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| 1 | 102例HIV-1感染者病毒株反转录酶基因多态性及耐药性变异研究显示文摘目的:目前中国未接受或已接受反转录酶抑制剂(RTI)治疗的HIV感染者的HIV反转录酶基因类型的数据较少。本研究探讨了HIV-1反转录酶的基因多态性,及在RTI选择性压力下出现的已知和未知变异位点。方法:分析研究21例未接受治疗及81例接受RTI治疗的HIV感染者的RT基因。大部分感染者(>80%)应用司他夫定(d4T)+地达诺新(ddI)+奈韦拉平(NVP)或d4T+拉米夫定(3TC)+依菲韦仑(EFV)三联HAART治疗方案。结果:在未接受治疗的患者中,发现了4个高度多态性位点(122、200、207和211)。在接受RTI治疗的患者中,发现了2种耐药相关变异(RAMs):①接受ddI+d4T+NVP治疗方案的患者中发现,K65R(9.8%)、L74V(7.4%)、M184V(7.4%)、Q151M(5%)和胸腺嘧啶类似物变异(TAMs)(9.3%),包括T215Y(5.5%);②接受d4T+3TC+EFV治疗方案的患者中发现,T215Y(23%)、M184V(20%)和TAMs(15.4%)。在所有病例中,非核苷反转录酶抑制剂(NNRTI)RAM的出现率很高(41.9%),而在142、221、224和228位点发现了4种可疑的新RAMs。结论:目前中国非核苷类反转录酶抑制剂(NNRTI)耐药相关变异十分普遍,本研究描述了RTI选择性变异的基因模式,提出了新的一些变异与RTI治疗的相关性。 | 刘莉 张云智 卢洪洲 Mireille Henry Catherine Tamalet | 2007 | 诊断学理论与实践2007，6，3： | 5 |
| 2 | Long-term nonprogressive human immunodeficiency virus-1infection in a kidney allograft recipient显示文摘 | Purgus R Tamalet C Poignard P | 1998 | Transplantation1998，66，10： | 1 |
| 3 | Relationship be- tween HPV 16, 18, 31, 33, 45 DNA detection and quan- titation and E6/E7 mRNA detection among a series of cervical specimens with various degrees of histolog显示文摘 | aron C Henry M Tamalet C | 2015 | J Med Virol2015，87，8： | 1 |
| 4 | 显示文摘 | Tamalet A Fauroux B | 1998 | Pediatr Pulmonol1998，26，5： | 1 |
| 5 | Long term effectsof azithromycin in patients with cystic fibrosis; a double blind,placebo controlled trial 显示文摘 | CLEMENT A TAMALET A LEROUX E | 2006 | Thorax2006，61，10： | 1 |
| 6 | Long term effects of azithromycin in patients with cystic fibrosis, a double blind, placebo controlled trial 显示文摘 | Clement A Tamalet A Leroux E | 2006 | Thorax2006，61，10： | 1 |
| 7 | Vaginal self-sam-pling is an adequate means of screening HR-HPV types inwomen not participating in regular cervical cancer screening显示文摘 | Tamalet C Le Retraite L Leandri FX | 2013 | Clin Microbiol Infect2013，19，1： | 1 |
| 8 | Resistance of HIV-1 to multiple antiretroviral drugs in France: a 6-year survey (1997- 2002) based on an analysis of over 7000 genotypes 显示文摘 | Tamalet C Fantini J Tourres C | 2003 | AIDS2003，17，16： | 1 |
| 9 | Effects of a combination of zidovudine, didanosine, and lamivudine on primary human immunodeficiency virus type I infection显示文摘 | Poggi C Tamalet C | 1997 | J Infect Dis1997，175，： | 1 |
| 10 | Acute and chronic hepatitis E in patients infected with human immunodeficiency virus显示文摘 | Colson P Dhiver C Poizot-Martin I Tamalet C Gerolami R | 2011 | J Viral Hepat2011，18，3： | 1 |
| 11 | Relationship between HPV 16, 18, 31, 33, 45 DNA detection and quantitation and E6/E7 mRNA detection among a series of cervical specimens with various degrees of histological lesions 显示文摘 | BARON C HENRY M TAMALET C | 2015 | J Med Virol2015，87，8： | 1 |
| 12 | Direct effect of type 1 human immunodeficiency virus (HIV-1) on intestinal epithelial cell differentiation: relationship to HIV-1 enteropathy显示文摘 | Delezay O Yahi N Tamalet C | 1997 | Virology1997，238，2： | 1 |
| 13 | Distribution of human papillomavirus genotypes,assessment of HPV 16and18viral load and anal related lesionsin HIV positive patients:a cross-sectional analysis显示文摘 | Tamalet C Obry-Roguet V Ressiot E | 2014 | J Med Virol2014，86，3： | 1 |
| 14 | Relationship between HPV 16,18,31,35,45 DNA detection and quantitation and E6/E7 mRNA detection among a series of cervical specimens with various degrees of histological lesions 显示文摘 | BARON C HENRY M TAMALET C | 2015 | J Med Virol2015，87，8： | 1 |
| 15 | Evaluation of the clinical performance of the Beckman Coulter Access AbHBsⅡ immunoassay for the detection of hepatitis B surface antibodies显示文摘 | Motte A Colson P Tamalet C | 2006 | J Clin Virol2006，37，3： | 1 |
| 16 | Long term effects of azithromycin in patients with cystic fibrosis,A double blind,placebo controlled trial显示文摘 | Clement A Tamalet A Leroux E | | 0，，10： | 1 |
| 17 | Relationship between HPV 16, 18, 31, 33, 45 DNA detection and quantitation and E6/E7 mRNA detection among a series of cervical specimens with various degrees of histological lesions显示文摘 | Carolina Baron Mireille Henry Catherine Tamalet Julia Villeret Herve Richet Xavier Carcopino | 2015 | J. Med. Virol2015，，8： | 1 |
| 18 | Chronic interstitial lung disease in children:response to high-dose intravenous methylprednisolone pulses显示文摘 | Desmarquest P Tamalet A Fauroux B | 1998 | Pediatr Pulmonol1998，26，5： | 1 |
| 19 | Comparison of two commercial assays for the detection of insertion mutations of HIV-1 reverse transcriptase显示文摘 | Koch N Tamalet C Tivoli N | 2001 | J Clin Virol2001，21，2： | 1 |
| 20 | Chronic interstitial lung disease in children:response to high-dose intravenous methylprednisolone pulses显示文摘 | Desmarquest P Tamalet A Fauroux B | 1998 | Pediatr Pulmonol1998，26，5： | 1 |
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