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| 1 | Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions显示文摘Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On' and ‘On to Off' periods using negatively charged particle-dominant indoor air conditions(NCPDIAC).Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON' periods(ON trials) for a total of 16 times,and ‘ON to 3 months OFF'(OFF trials) periods for a total of 13 times.Results With the exception of one case,serum amyloid A(SAA) levels decreased significantly during the ON trials.Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein(CRP),this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events. | Suni Lee Shoko Yamamoto Yasumitsu Nishimura Hidenori Matsuzaki Kei Yoshitome Tamayo Hatayama Miho Ikeda YU Min Nagisa Sada Naoko Kumagai-Takei Takemi Otsuki | 2018 | Biomedical and Environmental Sciences2018，31，5： | 5 |
| 2 | Same-day 2-L PEG-citrate-simethicone plus bisacodyl vs split 4-L PEG: Bowel cleansing for late-morning colonoscopy显示文摘AIM: To evaluate the efficacy, tolerability, acceptability and feasibility of bisacodyl plus low volume polyethyleneglycol-citrate-simeticone(2-L PEG-CS) taken the same day as compared with conventional split-dose 4-L PEG for late morning colonoscopy. METHODS: Randomised, observer-blind, parallel group, comparative trial carried out in 2 centres. Out patients of both sexes, aged between 18 and 85 years, undergoing colonoscopy for diagnostic investigation, colorectal cancer screening or follow-up were eligible. The PEG-CS group received 3 bisacodyl tablets(4 tablets for patients with constipation) at bedtime and 2-L PEG-CS in the morning starting 5 h before colonoscopy. The control group received a conventional 4-L PEG formulation given as split regimen; the morning dose was taken with the same schedule of the low volume preparation. The Ottawa Bowel Preparation Scale(OBPS) score was used as the main outcome measure.RESULTS: A total of 164 subjects were enrolled and 154 completed the study; 78 in the PEG-CS group and 76 in the split 4-L PEG group. The two groups were comparable at baseline. The OBPS score in the PEG-CS group(3.09 ± 2.40) and in the PEG group(2.39 ± 2.55) were equivalent(difference +0.70; 95%CI:-0.09-1.48). This was confirmed by the rate of successful bowel cleansing in the PEG-CS group(89.7%) and in the PEG group(92.1%)(difference-2.4%; 95%CI:-11.406.70). PEG-CS was superior in terms of mucosa visibility compared to PEG(85.7% vs 72.4%, P = 0.042). There were no significant differences in caecum intubation rate, time to reach the caecum and withdrawal time between the two groups. The adenoma detection rate was similar(PEG-CS 43.6% vs PEG 44.7%). No serious adverse events occurred. No difference was found in tolerability of the bowel preparations. Compliance was equal in both groups: more than 90% of subjects drunk the whole solution. Willingness to repeat the same bowel preparations was about 90% for both regimes. CONCLUSION: Same-day PEG-CS is feasible, effective as split-dose 4-L PEG for late morning colonoscopy and does not interfere with work and daily activities the day before colonoscopy. | Annalisa de Leone Darina Tamayo Giancarla Fiori Davide Ravizza Cristina Trovato Giuseppe De Roberto Linda Fazzini Marco Dal Fante Cristiano Crosta | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 5 |
| 3 | Antimicrobial susceptibility testing before first-line treatment for Helicobacter pylori infection in patients with dual or triple antibiotic resistance显示文摘AIM To evaluate the efficacy of antimicrobial susceptibilityguided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance.METHODS A total of 1034 patients infected by Helicobacter pylori(H. pylori) during 2013-2014 were tested for antimicrobial susceptibility. 157 of 1034(15%) patients showed resistance to two(127/1034; 12%) and to three(30/1034; 3%) antibiotics. Sixty-eight patients with dual H. pylori-resistance(clarithromycin, metronidazole or levofloxacin) were treated for 10 d with triple therapies: OAL(omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and levofloxacin 500 mg b.i.d.) 43cases, OAM(omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and metronidazole 500 mg b.i.d.) 12 cases and OAC(omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d.) 13 cases based on the antimicrobial susceptibility testing. Twelve patients showed triple H. pylori-resistance(clarithromycin, metronidazole and levofloxacin) and received for 10 d triple therapy with OAR(omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and rifabutin 150 mg b.i.d.). Eradication was confirmed by 13C-urea breath test. Adverse effects and compliance were assessed by a questionnaire. RESULTS Intention-to-treat eradication rates were: OAL(97.6%), OAM(91.6%), OAC(92.3%) and OAR(58.3%). Cure rate was significantly higher in na?ve patients treated with OAR-10 compared to patients who had two or three previous treatment failures(83% vs 33%). Adverse events rates for OAL, OAM, OAC and OAR were 22%, 25%, 23% and 17%, respectively, all of them mild-moderate. CONCLUSION Antimicrobial susceptibility-guided triple therapies during 10 d for first-line treatment leads to an eradication rate superior to 90% in patients with dual antibiotic H. pylori resistance. | Angel Cosme Milagrosa Montes Begona Ibarra Esther Tamayo Horacio Alonso Usua Mendarte Jacobo Lizasoan Marta Herreros-Villanueva Luis Bujanda | 2017 | World Journal of Gastroenterology2017，23，18： | 4 |
| 4 | Molecular classification of cancer: class discovery and class prediction by gene expression monitoring显示文摘 | Golub T R Slonim D K Tamayo P | | 0，，： | 3 |
| 5 | Study and Characterization of Organically Modified Silica-Zirconia Anti-Graffiti Coatings Obtained by Sol-Gel显示文摘 | M. Rosario Elvira M. Alejandra Mazo Aitana Tamayo Fausto Rubio Juan Rubio Jose Luis Oteo | 2013 | Journal of Chemistry and Chemical Engineering2013，7，2： | 2 |
| 6 | Early experience in human hybrid transgastric and transvaginal endoscopic cholecystectomy显示文摘 | Gustavo Salinas Lil Saavedra Hellen Agurto Rosa Quispe Edwin Ramírez José Grande Juan Tamayo Victoria Sánchez Daniel Málaga Jeffrey M. Marks | 2010 | Surgical Endoscopy2010，，5： | 2 |
| 7 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
| 8 | New charge-carrier blocking materials for high efficiency OLEDs显示文摘 | Vadim I. Adamovich Steven R. Cordero Peter I. Djurovich Arnold Tamayo Mark E. Thompson Brian W. D’Andrade Stephen R. Forrest | 2003 | Organic Electronics2003，，2： | 2 |
| 9 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 10 | Effect of low level laser therapy on dental pulp during orthodontic movement显示文摘AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth obtained from the middle root level were distributed in four groups: group 1(G1) absolute control; group 2(G2) only laser irradiation; group 3(G3) exposed only to orthodontics; and group 4(G4) treated with orthodontics and laser. Laser treatment was performed at 830 nm wavelength, 100 mW(energy 80 J/cm2, 2.2 J), for 22 s in the vestibular surface and 22 s in the palatal surface, 1 mm away from the dental root mucosa. Three staining methods were performed: hematoxylin-eosin(HE), Masson's Trichrome method and Gomori's method.RESULTS: The pulp histology parameters were evaluated and the results classified in to 3 parts: an inflammatory response, soft tissue response(dental pulp) and hard tissue response(dentin and predentin). There was no inflammation(chronic or acute) in any of the evaluated groups. The zones of pulp necrosis were found in one premolar of G3 and in one of G4; in groups G2 and G4 there was higher angiogenesis than in the other two groups. G4 group presented the highest level of vascularization. A reduced nerve density was observed in G3. A G2 specimen showed increased nerve density. A higher rate of calcification was observed in G1 compared to G2. Denticles, either real or false, were observed in G1, G2 and G3. Sclerosis of dentin and focal dentin loss was observed among all the groups. Secondary dentin was present in one sample in G1 and G2. A necrosis zone was found in one sample of G3 and G4. No differences between groups were observed in the odontoblast irregularity layer but the layer was wider in the group treated with laser only. A notable difference was detected in reduction of the cell-free layer between the groups G1 and G4. The findings in pulp tissue favor its adaptative response against dental movement induced by orthodontics. No definitive conclusions may be derived as this is a pilot study. CONCLUSION: The protocol described here was shown to be an effective method to evaluate changes in dental pulp submitted to low level laser in teeth under orthodontic movement. | ngela Domínguez Rosa Emilia Ballesteros Jairo Hernán Viáfara Oscar Mario Tamayo | 2013 | World Journal of Methodology2013，3，2： | 2 |
| 11 | Molecular classification of cancer: class discovery and class prediction by gene expression monitoring 显示文摘 | GOLUB T R SLONIM D K TAMAYO P | 1999 | Science1999，286，： | 2 |
| 12 | Molecular classification of cancer:class discovery and class prediction by gene expression monitoring显示文摘 | Golub T R Slonim D K Tamayo P | 1999 | Science1999，286，： | 1 |
| 13 | Interpreting patterns of gene expression with self-organizing maps:methods and application to hematopoietic显示文摘 | Tamayo P Slonim D Mesirov J | 1999 | Proc Natl Acad Sci USA1999，96，6： | 1 |
| 14 | Using pravastatin to improve the vascular reactivity in a mouse model of soluble Fins-like tyrosine kinase-1 -induced preeclampsia 显示文摘 | Costantine MM Tamayo E Lu F | 2010 | Obstet Gynecol2010，116，1： | 1 |
| 15 | Ventilator-as- sociated pneumonia is an important risk factor for mortality after major cardiac surgery显示文摘 | Tamayo E Alvarez FJ Martinez-Rafael B | 2012 | J Crit Care2012，27，1： | 1 |
| 16 | Molecularclassification of cancer : class discovery and class predic-tion by gene expression monitoring 显示文摘 | Golub T R Slonim D K Tamayo P | 1999 | Science1999，286，： | 1 |
| 17 | Synthesis and Characterization of Facial and Meridional Tris-Cyclometalated Iridium(Ⅲ) Complexes显示文摘 | Tamayo A B Alleyne B D Djurovich P I | 2003 | J Am Chem Soc2003，125，24： | 1 |
| 18 | Molecular classification of cancer: class discovery and class prediction by gene expression monitoring显示文摘 | GOLUB T R SLONIM DK TAMAYO P | 1999 | Science1999，286，5439： | 1 |
| 19 | The lack of a functional p21(WAF1/CIP1)gene ameliorates progression to chronic renal failure显示文摘 | Megyesi J Price PM Tamayo E | | 0，，： | 1 |
| 20 | Interpreting patterns of gene expression with salf-organizing maps显示文摘 | P Tamayo | 1999 | In proceedings of National Academy of Science1999，96，6： | 1 |
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