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| 1 | Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells显示文摘Allergic asthma that is caused by inhalation of house dust mites(HDMs)is mainly mediated by Th2 cells.Recently,the roles of Sox(SRY-related high-mobility-group(HMG)-box)family members in various immune responses have been investigated.However,the roles of Sox12,a member of the SoxC group,in Th2 cell differentiation and allergic airway inflammation,remain unknown.We showed that Sox12 mRNA was significantly increased during Th2 cell differentiation.In vivo,HDM-induced eosinophil infiltration into the lung and Th2 cell differentiation were exacerbated in Sox12−/−mice compared with those in control Sox12+/−mice.In vitro,Sox12−/−CD4^(+)T cells that were cultured under Th2 conditions had increased production of Th2 cytokines and GATA3 protein compared with those of control Sox12+/−CD4^(+)T cells.Importantly,forced expression of Sox12 decreased the protein levels of GATA3 in CD4^(+)T cells under Th2 conditions without affecting mRNA expression.Furthermore,Sox12 induced degradation of GATA3 through the proteasome pathway in CD4^(+)T cells.Consistently,Sox12 enhanced ubiquitination of GATA3,which was mediated by the E3 ligase Fbw7.Finally,we found that Fbw7 knockdown partly abrogated Sox12-mediated GATA3 suppression in CD4^(+)T cells.Taken together,these results suggest that Sox12 suppresses Th2 cell differentiation by accelerating Fbw7-mediated GATA3 degradation,and attenuates HDM-induced allergic inflammation. | Ken-Ichi Suehiro Akira Suto Kensuke Suga Hiroki Furuya Arifumi Iwata Taro Iwamoto Shigeru Tanaka Takahiro Kageyama Kotaro Suzuki Koichi Hirose Véronique Lefebvre Hiroshi Nakajima | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 2 | Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light显示文摘 | TANAKA E CHOI H S HUMBLET V | 2008 | Surgery2008，144，1： | 1 |
| 3 | Failure of imiquimod 5% cream to prevent recurrence of surgically excised trunk keloids显示文摘 | Cacao FM Tanaka V Messina MC | 2009 | Dermatol Surg2009，35，4： | 1 |
| 4 | Effect of crystalllnity of TiO2 on its photocatalytic action 显示文摘 | Tanaka K Capule M F V Hisanag T | 1991 | Chem Plays Lett1991，187，12： | 1 |
| 5 | International consensus guidelines 2012 for management of IPMN and MCN of the pancreas显示文摘 | Tanaka M Ferndndez-del Castillo C Adsay V | 2012 | Pancreatology2012，12，3： | 1 |
| 6 | Effect of interface on the thermal conductivity of carbon nanotube composites显示文摘 | SINGH I V TANAKA M ENDO M | 2007 | Int J Thermal Sci2007，46，9： | 1 |
| 7 | p73 induction after DNA damage is regulated by checkpoint kina- ses Chkl and chk2 显示文摘 | Marshall Ufist Tomoaki Tanaka Masha V Poyurovsky | 2004 | Genes and Develop2004，18，24： | 1 |
| 8 | Fractal properties of medium and seism electric phenomena显示文摘 | SURKOV V V UYEDA S TANAKA H | 2002 | Journal of Geodynamics2002，33，45： | 1 |
| 9 | Optimal transformations of the integration variables in computation of singular integrals in BEM 显示文摘 | Sladek V Sladek J Tanaka M | 2000 | Int J Numer Meth Engng2000，47，： | 1 |
| 10 | International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas 显示文摘 | Tanaka M Chaff S Adsay V | 2006 | Pancreatology2006，6，12： | 1 |
| 11 | International consensus guidelines 2012 for management of IPMN and MCN of the pancreas显示文摘 | Tanaka M Ferndndez-del Castillo C Adsay V | 2012 | Pancreatology2012，12，3： | 1 |
| 12 | Angiotensin con- verting enzyme inhibitor modulates glomerular function and structure by discinct mechanisms 显示文摘 | Tanaka R Kon V Yoshioka T | 1994 | Kidney Int1994，45，2： | 1 |
| 13 | Boundary element solution of some structure-acoustic coupling problems using the Multiple Reciprocity Method显示文摘 | Sladek V Sladek J Tanaka M | 1994 | Comm Numer Method Eng1994，10，2： | 1 |
| 14 | Regularization techniques applied to boundary element methods显示文摘 | Tanaka M Sladek V Sladek J | 1994 | Appl Mech Rev1994，47，10： | 1 |
| 15 | Laser- assisted blastocyst dissection and subsequent cultivation of embryonic stem cells in a serum/cell free culture system: applications and preliminary results in a murine model 显示文摘 | Noriko Tanaka Takumi Takeuchi Queenie V Neri | 2006 | Journal of Translational Medicine2006，4，： | 1 |
| 16 | Controlling the weight loss of fresh produce during postharvest storage under a nano-size mist environment显示文摘 | Hung D V Tong S Tanaka F | 2011 | J Food Eng2011，106，4： | 1 |
| 17 | Internatio- nal consensus guidelines 2012 for the management of IPMN and MCN of the pancreas 显示文摘 | Tanaka M Ferndndez-del Castillo C Adsay V ct al | 2012 | Pancreatology2012，12，3： | 1 |
| 18 | Method for assessing the similarity between subsets of the T cell receptor repertoire显示文摘 | Venturi V Kedzierska K Tanaka MM | 2008 | J Immunol Methods2008，269，12： | 1 |
| 19 | Multiple Reciprocity Method for harmonic vibration of thin elastic plates显示文摘 | Sladek V Sladek J Tanaka M | 1993 | Applied Mathematics and Model1993，17，4： | 1 |
| 20 | The neural corre- lates of memory encoding andrecognition for own - race and other -race faces 显示文摘 | Herzmann G Willenboekcl V Tanaka J W | 2011 | Neuropsychologia2011，49，： | 1 |
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