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| 1 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 2 | Relief of vasomotor symptoms and vaginal atrophy with three doses of conjugated estrogens and medroxyprogesterone acetate in postmenopasal Asian women from 11 countries: The Pan-Asia menopause(PAM) study 显示文摘 | Tan D Haines CJ Limpaphayom KK | 2005 | Maturitas2005，52，1： | 1 |
| 3 | Immunogenicity of recombinant yeast-derived hepatitis B vaccine in non-responders to perinatal immunization显示文摘 | Goh KT Oon CJ | 1994 | JAMA1994，271，11： | 1 |
| 4 | A randomized controlled comparison of upper-extremity rehaFugl Meyerlitation strategies in acute stroke: a pilot study of immediate and long-term outcomes显示文摘 | Winstein CJ Rose DK Tan SM | 2004 | Arch Phys Med RehaFugl-Meyerl2004，85，： | 1 |
| 5 | Diagnostic mana- gementof clinically suspected acute deep vein thrombosis显示文摘 | Tan M Van Rooden CJ Westerbeek RE | 2009 | Br J Haematol2009，146，4： | 1 |
| 6 | Clinical spectrum ofvoltage-gated potassium channel autoimmunity显示文摘 | Tan KM Lennon VA Klein CJ | 2008 | Neurolo-gy2008，70，： | 1 |
| 7 | A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: a pilot study of immediate and long-term outcomes显示文摘 | Winstein CJ Rose DK Tan SM | 2004 | Arch Phys Med Rehabil2004，85，： | 1 |
| 8 | Involvement of nuclear factor kappa B in the regulation of cyclocxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes显示文摘 | Crofford LJ Tan B McCarthy CJ | 1997 | Arthritis Rheum1997，40，2： | 1 |
| 9 | Congenital auricular anomalies:topographic anatomy,embryology,classification,and treatment strategies显示文摘 | Porter CJ Tan ST | 2005 | Plast Reconstr Surg2005，115，6： | 1 |
| 10 | Viral hepatocarcinogenesis: from infection to cancer显示文摘 | Tan A Yet SH Liu CJ | 2008 | Liver Int2008，28，： | 1 |
| 11 | Inactivation of glycogen synthase kinase- 3beta contributes to brain derived neutrophic factor/TrkB-induced resistance to chemotherapy in neuroblastoma cells 显示文摘 | Li Z Tan F Thiele CJ | 2007 | Mol Cancer Ther2007，6，121： | 1 |
| 12 | Potentiation of noise-induced hearing loss by amikacin in guinea pigs显示文摘 | Tan CT Hsu CJ Lee SH | 2001 | Hear Res2001，161，： | 1 |
| 13 | Relief of vasomotor symptoms and vaginal atrophy with three doses of conjugated estrogens and medroxyprogesterone acetate in postmenopasal Asian women from 11 countries:The Pan-Asia menopause(PAM) study显示文摘 | Tan D Haines CJ Limpaphayom KK | 2005 | Maturitas2005，52，1： | 1 |
| 14 | Diagnostic management of clinically suspected acute deep vein thrombosis显示文摘 | Tan M Rooden CJ Westerbeek RE | | 0，，02： | 1 |
| 15 | Defi-ning the interactions between proteins and surfactants fornanoparticle surface imprinting through miniemulsion poly-merization显示文摘 | TAN CJ WANGRANGSIMAKUL S BAI R B | 2008 | Chemi Mater2008，20，1： | 1 |
| 16 | A randomized controlled comparison of upper-extremity rehafug-lMeyerlitation strategies in acute stroke:a pilot study of immediate and long-term outcomes显示文摘 | Winstein CJ Rose DK Tan SM | 2004 | Arch Phys Med Rehabil2004，85，4： | 1 |
| 17 | Surgical versus endoscopic treatment of bile duct stones显示文摘 | Dasari BV Tan CJ Gurusamy KS | 2013 | Cochrane Database Syst Rev2013，，00： | 1 |
| 18 | A randomized controlled comparison of upper extremity rehabilitation strategies in acute stroke:A pilot study of immediate and longterm outcomes显示文摘 | Winstein CJ Rose DK Tan SM | 2004 | Arch Phys Med Rehabil2004，85，4： | 1 |
| 19 | Sp1 is a critical factor for the monocytic specific expression of human CD14显示文摘 | Hetherington CJ TanS etal | 1994 | J Biol Chem1994，269，11： | 1 |
| 20 | Breastfeeding and asthma and allergies:a systematic review and meta-analysis显示文摘 | Lodge CJ Tan DJ Lau M | 2015 | Acta Paediatr2015，104，467： | 1 |
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