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| 1 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 2 | Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong显示文摘 | Kc FWS Tam W Wong TW | 2007 | Thorax2007，62，9： | 1 |
| 3 | Smoking and tuber eulosis among the elderly in Hong Kong显示文摘 | Leung CC Li T Lain TH Yew WW Law WS Tam CM Chan WM Chan CK Ho KS Chang KC | 2004 | Am J Respir Crit Care Med2004，170，9： | 1 |
| 4 | Early pituitary-adrenal responses and retinopathy of prematurity in very low birth weight infants显示文摘 | Ng PC Kwok AK Lee CH Tam BS Lam CW Ma KC | 2004 | Pediatr Res2004，55，： | 1 |
| 5 | Chemoembolization agents for cancer treatment显示文摘 | Tam KY Leung KC Wang YX | 2011 | Eur J Pharm Sci2011，44，： | 1 |
| 6 | C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance显示文摘 | Tan KC Wat NM Tam SC | 2003 | Diabetes Care2003，26，8： | 1 |
| 7 | Tomographical imaging with limited angle input显示文摘 | Tam KC Perez-Mendes V | | 0，，05： | 1 |
| 8 | C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance显示文摘 | Tan KC Wat NM Tam SC | 2003 | Diabetes Care2003，26，8： | 1 |
| 9 | Atorvastatin lowers C - reactive protein and improves endothelium - dependent vasodilation in type 2 diabetes mellitus 显示文摘 | Chow WS Tam SC | 2002 | J Clin Endocrinol Metab2002，87，2： | 1 |
| 10 | Chemoembolization agents for cancer treatment显示文摘 | TAM KY LEUNG KC WANG YX | 2011 | Eur J Pharm Sci2011，44，12： | 1 |
| 11 | Association between acute-phase reactants and advanced glycation end products in type 2 diabetes显示文摘 | Tan KC Chow WS Tam S | 2004 | Diabetes Care2004，27，1： | 1 |
| 12 | Isothermal Titration Calorimetric Studies on Interactions of Ionic Surfactant and Poly(oxypropylene)-Poly(oxyethylene)-Poly(oxypropylene) Triblock Copolymers in Aqueous Solutions显示文摘 | Dai S Tam KC Li L | 2001 | Macromolecules2001，34，20： | 1 |
| 13 | Synthesis of amorphous calcium phosphate using various types of cyclodextrins 显示文摘 | Li YB Wiliana T Tam KC | 2007 | Materials Research Bulletin2007，5，： | 1 |
| 14 | Poly(N-isopropylacrylamide) latices prepared with sodium dodecyl sulfate显示文摘 | McPhee W Tam KC Pelton R | 1993 | J Colloid Interface Sci1993，156，1： | 1 |
| 15 | Chemoembolization agents for cancer treatment显示文摘 | TAM KY LEUNG KC WANG YX | 2011 | Eur J Pharm Sci2011，44，12： | 1 |
| 16 | Association between acute-phase reactants and advanced glycation end products in type 2 diabetes显示文摘 | Chow WS Tam S | 2004 | Diabetes Care2004，27，： | 1 |
| 17 | Incompletedata CT image reconstructions in industrial applications显示文摘 | Tam KC Eberhard JW Mitchell KW | | 0，，03： | 1 |
| 18 | Association between acute-phase reactants and advanced glycation end products in type 2 diabetes显示文摘 | Chow WS Tam S | 2004 | Diabetes Care2004，27，1： | 1 |
| 19 | Differences between odd and even number of response scale: some empirical evidence 显示文摘 | Wong CS Tam KC Fung MY | 1993 | Chin J Psychol1993，35，： | 1 |
| 20 | C- reactive protein predicts the deteioration of glycemia in Chinese subjects withimpaired glucose tolerance显示文摘 | Tan KC Wat nm Tam SC | 2003 | Diabetes Care2003，26，： | 1 |
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