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| 1 | Prehypertension: Underlying pathology and therapeutic options显示文摘Prehypertension(PHTN) is a global major health risk that subjects individuals to double the risk of cardiovascular disease(CVD) independent of progression to overt hypertension. Its prevalence rate varies considerably from country to country ranging between 21.9% and 52%. Many hypotheses are proposed to explain the underlying pathophysiology of PHTN. The most notable of these implicate the renin-angiotensin system(RAS) and vascular endothelium. However, other processes that involve reactive oxygen species, the inflammatory cytokines, prostglandins and C-reactive protein as well as the autonomic and central nervous systems are also suggested. Drugs affecting RAS have been shown to produce beneficial effects in prehypertensives though such was not unequivocal. On the other hand, drugs such as β-adrenoceptor blocking agents were not shown to be useful. Leading clinical guidelines suggest using dietary and lifestyle modifications as a first line interventional strategy to curb the progress of PHTN; however, other clinically respected views call for using drugs. This review provides an overview of the poten-tial pathophysiological processes associated with PHTN, abridges current intervention strategies and suggests investigating the value of using the 'Polypill' in prehypertensive subjects to ascertain its potential in delaying(or preventing) CVD associated with raised blood pressure in the presence of other risk factors. | Sulayma Albarwani Sultan Al-Siyabi Musbah O Tanira | 2014 | World Journal of Cardiology2014，6，8： | 13 |
| 2 | NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations显示文摘AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic signifi cance of NAT2.METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses.RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic signifi cance.CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic signif icance. | Mansour S Al-Moundhri Mohamed Al-Kindi Maryam Al-Nabhani Bassim Al-Bahrani Ikram A Burney Ali Al-Madhani Shyam S Ganguly Misbah Tanira | 2007 | World Journal of Gastroenterology2007，13，19： | 5 |
| 3 | Genetic variations related to hypertension: A review显示文摘 | Tanira MO KA A1 Balushi | 2005 | J Hum Hypertens2005，19，1： | 1 |
| 4 | Some phytochem- ical, pharmacological and toxicological properties of ginger (Zingiberofficinale roscoe): a review of recent research 显示文摘 | Ali B H Blunden G Tanira M O | 2008 | Food and Chemical Toxicology2008，46，2： | 1 |
| 5 | Genetic variations related to hypertension : a review显示文摘 | Tanira MO Al BKA | 2005 | J Hum Hypertens2005，19，1： | 1 |
| 6 | Some phytochemical, pharmacological and toxicological properties of ginger ( Zingiber officinale Roscoe): A review of recent research显示文摘 | Badreldin H. Ali Gerald Blunden Musbah O. Tanira Abderrahim Nemmar | 2007 | Food and Chemical Toxicology2007，，： | 1 |
| 7 | Some phytochemical,pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe) : a review of recent research 显示文摘 | All B H Blunden G Tanira M O | 2008 | Food and Chemical Toxicology2008，46，2： | 1 |
| 8 | Genetic variations related to hypertension:A review显示文摘 | Tanira MO A1 Balushi KA | 2005 | J Hum Hypertens2005，19，： | 1 |
| 9 | Genetic variations related to hypertension: a review显示文摘 | TANIRA M O AL BALUSHI K A | 2005 | J Hum Hypertens2005，19，1： | 1 |
| 10 | Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research 显示文摘 | Ali BH Blunden G Tanira MO | 2008 | Food Chem Toxieol2008，46，2： | 1 |
| 11 | Some phytochemical,pharmacological and toxicological properties of ginger(Zingiber officinale Roscoe):areview of recent research显示文摘 | Ali BH Blunden G Tanira MO | 2008 | Food Ghem Toxicol2008，46，2： | 1 |
| 12 | Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe) : a review of recent research显示文摘 | Ali BH Blunden G Tanira MO | 2008 | Food Chem Toxicol2008，46，2： | 1 |
| 13 | Effect of endotoxin on gentamicin pharmacokinetics in old and young adult rats显示文摘 | Tanira Mort Ali BH Bashir AK | 1997 | Life Sci1997，60，6： | 1 |
| 14 | Genetic variations related t o hypertension : a review显示文摘 | Tanira M Balushi K | 2005 | J Hum Hypertens2005，19，： | 1 |
| 15 | Genetic variations related to hypertension:a review显示文摘 | Tanira MO Al Balushi KA | 2005 | J Hum Hypartens2005，19，1： | 1 |
| 16 | Genetic variations related to hypertension : a review显示文摘 | Tanira MO A1 Balushi KA | 2005 | J Hum Hypertens2005，19，： | 1 |
| 17 | Some phytochemical,pharmacological and toxicological properties of ginger(Zingiber officinale Roscoe):A review of recent research显示文摘 | Ali B H Blunden G Tanira M O | 2008 | Food Chem Toxicol2008，46，2： | 1 |
| 18 | Some phytochemical,pharmacological and toxicological properties of ginger(Zingiber officinale Roscoe):a review of recent research显示文摘 | ALI B H BLUNDEN G TANIRA M O | 2008 | Food and Chemical Toxicology2008，46，2： | 1 |
| 19 | Some phytochem-ical,pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe):a review of recent research显示文摘 | Ali BH Blunden G Tanira MO | 2008 | Food Chem Toxicol2008，46，2： | 1 |
| 20 | Genetic variations related to hypertension: A review 显示文摘 | Tanira M Balushi KA | 2005 | J Hum Hypertens2005，19，： | 1 |
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