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| 1 | 症状性脑内动脉粥样硬化性血栓形成性狭窄的前瞻性研究:GESICA研究显示文摘Background: Symptomatic intracranial atherothrombotic stenoses (ICAS) are associated with high rates of cerebrovascular ischemic events. Objective: To conduct a prospective multicenter study to evaluate the natural history of ICAS and, in those patients refractory to medical treatment, the outcomes associated with intracranial angioplasty. Methods: Patients aged 18 to 80 were enrolled with symptoms attributed to a single ICAS of ≥50%. Optimal medical therapy of vascular risk factors and preventive antithrombotic therapy were at the discretion of the local investigator. Patients were eligible for intracranial angioplasty after experiencing recurrent stroke despite medical therapy. Neurologic and ultrasonographic examinations were performed at study inclusion, 3 months after enrollment, and every 6 months of follow-up thereafter, for 36 months. Results:One hundred two patients were included, with a mean age of 63.3 ±10.4 years. Intracranial artery stenoses involved the vertebral artery in 22.5%, the basilar artery in 25.5%, the middle cerebral artery in 26.5%, and the internal carotid artery in 25.5%. In 27.4%of the patients, the stenoses had clinical hemodynamic characteristics. During a mean follow-up of 23.4 months, 38.2%of the patients had a cerebrovascular event: ischemic stroke in 13.7%and TIA in 24.5%. Among patients with a hemodynamically significant stenosis, 60.7%had a recurrent stroke or TIA in the territory of the stenotic artery; this association was significant in univariate analysis.Twenty-eight patients underwent an endovascular procedure with a neurologic periprocedural complication rate of 14.2%.The overall vascular death rate was 8.8%. Conclusions: Despite medical treatment, the 2-year recurrence rate of ischemic events in the territory of the stenotic artery was 38.2%. Cardiovascular events occurred in 18.6%of patients. Clinically significant hemodynamic stenoses were associated with stroke recurrence and may help identify a high risk subset of patients. | Mazighi M. Tanasescu R. Ducrocq X. 樊慧婷(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 6 |
| 2 | Prospective study of symptomatic atherothrombotic intracranial stenoses: The GESICA Study显示文摘 | M Mazighi R Tanasescu X Ducrocq E Vicaut S Bracard E Houdart F Woimant | 2006 | Neurology2006，，8： | 2 |
| 3 | Fever of unknown origin- predictors of outcome a prospective muhicenter study on 164 patients 显示文摘 | Baicus C Bolosiu HD Tanasescu C | 2003 | Eur J Intern Med2003，14，4： | 1 |
| 4 | Eczema-like cutaneous graft versus host disease treated by UV-B therapy in a 2-year-old child显示文摘 | Tanasescu S Balguerie X Thomine E | | 0，，01： | 1 |
| 5 | Exercise type and intensity in relation to coronary heart disease in men显示文摘 | Tanasescu M Leitzmann M F Rimm E B | 2002 | JAMA2002，288，16： | 1 |
| 6 | Appartent worsening of thallium-201 myocardial defects during redistribution-what does it mean显示文摘 | Tanasescu DE Berman DS Staniloff H | 1979 | J Nucl Med1979，20，： | 1 |
| 7 | Fever of unknown origin-predictors of outcome A prospective multicenter study on 164patients显示文摘 | Baicus C Bolosiu HD Tanasescu C | 2003 | Eur J Int Med2003，14，4： | 1 |
| 8 | Quantitative fluorescence in situ Hybridization and its ability to predict bladder cancer recurrence and progression to musele-inva-sive cancer 显示文摘 | Kipp B R Tanasescu M Else T A | 2009 | J MolDiagn2009，11，2： | 1 |
| 9 | Prospective study of symptomatic atherothrombotic intracranial stenosis: the GESICA study显示文摘 | Mazighi M Tanasescu R Ducrocq X | 2006 | Neurology2006，66，8： | 1 |
| 10 | I Anticardiolipin antibodies,recurrent stroke and vascular events:a prospective study on 210 patients显示文摘 | Tanasescu R Ticmeanu M Nicolau A | 2005 | Romanian Journal of Internal Medicine2005，43，12： | 1 |
| 11 | Expression of IL-6 activity in patients with acute ischemic stroke显示文摘 | Cojocaru IM Cojocaru M Tanasescu R | 2009 | Rom J intern Med2009，47，： | 1 |
| 12 | Dietary fat and cholesterol and the risk of cardiovascular disease among women with type 2 diabetes 显示文摘 | Tanasescu M Cho E Manson JE | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 13 | Prospective study of symptomatic atherothrombotic intracranial ste- noses : the GESICA study 显示文摘 | Mazighi M Tanasescu R Ducrocq X | 2006 | Neurology2006，66，8： | 1 |
| 14 | Dietary fat and cholesterol and the risk of cardiovascular disease among women with type 2 diabetes显示文摘 | Tanasescu M Cho E Manson JE | 2004 | Am J Clin Nutr2004，79，6： | 1 |
| 15 | Prospective study of symptomatic atherothrombotic intracranial stenoses:the GESICA study显示文摘 | Mazighi M Tanasescu R Ducrocp X | 2006 | Neurology2006，66，8： | 1 |
| 16 | A new definedentity among the spectrum of central nervous system inflam-mation; chronic lymphocytic inflammation with pontineperivascular enhancement responsive to steroids (CLIP-PERS) 显示文摘 | Jerca 0 Manouchehrinia A Tanasescu R | 2011 | Rom J Neurol Psychiatry2011，5，2： | 1 |
| 17 | Kikuchi's disease associated with systemic lupus erythematosus and autoimmune-like hepatitis显示文摘 | Tanasescu C Nitescu D Staniceanu F | 2003 | Rom J Intern Med2003，41，3： | 1 |
| 18 | Quantitative Fluo- rescence in Situ Hybridization and its Ability to Predict Blad- der Cancer Recurrence and Progression to Muscle- Invasive Bladder Cancer显示文摘 | Kipp B R Tanasescu M Else T A | 2009 | J Mol Diagn2009，11，2： | 1 |
| 19 | Prospective study of symptomatic atheroothrombotic intracranial stenosis: the GESICA study 显示文摘 | Mazighi M Tanasescu R Ducrocq X | 2006 | Neurology2006，66，8： | 1 |
| 20 | Exercise type and intensity in relation to coronary heart disease in men显示文摘 | Tanasescu M Leitzmann M F Rimm E B | 2002 | JAMA2002，288，16： | 1 |
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