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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum显示文摘 | YASUH IRO T SH HO I TAKU J IK | 2001 | Journal of Ethnopharmacology2001，77，23： | 1 |
| 3 | The matrix metalloproteinase regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer 显示文摘 | Taku T Michiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 4 | The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer显示文摘 | Taku T Miehiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 5 | Amelioration of delayed neuronal death in the hippocampus by nerve growth factor 显示文摘 | Taku S Tatsuo M Kintomo T | 1991 | J Neurosci1991，11，： | 1 |
| 6 | Isolation and analysis of the expression of two genes for the 81 - kilodalton heat shock proteins from Arabidopsis 显示文摘 | Taku T Satoshi N Yoshibumi K | 1992 | Plant Physiology1992，99，： | 1 |
| 7 | Studies on the internal gear hobs显示文摘 | TAKU U KENICHI T MASAFUMI S | 1975 | Bull of the JSME1975，18，115： | 1 |
| 8 | Amelioration of delayed neuronal death in the hippocampus by nerve growth factor显示文摘 | Taku S Tatsuo M Kintomo T | 1991 | J Neurosci1991，11，： | 1 |
| 9 | The membrane-anchored matrix meta1loproteinase regulator RECK in combination with MMP-9serves as an informative prognostic indicator for colorectal cancer显示文摘 | Taku T Michiyoshi H Mitsuo N | 2004 | Clin Cancer Rea2004，10，16： | 1 |
| 10 | IL-2 and IL-18 Attenuation of Airway Hyperresponsiveness Requires STAT4, IFN-, and Natural Killer Cells 显示文摘 | Shigeki M Katsuyuki T Taku K | 2007 | Am J Respir Cell Mol Biol2007，36，3： | 1 |
| 11 | Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis显示文摘 | Hideyasu S Taro M Kenichiro Y Taku H Manabu I Satoru T | 2004 | Circulation2004，110，： | 1 |
| 12 | Spermidine synthase genes are essential for survival of Arabidopsis 显示文摘 | Akihiro I Takashi M Yoshie H Takashi A Masanofi T Hikaru S Yumiko S Tomohiko K Hiroaki H Daisuke S Satoshi T Yoshibumi Taku T | 2004 | Plant Physiology2004，135，3： | 1 |
| 13 | Unique CD14^sup +^ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-[gamma] axis显示文摘 | Kamada Nobuhiko Hisamatsu Tadakazu Okamoto Susumu Chinen Hiroshi Kobayashi Taku Sato Toshiro Sakuraba Atsushi Kitazume Mina T Sugita Akira Koganei Kazutaka Akagawa Kiyoko S Hibi Toshifumi | 2008 | Journal of Clinical Investigation2008，，6： | 1 |
| 14 | The membrane-anchored matrix metalloproteinase regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer显示文摘 | Taku T Michiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 15 | The membrane-anchored matrix metalloproteinase regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer 显示文摘 | Taku T Michiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 16 | Primary hepatic choriocarcinoma in a 49-year-old man:Report of a case显示文摘We report a case of hepatic choriocarcinoma in a man diagnosed at autopsy after a rapid downhill clinical course.The patient was a 49-year-old man who presented with acute right-sided abdominal pain.There were no masses palpable on physical examination.Radiographic findings showed large multi-nodular tumors mainly in the right lobe of the liver.Fludeoxyglucosepositron emission tomography scan showed uptake only in the liver,and no uptake in the testes.We initially planned to perform a liver resection for the presumed diagnosis of intra-hepatic cholangiocarcinoma.However,the tumors grew rapidly and ruptured.Multiple lung metastases rapidly developed resulting in respiratory failure,preventing liver resection or even biopsy.He died 60 d after initial presentation with no pathological diagnosis.Postmortem studies included histopathological and immunohistological examinations which diagnosed a primary choriocarcinoma of the liver.Primary hepatic choriocarcinoma is very rare but should be considered in the differential diagnosis of a liver tumor in a middle aged man.Establishing this diagnosis may enable treatment of the choriocarcinoma.Liver biopsy and evaluation of serum human chorionic gonadotropin are recommended in these patients. | Ryosuke Sekine Masanobu Hyodo Masayuki Kojima Yoshiyuki Meguro Akifumi Suzuki Taku Yokoyama Alan T Lefor Norio Hirota | 2013 | World Journal of Gastroenterology2013，19，48： | 1 |
| 17 | The membrane- anchored matrix metalloproteinase regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer显示文摘 | Taku T Michiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
| 18 | Study on hob for cutting internal gears显示文摘 | TAKU U KENICHI T MASAFUMI S | 1974 | Journal of Engineering for Industry1974，，2： | 1 |
| 19 | Reactive ceramics of Ce02-Mox(M=Mn, Fe, Ni, Cu) for H2 generation by two-step water splitting using concentrated solar thermal energy显示文摘 | Kaneko H Muiura T Ishihar H Taku S Yokoyama T Nakajima H Tamaura Y | 2007 | Energy2007，32，： | 1 |
| 20 | The membrane- anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informa- tive prognostic indicator for colorectal cancer显示文摘 | Taku T Miehiyoshi H Mitsuo N | 2004 | Clin Cancer Res2004，10，8： | 1 |
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