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| 1 | Liver transplantation: Current status and challenges显示文摘Great progress has been made in the field of liver transplantation over the past two decades. This progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. This effort has resulted in a greater use of liver allografts following donation after cardiac death(DCD) along with marginal and extended criteria donors. Improved understanding of the pathophysiology of liver allografts procured after circulatory arrest has not only resulted in better selection and management of DCD donors, but has also helped in the development of mechanical perfusion strategies. Early outcomes demonstrating the clinical applicability of both hypothermic and normothermic perfusion and its potential to impact patient survival and allograft function have generated much interest. Second, long-term outcomes of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as infection, malignancy and renal failure. Furthermore, recent evidence suggests that chronic immune-mediated injury to the liver may also impact graft function. | Caroline C Jadlowiec Timucin Taner | 2016 | World Journal of Gastroenterology2016，22，18： | 23 |
| 2 | Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C显示文摘Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre-and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications. | Lena Sibulesky Justin H Nguyen Ricardo Paz-Fumagalli C Burcin Taner Rolland C Dickson | 2009 | World Journal of Gastroenterology2009，15，40： | 5 |
| 3 | Revisiting the liver’s role in transplant alloimmunity显示文摘The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation.This phenomenon was observed nearly five decades ago.Subsequently,the liver’s role in multivisceral transplantation was recognized,as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart.The liver has a unique architecture and is home to many cells involved in immunity and inflammation.After transplantation,these cells migrate from the liver into the recipient.Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system.Recent studies on human T-cell subtypes,cytokine expression,and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation.In this article,we discuss the privileged state of liver transplantation compared to other solid organ transplantation,the liver allograft’s role in multivisceral transplantation,various cells in the liver involved in immune responses,and the potential mechanisms underlying immunomodulation of host alloresponses. | Nitin Abrol Caroline C Jadlowiec Timucin Taner | 2019 | World Journal of Gastroenterology2019，25，25： | 2 |
| 4 | Is increased ma ternal endothelin-1 concentration associated with neonatal as- phyxia and pretern delevery in intrahepatic cholestasis of preg nancy显示文摘 | Kebapcilar A G Kehapcilar L Taner C E | 2010 | Arch Gynecol Obstet2010，282，6： | 1 |
| 5 | Detection of human papillomavirus DNA and genotyping in patients with epithelial ovarian carcinoma显示文摘 | Atalay F Taskiran C Taner MZ | 2007 | Obstet Gynaecol Res2007，33，6： | 1 |
| 6 | Fetal abdominal wall defects:Six years experience at a tertiary center显示文摘 | Ekin A Gezer C Taner CE | 2015 | Clin Exp Obstet Gynecol2015，42，3： | 1 |
| 7 | 5-Fluorouracil as chemoadjuvant for primary pterygium surgery:preliminary report显示文摘 | Akarsu C Taner P Ergin A | 2003 | Cornea2003，22，6： | 1 |
| 8 | Surgicaltreatment of gallbladder cancer 显示文摘 | TANER C B NAGORNEY D M DONOHUE J H | 2004 | J Gastrointest Surg2004，8，1： | 1 |
| 9 | Synthesis and anticonvulsant activity of some (2/4-substituted) Benzaldehyde(2-oxobenzothiazolin-3-yl)acetohydrazones显示文摘 | Bilge C Engin Y Taner E | 1999 | Ⅱ Farmaco1999，54，： | 1 |
| 10 | A new investigation with the salting-out effect on emulsifier-free emulsion polymerization of methyl methacrylate显示文摘 | Seda C Taner T | 2007 | Journal of Applied Polymer Science2007，103，4： | 1 |
| 11 | Outcomes following liver transplantation in intensive care unit patients显示文摘AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient survival.METHODS:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December 2010.RESULTS:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and norepinephrine.Sixteen ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to transplantation.Twenty-five ICU patients (64%) required dialysis preoperatively.At 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU patients.Patient survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU patients.When formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable analysis.These findings were consistent in multivariable analysis.Although not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (RR:4.19,P=0.033).Graft survival and patient survival were not significantly worse for patients on mechanical ventilation (RR:0.91,P=0.88 in graft loss;RR:0.69,P=0.56 in death) or patients on vasopressors (RR:1.06,P=0.93 in graft loss;RR:1.24,P=0.74 in death) immediately prior to LT.Trends toward lower graft survival and patient survival were observed for patients on dialysis immediately before LT,however these findings did not approach statistical significance (RR:1.70,P=0.43 in graft loss;RR:1.46,P=0.58 in death).CONCLUSION:Although ICU patients when compared to non-ICU patients have lower survivals,outcomes are still acceptable.Pre-transplant ventilation,hemodialysis,and vasopressors were not associated with adverse outcomes. | Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen | 2013 | World Journal of Hepatology2013，5，1： | 1 |
| 12 | Chromosomal and structural anomalies in fetuses with open neural tube defects显示文摘 | Ekin A Gezer C Taner CE | 2014 | J Obstet Gynaecol2014，34，2： | 1 |
| 13 | relationships and heritability estimates of traits in lobolly pine(P/nus taede) 显示文摘 | LOO J A TANER C G Van BUIJTEN J P | 1984 | Can J For Res1984，14，： | 1 |
| 14 | Surgical Treatment of Gallbladder Cancer 显示文摘 | BURCIN TANER C DAVID M M D NAGORNEY | 2004 | Journal of Gastrointestinal Surgery2004，8，1： | 1 |
| 15 | Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism显示文摘 | Taner C Inal M Basogul O | 2002 | Gynecol Obstet Invest2002，54，2： | 1 |
| 16 | Risk factors and perinatal outcomes associated with latency in preterm premature rupture of membranes between 24 and 34 weeks of gestation显示文摘 | Ekin A Gezer C Taner CE | 2014 | Arch Gynecol Obstet2014，290，3： | 1 |
| 17 | Vasopressin compared to dopamine and norepinephrine as first-line vasopressor for septic shock 显示文摘 | Hall L G Oyen L J Taner C B | 2001 | Crit Care Med2001，，： | 1 |
| 18 | Cutting edge: sanglifehrin A, a novel cyclophilin - binding immunosup- pressant blocks bioactive IL- 12 production by human dendritic ceils 显示文摘 | Steinschulte C Taner T Thomson AW | 2003 | J Immunol2003，171，2： | 1 |
| 19 | Risk factors and perinatal outcomes associated with latency in preterm premature rupture of membranes between 24 and 34 weeks of gestation显示文摘 | Ekin A Gezer C Taner CE | 2014 | Arch Gynecol Obstet2014，290，3： | 1 |
| 20 | The effect of EDTA,EGTA,EDTAC,and tetracycline-HCI with and without sub-sequent NaOCl treatment on themicrohardness of root canal dentin显示文摘 | Taner Cem Sayin Ahmet Serper Zafer C | 2007 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007，104，： | 1 |
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