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	题名	作者	年代	出处	被引量
1	Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production.	Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi	2014	World Journal of Gastroenterology2014，20，27：	4
2	Reverse engineering of geometric models—an introduction显示文摘	Tamás Várady Ralph R Martin Jordan Cox	1997	Computer-Aided Design1997，，4：	1
3	Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis显示文摘	Yee A Lam MP Tam V	2015	Osteoarthritis Cartilage2015，24，3：	1
4	An application of the AHP in vendor selection of a telecommunications system显示文摘	Tam C Y Tummala V M	2001	International Journal of Management Science2001，29，2：	1
5	Developing a risk assess- ment model for Construction Safety显示文摘	FUNG I W H TAM V W Y IX) T Y	2010	International Journal of Pro- iect Management2010，28，6：	1
6	An application of the AHP in vendor selection of a telecommunications system 显示文摘	Tam M C Y Tummala V M R	2001	O- mega2001，29，2：	1
7	Non-structural fuzzy decision support system for evaluation of construction safety management system 显示文摘	TAM C M TONG T K L CHIU G C V	2002	International Journal of Project Manage- ment2002，20，4：	1
8	An application of the AHP in vendor selection of a telecommunications system显示文摘	Tam M C Tummala V M	2001	Omega2001，29，2：	1
9	Cholera in vietnam:changes in genotypes and emergence of class Ⅰ integrons containing aminoglycoside resistance gene cassettes in vibrio cholerae ol strains isolated from 1979 to 1996显示文摘	DALSGAARD A FORSLUND A TAM N V	1999	J Clin Microbiol1999，37，3：	1
10	Parameters for assessing recycled aggregate and their correlation 显示文摘	Tam V W Y Tam C M	2009	Waste Management and Research2009，27，1：	1
11	Micro - structural analysis of recycled aggregate concrete produced from two - stage mixing approach显示文摘	TAM V W Y GAO X F TAM C M	2005	Cement and Concrete Research2005，35，6：	1
12	An application of the AHP in vendor sdection of a telecommunications system显示文摘	TAM M C TUMMALA V M	2001	Omega2001，29，2：	1
13	Reverse engineering of geometric models an introduction 显示文摘	Tamā Várady Ralph R Martin and Jordan Cox	1997	Computer-Aided Design1997，29，4：	1
14	Tissue engineering for intervertebral disk degeneration显示文摘	Leung VY Tam V Chan D		0，，04：	1
15	Green construction assessment for environmental management in the construction indus- try of Hong Kong显示文摘	Tam C M Tam V W Y Tsui W S	2004	International Journal of Project Management2004，22，7：	1
16	An Application of the AHP in Vendor Selection of a Telecommunications System显示文摘	TAM C Y TUMMALA V M	2001	Int J Manage Sci2001，29，2：	1
17	Recovery voice and satisfaction after service failure: an experimental investiga- tion of mediating and moderating factors 显示文摘	KARANDE K MAGNINI V P TAM L	2007	Journal of Service Research2007，10，3：	1
18	An application ofthe AHP in vendor selection of a telecommun-ications system显示文摘	TAM C Y TUMMALA V M	2001	Omega2001，29，2：	1
19	Fetal and adult human skin fibroblast display intrinsic differences in contractile capacity 显示文摘	MOULIN V TAM B Y CASTILLOUX G	2001	J Cell Physiol2001，188，2：	1
20	Green construction assessment for environmental management in the construction industry of Hong Kong 显示文摘	Tam C M Tam V W Y Tsui W S	2004	International Journal of Project Management2004，22，7：	1

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