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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 3 | 人工全膝关节置换术后单纯金属底座髌骨假体的翻修显示文摘目的分析带金属底座髌骨假体失败的原因,并观察单纯髌骨假体翻修的临床疗效。方法对 22例 (30膝 )人工全膝关节置换术后因金属底座髌骨假体失败而行单纯髌骨假体翻修者进行回顾性分析。假体均为同一类型的后十字韧带保留型假体,以金属底座髌骨假体置换髌骨。应用膝关节 KSS评分标准评价翻修术后的临床转归。结果髌骨假体失败时间在人工全膝关节置换术后的 26~ 96个月,平均 62.3个月,主要症状有金属摩擦感 (80% )和膝关节疼痛 (70% )。术中发现 23膝 (76.7% )聚乙烯完全磨损、金属底座外露; 9膝髌骨倾斜或半脱位; 2膝完全脱位。 30膝均成功施行骨水泥全聚乙烯髌骨翻修术,随访时间 24~ 81个月,平均 42.5个月。所有患者主诉症状消失,可独立行走活动,膝关节评分从术前的平均 73分( 27~ 88分)增加至 87分( 60~ 100分);膝关节屈曲度由术前的平均 91°增加至 99.5°。结论 (1)金属底座髌骨假体早期失败率较高; (2)髌骨位线不良和异常滑动轨迹是导致带金属底座髌骨假体失败的诱发因素; (3)单纯髌骨假体翻修可获满意的临床结果,其发生并发症的潜在危险和人工全膝关节翻修术相似,应予以重视。 | 张先龙 SJ Yue NN Lo KH Seow SK Tan | 2001 | 中华骨科杂志2001，21，1： | 2 |
| 4 | Characterization of interleukin-10 receptors on human and mouse cells显示文摘 | Tan JCS Indelicato SK Narula PJ | 1993 | J Biol Chem1993，268，21： | 1 |
| 5 | Female ageing and reproductive outcome in assisted reproduction cycles显示文摘 | Tan TY Lau SK Loh SF | 2014 | Singapore Med2014，55，6： | 1 |
| 6 | Serotonin-dependent depression in Parkinson's disease :a role for the subthalamic nucleus? 显示文摘 | Tan SK Hartung H Sharp T | 2011 | Neurophar- macology2011，61，3： | 1 |
| 7 | Intramural gallbladder hematoma mimicking gallbladder neoplasm in a 33-year-old male 显示文摘 | Tan SW Lai SK Ng KW | 2005 | J Chin Med Assoc2005，68，3： | 1 |
| 8 | Biomarkers in cardiorenal syndromes 显示文摘 | Tan K Sethi SK | 2014 | Transl Res2014，164，2： | 1 |
| 9 | Benificial effects of lamividine in hepatitis B virus related decompensated cirrhosis 显示文摘 | Sarin SK Kapoor DK Gup tan RC | 1999 | Hepatolog)1999，30，42： | 1 |
| 10 | Biomarkers in cardiorenal syndromes 显示文摘 | Tan K Sethi SK | 2014 | Transl Res2014，164，2： | 1 |
| 11 | Comparison of the Elec-sys PTH(l-84) assay with four contemporary second gen-eration intact PTH assays and association with otherbiomarkers in chronic kidney disease patients显示文摘 | Tan K Ong L Sethi SK | 2013 | ClinBiochem2013，46，9： | 1 |
| 12 | Outcome of early cervical carcinoma treated by Wertheim hysterectomy with selective postoperative radiotherapy 显示文摘 | Tay SK Tan LK | 1998 | Ann Acad Med Singapore1998，27，5： | 1 |
| 13 | Obturator hernia:diagnosis and treatment in the modern era显示文摘 | Mantoo SK Mak K Tan TJ | | 0，，09： | 1 |
| 14 | Surgical mamagement of angiomyolipoma显示文摘 | Yip SK Tan PH Cheng WS | 2000 | Scand J Urol Nephrol2000，34，1： | 1 |
| 15 | MAP- 1 is a mitochondrial effector of Bax显示文摘 | Tan KO Fu NY Sukumaran SK | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 16 | High mortality in Nipah encephalitis is associated with presence of virus in cerebrospinal fluid 显示文摘 | Lam SK Tan CT | 2000 | Ann Nenal2000，48，5： | 1 |
| 17 | Treatment of infantile hemangiomas withthe 595-nm pulsed dye laser using different pulse widths inan Asian population显示文摘 | Tay YK Tan SK | 2012 | Lasers Surg Med2012，44，2： | 1 |
| 18 | Sustaining teacher change through participating in a comprehensive approach to teaching Chinese lit- eracy显示文摘 | Tse SK Ip Okm Tan WX | 2012 | Teacher Development2012，16，3： | 1 |
| 19 | Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians 显示文摘 | Tan CE Chew SK Ma S | 2004 | Diabetes Care2004，27，： | 1 |
| 20 | Increased alpha-B-erystallin ex- pression in mammary metaplastic carcinomas 显示文摘 | Chan SK Lui PC Tan PH | 2011 | Histopathology2011，59，2： | 1 |
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