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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Antiproliferative effect of thalidomide alone and combined with carmusitine against C6 rat glioma显示文摘 | Arrieta O Guevara P Tamarize J | 2002 | Int J Exp Pathol2002，83，2： | 1 |
| 3 | Morphology-based algorithm for point target detection in infrared background显示文摘 | Victor T T Tamar P | 1993 | Proceedings of SPIE1993，1954，： | 1 |
| 4 | A study of edge detection algorithms显示文摘 | Tamar P Davis M | 1982 | CGIP1982，20，： | 1 |
| 5 | 2006 Tobacco free workplace policies and low status female bar tenders in San Francisco 显示文摘 | Roland S Moore Juliet P Lee Tamar M J Antin Scott E Martin | 2006 | J Epidemiol Community Health2006，60，111： | 1 |
| 6 | Programmable and autonomous computing machine made of biomoleccules显示文摘 | BENENSON Y TAMAR P ADAR R | | 0，，22： | 1 |
| 7 | Programmable and autonomous computingmachine made of biomolecules 显示文摘 | Yaakov B Tamar P Rivka A | 2001 | Nature2001，414，22： | 1 |
| 8 | Adaptive filtering for image enhancement显示文摘 | TAMAR P JEE S I | | 0，，01： | 1 |
| 9 | Programmable and autonomous computing machine made of biomoleccules显示文摘 | Benenson Y Tamar P Adar R | 2001 | Nature2001，414，22： | 1 |
| 10 | WONCA研究论文摘要汇编——全科医生在下背痛问诊中的安慰:一项定性研究显示文摘背景在初级医疗中,下背痛管理指南一般推荐医生对患者进行安慰,但是相关阐述不够充分,对患者的作用不明确。目的探讨下背痛患者在问诊中如何感知医生的安慰行为。方法选取23名近期接受全科医生问诊的非特异性下背痛患者。采用半结构采访,探究患者在问诊过程中认为得到安慰的情况和其带来的影响。采用主题框架法,对访谈记录进行分析。结果患者在访谈中回忆问诊经历、信任、期待和希望医生倾听和理解的担忧。在医生给予重视并希望提供帮助的时候,患者感到隐含的安慰;当医患建立关系和医生可以随时帮助患者的时候,患者同样感到隐含的安慰。只有在医生通过解释排除严重疾病直接解除患者担忧、帮助患者理解和应对疼痛的时候,患者才感受到直接的、信息性的安慰。结论本文探讨的隐含与直接安慰分别与情感安慰和认知安慰相对应。虽然研究证实利用信息与教育可以化解患者的担忧,但是通过建立关系和同情心带来的隐含安慰的作用依旧不明确。这些行为对结局的影响应成为未来研究的重点。 | Nicola H Tamar P Steven V 本刊编辑部 | 2015 | 中国全科医学2015，18，32： | 0 |
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