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| 1 | Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection显示文摘AIM: To analyze the time interval ('delay') between the first occurrence of clinical parameters associated with anastomotic leakage after colorectal resection and subsequent relaparotomy. METHODS: In 36 out of 289 consecutive patients with colorectal anastomosis, leakage was confirmed at relaparotomy. The medical records of these patients were retrospectively analysed and type and time of appearance of clinical parameters suggestive of anastomotic leakage were recorded. These parameters included heart rate, body temperature, local or generalized peritoneal reaction, leucocytosis, ileus and delayed gastric emptying. Factors influencing delay of relaparotomy and consequences of delayed recognition and treatment were determined. RESULTS: First documentation of at least one of the predefined parameters for anastomotic leakage was after a median interval of 4 ± 1.7 d after the operation. The median number of days between first parameter(s) associated with leakage and relaparotomy was 3.5 ± 5.7 d. The time interval between the first signs of leakage and relaparotomy was significantly longer when a weekend was included (4.2 d vs 2.4 d, P = 0.021) or radiological evaluation proved to be false-negative (8.1 d vs 3.5 d, P = 0.007). No significant association between delay and number of additional relaparotomies, hospital stay or mortality could be demonstrated. CONCLUSION: An intervening weekend and negative diagnostic imaging reports may contribute to a delay in diagnosis and relaparotomy for anastomotic leakage. That delay was more than two days in two-thirds of the patients. | A Doeksen PJ Tanis BC Vrouenraets JJB Lanschot van WF Tets van | 2007 | World Journal of Gastroenterology2007，13，27： | 17 |
| 2 | Chemokines and chemokine receptors in inflammatory demyelinating neuropathies显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，4： | 1 |
| 3 | Venous and arterial thrombosis during oral contraceptive use: risks and risk factors 显示文摘 | Tanis BC Rosendaal FR | 2003 | Serain Vasc Med2003，3，1： | 1 |
| 4 | Chemokines and chemokine receptors inflammatory demyelinating neuropathies:a central role for IP-10显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，4： | 1 |
| 5 | Chlamydia pneu moniae, Helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women 显示文摘 | Bloemenkamp DG Mali WP Tanis BC | 2002 | Atherosclerosis2002，163，1： | 1 |
| 6 | Chemokines and chemokine receptors in inflammatory demyelinating neuropathies:a central role for 1P-10显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，4： | 1 |
| 7 | Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women 显示文摘 | Bloemenkamp DG Mall WP Tanis BC | 2002 | Atherosclerosis2002，163，1： | 1 |
| 8 | Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies显示文摘 | Tanis BC Westendorp GJ Smelt HM | 1996 | Clin Endocrinol1996，44，： | 1 |
| 9 | Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10 显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，： | 1 |
| 10 | Risk of arterial thrombosis in relation to oral contraceptives(RATIO)study:Oral contraceptives and the risk of ischemic stroke显示文摘 | Kemmeren JM Tanis BC van den Bosch MA | 2002 | Stroke2002，33，5： | 1 |
| 11 | Chlamydia pneumoniae, helicobacter pyloric and cytomegalovirus infections and the risk of peripheral arterial dis1ease in young women 显示文摘 | Bloemenkamp DG Mali WP Tanis BC | 2002 | Atheroselerosis2002，163，1： | 1 |
| 12 | Chemokines and chemokine receptors in inflammatory demyelinating neuropathies:a central role for IP-10显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，4： | 1 |
| 13 | Estrogens, progestogens and thrombosis 显示文摘 | Rosendaal FR Van Hylckama VA Tanis BC | 2003 | J Thromb Haemost2003，1，： | 1 |
| 14 | Effect of thyroid substitution on hypercholestrolaemia in patients with subclinical hypothyroidism:a reanalysis of intervention studies 显示文摘 | Tanis BC Westendorp GJ Smelt HM | 1996 | Clin1996，，6： | 1 |
| 15 | Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke 显示文摘 | Slooter AJ Rosendaal FR Tanis BC | 2005 | J Thromb Haemost2005，3，6： | 1 |
| 16 | Haplotypes encod- ing the factor VIII 1241 Glu variation and the risk of myocardial infarction显示文摘 | Nossent AY Eikenboom JC Tanis BC | 2007 | J Thromb Haemost2007，5，3： | 1 |
| 17 | Effect of thyroid substitutionon hypercholesterolaemia in patients with subclinical hypothyroid-ism:a reanalysis of intervention studies显示文摘 | Tanis BC Westendorp GJ Smelt HM | 1996 | Clin Endocrinol1996，44，6： | 1 |
| 18 | Chemokines and chemokine receptors in inflammatory dernyelinating neuropathies: a central role for IP-10显示文摘 | Kiesseier BC Tani M Mahad D | 2002 | Brain2002，125，4： | 1 |
| 19 | Chemokines and chemokine receptors in inflammatory demyelinating neuropathies:a central role for IP-10显示文摘 | Kieseier BC Tani M Mahad D | 2002 | Brain2002，125，： | 1 |
| 20 | Venous and arterial thrombosis during oral contraceptive use:risks and risk factors显示文摘 | Tanis BC Rosendaal FR | 2003 | Semin Vasc Med2003，3，1： | 1 |
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