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| 1 | Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study显示文摘AIM To assess the relationship between serum levels of insulin-like growth factor-1(IGF1)/IGF-binding protein-3(IGFBP3)and the risk of esophageal carcinoma.METHODS We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective,nested case-control study of participants from the Japan Collaborative Cohort Study.A baseline survey was conducted from 1988 to 1990.Of the 110585 enrolled participants,35%donated blood samples.Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies.A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.RESULTS Thirty-one cases and 86 controls were eligible for the present assessment.The molar ratio of IGF1/IGFBP3,which represents the free and active form of IGF1,was not correlated with the risk of esophageal carcinoma.A higher molar difference between IGFBP3and IGF1,which estimates the free form of IGFBP3,was associated with a decreased risk of esophageal carcinoma(P=0.0146),and people in the highest tertile had the lowest risk(OR=0.107,95%CI:0.017-0.669).After adjustment for body mass index,tobacco use,and alcohol intake,the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma(P=0.0150).CONCLUSION The free form of IGFBP3,which is estimated by this molar difference,may be inversely associated with esophageal cancer incidence. | Yasushi Adachi Masanori Nojima Mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi | 2017 | World Journal of Gastroenterology2017，23，19： | 4 |
| 2 | Nationwide epidemiological survey of chronic pancreatitis in Japan显示文摘 | Yingsong Lin Akiko Tamakoshi Seiki Matsuno Kazunori Takeda Tetsuo Hayakawa Motoji Kitagawa Satoru Naruse Takashi Kawamura Kenji Wakai Rie Aoki Masayo Kojima Yoshiyuki Ohno | 2000 | Journal of Gastroenterology2000，，2： | 2 |
| 3 | Clinical value of CA125, CA19-9, CEA, CA72-4, and TPA in borderline o- varian tumor 显示文摘 | Tamakoshi K Kikkawa F Shibata K | 1996 | Gynecol Oncol1996，62，1： | 1 |
| 4 | Maternal active and passive smoking and fetal growth: A prospective study in Nagoya, Japan显示文摘 | Matsubara F Kida M Tamakoshi A | 2000 | J Epidemiol2000，10，5： | 1 |
| 5 | The metabolic syndrome is associated with elevated circulting C-reactive protein in healthy reference range,a systemic low-grade inflammatory state显示文摘 | Tamakoshi K Yatsuya H Kondo T | 2003 | Int J Obes Relat Disord2003，27，4： | 1 |
| 6 | Prevalence ofidiopathic hypoparathyroidism and pseudohypoparathyroidism in Japan显示文摘 | Nakamura Y Matsumoto T Tamakoshi A | 2000 | J Epidemiol2000，10，： | 1 |
| 7 | Transcription profile of Thermus thermophilus CRISPR systems after phage infection显示文摘 | Agari Y Sakamoto K Tamakoshi M | 2010 | J Mol Biol2010，395，2： | 1 |
| 8 | The metabolic syndrome is associated with elevated circulating C -reactive protein in healthy reference range, a systemic low -grade inflammatory state显示文摘 | Yatsuya H Kondo T | 2003 | Int J Obes Relat Metab Disord2003，27，4： | 1 |
| 9 | Serum transforming growth factor - 131 levels and pancreatic cancer risk : a nested case - con- trol study (Japan) 显示文摘 | Lin Y Kikuchi S Tamakoshi A | 2006 | Cancer Causes Control2006，17，8： | 1 |
| 10 | Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men显示文摘 | Kunihiro Matsushita Hiroshi Yatsuya Koji Tamakoshi | 2006 | Arterioscler Thromb Vasc Biol2006，26，： | 1 |
| 11 | Low birth weight is associated with reduced adiponectin concentration in adult显示文摘 | Tamakoshi K Yatsuya H Wada K | 2006 | Ann Epidemiol2006，16，9： | 1 |
| 12 | Treatment of Common Bile Duct Obstruction by Pancreatic Cancer Using Various Stents: Single-Center Experience显示文摘 | Toshifumi Nakamura Ritsuko Hirai Mutsuo Kitagawa Yasunori Takehira Masami Yamada Katsutoshi Tamakoshi Yoshimasa Kobayashi Hirotoshi Nakamura Masao Kanamori | 2002 | CardioVascular and Interventional Radiology2002，，5： | 1 |
| 13 | Treatment of Common Bile Duct Obstruction by Pancreatic Cancer Using Various Stents: Single-Center Experience显示文摘 | Toshifumi Nakamura Ritsuko Hirai Mutsuo Kitagawa Yasunori Takehira Masami Yamada Katsutoshi Tamakoshi Yoshimasa Kobayashi Hirotoshi Nakamura Masao Kanamori | 2002 | CardioVascular and Interventional Radiology2002，，5： | 1 |
| 14 | Nationwide epfdemiological survey of chronic pancreatitis in Japan显示文摘 | Lfn Y Tamakoshi A tvlatsuno S et aI | 2000 | J Gastroenterol2000，35，2： | 1 |
| 15 | Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form显示文摘 | Kikkawa F Nawa A | 1995 | Cancer1995，76，12： | 1 |
| 16 | Nationwide epidemio-logical survey of chronic pancreatitis in Japan显示文摘 | Tamakoshi A Matsuno S | 2000 | J Gastroenterol2000，35，： | 1 |
| 17 | High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk显示文摘 | Matsushita K Yatsuya H Tamakoshi K | 2007 | Circ J2007，71，6： | 1 |
| 18 | The metabolie syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state显示文摘 | Tamakoshi K Yalsuya H Kondo T | 2003 | Int JObes Relat Metab Disord2003，27，4： | 1 |
| 19 | Evidence-based medicine and the cochrane collaboration显示文摘 | Tamakoshi A Wakai K | 1999 | Nippon Koshu Eisei Zasshi1999，46，6： | 1 |
| 20 | The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state显示文摘 | Tamakoshi K Yatsuya H Kondo T | 2003 | Int J Obes Ralat Metab Disord2003，27，4： | 1 |
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