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| 1 | Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea显示文摘AIM:To investigate the effect of Lactobacillus-containing commercially available probiotic formulations in Germany during antibiotic treatment with an analysis of cost-efficiency.METHODS:In an observational study,we analyzed the frequency of bowel movements from 258 patients with infections in a primary care hospital in western Germany;107 of the patients were offered a probiotic drink containing at least 10 billion cultures of Lactobacillus casei DN 114001 b.i.d.The economic analysis was based on the costs of patient isolation vs preventive intake of probiotics.In a second pilot study,two commercially available probiotic drinks with different Lactobacillus casei strains were directly compared in 60patients in a randomized controlled fashion.RESULTS:In the first study,the incidence of antibioticassociated diarrhea(AAD)was significantly reducedin the intervention group(6.5%vs 28.4%),and the duration of AAD in days was significantly shorter(1.7±1.1 vs 3.1±2.1).Higher age and creatinine and lower albumin were identified as risk factors for AAD.Ampicillin was the antibiotic with the highest rate of AAD(50%)and with the greatest AAD reduction in the probiotic group(4.2%,relative risk reduction 92%).The economic analysis showed a cost advantage of nearly60000€/year in a department of this size.The second study confirmed the preventive effect of the drink with Lactobacillus casei DN114001;however,there were no advantages found for the other tested probiotic drink containing Lactobacillus casei Shirota.CONCLUSION:In contrast to a drink containing Lactobacillus casei Shirota,a commercially available probiotic drink containing Lactobacillus casei DN 114001 costefficiently reduces the prevalence of AAD during antibiotic treatment. | Christoph G Dietrich Tanja Kottmann Manuela Alavi | 2014 | World Journal of Gastroenterology2014，20，42： | 14 |
| 2 | Orthotopic liver transplantation for giant liver haemangioma: A case report显示文摘In liver haemangiomas, the risk of complication rises with increasing size, and treatment can be obligatory. Here we present a case of a 46-year-old female who suffered from a giant haemangioma causing severe portal hypertension and vena cava compression, leading to therapy refractory ascites, hyponatremia and venostasis-associated thrombosis with pulmonary embolism. The patients did not experience tumour rupture or consumptive coagulopathy. Surgical resection was impossible because of steatosis of the non-affected liver. Orthotopic liver transplantation was identified as the only treatment option. The patient's renal function remained stable even though progressive morbidity and organ allocation were improbable according to the patient's lab model for end-stage liver disease(lab MELD) score. Therefore, non-standard exception status was approved by the European organ allocation network 'Eurotransplant'. The patient underwent successful orthotopic liver transplantation 16 mo after admission to our centre. Our case report indicates the underrepresentation of morbidity associated with refractory ascites in the lab MELD-based transplant allocation system, and it indicates the necessity of promptly applying for non-standard exception status to enable transplantation in patients with a severe clinical condition but low lab MELD score. Our case highlights the fact that liver transplantation should be considered early in patients with non-resectable, symptomatic benign liver tumours. | Undine G Lange Julian N Bucher Markus B Schoenberg Christian Benzing Moritz Schmelzle Tanja Gradistanac Steffen Strocka Hans-Michael Hau Michael Bartels | 2015 | World Journal of Transplantation2015，5，4： | 6 |
| 3 | Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn’s disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis显示文摘 | Julia Seiderer Fabian Schnitzler Stephan Brand Tanja Staudinger Simone Pfennig Karin Herrmann Katrin Hofbauer Julia Dambacher Cornelia Tillack Michael Sackmann Burkhard G?ke Peter Lohse Thomas Ochsenkühn | 2006 | Scandinavian Journal of Gastroenterology2006，，12： | 1 |
| 4 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 5 | Distinct Roles of Vascular Endothelial Growth Factor-D in Lymphangiogenesis and Metastasis 显示文摘 | Lucie K Tanja V Valentin G | 2007 | Am J Pathol2007，170，4： | 1 |
| 6 | Metal contamination of urban soils in the vicinity of a municipal waste incinerator:One source among many显示文摘 | DAVID L R CATHERINE G V TANJA PLESS-MULLOLI | 2006 | Science of The Total Enviroment2006，，356： | 1 |
| 7 | Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract显示文摘 | Tanja G Zunana C | 2006 | J Inflamma2006，3，1： | 1 |
| 8 | Porcine circovires type 2-associated disease: Update on current terminology, clinical manifestations,pathogenesis ,diagnosis, and intervention strategies 显示文摘 | TANJA OPRIESSNIG MENG Xiang-jin HALBUR P G | 2007 | Vet Diagn Invest2007，19，9： | 1 |
| 9 | Metal contamination of urban soils in the vicinity of a municipal waste incinerator: one source among many显示文摘 | Rimmer D L Vizard C G Tanja Pless-Mulloli T | 2006 | Sci Total Environ2006，356，13： | 1 |
| 10 | Experimental urethane anaesthesia prevents digoxin intoxication: electrocardiographic and histological study in rabbit 显示文摘 | Tanja P Giorgio D Vittorio G | 2000 | Pharmacol Res2000，42，4： | 1 |
| 11 | HPV 16 infection and pro-gression of cervical intra-epithelial neoplasia : Analysis of HLApolymorphism and HPV 16 E6 sequence variants 显示文摘 | Hetty J B Mark V D Tanja D D G | 1998 | Interna-tional Journal of Cancer1998，78，： | 1 |
| 12 | Metal contamination of urban soils in the vicinity of a municipal waste incinerator:One source among many显示文摘 | Rimmer D L Vizard C G Tanja P M | | 0，，1： | 1 |
| 13 | Inhibition of NF - κB activation and MMP - 9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol) 显示文摘 | Tanja G Zuzana C | 2006 | Journal of Inflammation2006，3，1： | 1 |
| 14 | Epilepsy in the elder- ly and depression显示文摘 | Dubravka SG Klementina R Tanja G | 2011 | Epilepsy2011，35，2： | 1 |
| 15 | From optimization of synbiotic microparticles prepared by spray-drying to development of new functional carrot juice显示文摘 | Tanja P I Lidija P T Anita G | 2014 | Chem Ind Chem Eng Q2014，20，4： | 1 |
| 16 | Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein显示文摘 | Leonille Schweizer Christian Koelsche Felix Sahm Rosario M. Piro David Capper David E. Reuss Stefan Pusch Antje Habel Jochen Meyer Tanja G?ck David T. W. Jones Christian Mawrin Jens Schittenhelm Albert Becker Stephanie Heim Matthias Simon Christel Herold- | 2013 | Acta Neuropathologica2013，，5： | 1 |
| 17 | 3-Substituted 2-phenyl-in- doles:privileged structures for medicinal chemistry 显示文摘 | HENRIK J TANJA B J DAVID E G | 2013 | RSC Advances2013，3，3： | 1 |
| 18 | Distinct Roles of Vascular Endothelial Growth Factor D in Lymphangiogenesis and Me tastasis显示文摘 | Lucie K Tanja V Valentin G | 2007 | Am J Pathol2007，170，4： | 1 |
| 19 | Effect of aluminium and pH on the mobility of phosphate through a soil-root interface model显示文摘 | CARLO E G TANJA M SALVATORE D | 2005 | Plant and Soil2005，272，： | 1 |
| 20 | Uranium in groundwater - Fertilizers versus geogenic sources 显示文摘 | Tanja L S?ren H Nico G | 2015 | Science of the Total Environment2015，536，1： | 1 |
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