coal. This observation suggests that the oxygen-rich weathered coal is a more friable substrate and thus readily colonised and biodegraded. A reduction in mass of substrate is demonstrated for both individual isolates and consortia. The changes in pH and associated media colouration occurred concomitant with formation of humic acid-like (HS) and fulvic acid-like substances (FS) which is confirmed following analysis of these products by FT-IR spectroscopy. It is concluded that preferential metabolism of alkanes from the coal substrates provided the carbon and energy for bacterial growth and transformation of the substrates to HS and FS. | Jacob Taiwo Olawale Oghenekume Gerald Edeki Ashton Keith Cowan | 2020 | International Journal of Coal Science & Technology2020，7，2： | 2 |
| 7 | Osmotic dehydration of strawberry halves: influence of osmotic agents and pretreatment methods on mass transfer and product characteristics显示文摘 | TAIWO K A ESHTIAGHI M N ADE-OMOWAYE B I O | 2003 | International Journal of Food Science and Technology2003，，38： | 1 |
| 8 | Serotonin is a directly- acting hyperalgesic agent in the rat显示文摘 | Taiwo YO Leller PH Levine JD | 1992 | Neuroscience1992，48，2： | 1 |
| 9 | Sex differences in injury patterns among workers in heavy manufacturing 显示文摘 | Taiwo OA Cantley LF Slade MD | 2009 | Am J Epidemiol2009，169，2： | 1 |
| 10 | Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses显示文摘 | Taiwo YO Levine JD | 1988 | J Neurosci1988，8，4： | 1 |
| 11 | Selective concentration of EPA and DHA using Thermomyces lanuginosus tipase is due to fatty acid selectivity and not regioselectivity显示文摘 | Taiwo O A Jacqui L A Colin J B | 2013 | Food Chemistry2013，138，： | 1 |
| 12 | Effects of cyclooxygensse products of arachidonic acid metabolism on cutaneous nociceptive threshold in the rat显示文摘 | Taiwo OY Levine DJ | 1990 | Brain Res1990，537，： | 1 |
| 13 | Pathobiochemical mechanisms involved in the control of the disease caused by Trypanosoma congolense in African grey duiker ( Sylvicapra grimmia )显示文摘 | A.O. Ogunsanmi V.O. Taiwo | 2001 | Veterinary Parasitology2001，，： | 1 |
| 14 | Sex differences in injury patterns among workers in heavy manufacturing 显示文摘 | Taiwo O A Cantley L F Slade M D | 2009 | Am J Epidemiol2009，169，2： | 1 |
| 15 | Effects of pretreatments on the diffusion kinetics and some quality parameters of osmotically dehydrated apple slices 显示文摘 | Taiwo K A Angersbach A Adeomowaye S I O Knorr D | 2001 | Journal of agricultural and food chemistry2001，49，： | 1 |
| 16 | Use of pulsed electric field of plant based foods 显示文摘 | B I O Ade - Omowaye Apre - rt ea tmentt o improve Angersbach K A Taiwo | 2001 | Trends in Food Science & Technology2001，12，： | 1 |
| 17 | Antihyperalgesic effects of intrathecal neuropeptide Y during inflammation are mediated by Y1 receptors显示文摘 | Taiwo OB Taylor BK | | 0，，03： | 1 |
| 18 | Legal Naturalism: Marxist Theory of Law 显示文摘 | Olufemi Taiwo | 1995 | Comell University Press1995，，： | 1 |
| 19 | A two-Phase flow and non-isothermal agglomerate model for a proton exchange membrane(PEM) fuel cell 显示文摘 | Lei Xing Liu Xiaoteng Taiwo Alaje | 2014 | International Journal of Hydrogen Energy2014，73，5： | 1 |
| 20 | Prevalence of depression among adults in Oyo State, Nigeria : A comparative study of rural and urban Communities显示文摘 | Olorunfemi A Taiwo L Victor L | 2007 | Aust Rural Health2007，15，： | 1 |
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