|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion显示文摘AIM To examine the role that enzyme Acyl-CoA:diacylglycerol acyltransferase-1(DGAT1) plays in postprandial gut peptide secretion and signaling.METHODS The standard experimental paradigm utilized to evaluate the incretin response was a lipid challenge.Following a lipid challenge,plasma was collected via cardiac puncture at each time point from a cohort of 5-8 mice per group from baseline at time zero to 10 h.Incretin hormones [glucagon like peptide-1(GLP-1),peptide tyrosine-tyrosine(PYY) and glucose dependent insulinotropic polypeptide(GIP)] were then quantitated.The impact of pharmacological inhibition of DGAT1 on the incretin effect was evaluated in WT mice.Additionally,a comparison of loss of DGAT1 function either by genetic ablation or pharmacological inhibition.To further elucidate the pathways and mechanisms involved in the incretin response to DGAT1 inhibition,other interventions [inhibitors of dipeptidyl peptidase-IV(sitagliptin),pancreatic lipase(Orlistat),GPR119 knockout mice] were evaluated.RESULTS DGAT1 deficient mice and wildtype C57/BL6J mice werelipid challenged and levels of both active and total GLP-1 in the plasma were increased.This response was further augmented with DGAT1 inhibitor PF-04620110 treated wildtype mice.Furthermore,PF-04620110 was able to dose responsively increase GLP-1 and PYY,but blunt GIP at all doses of PF-04620110 during lipid challenge.Combination treatment of PF-04620110 and Sitagliptin in wildtype mice during a lipid challenge synergistically enhanced postprandial levels of active GLP-1.In contrast,in a combination study with Orlistat,the ability of PF-04620110 to elicit an enhanced incretin response was abrogated.To further explore this observation,GPR119 knockout mice were evaluated.In response to a lipid challenge,GPR119 knockout mice exhibited no increase in active or total GLP-1 and PYY.However,PF-04620110 was able to increase total GLP-1 and PYY in GPR119 knockout mice as compared to vehicle treated wildtype mice.CONCLUSION Collectively,these data provide some insight into the mechanism by which inhibition of DGAT1 enhances intestinal hormone release. | Benjamin S Maciejewski Tara B Manion Claire M Steppan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，4： | 2 |
| 2 | Nest building in captive Groilla gorilla gorilla显示文摘 | Krusten EL Tara SS Kyle B | 2001 | Inter J Primatol2001，24，： | 1 |
| 3 | Effeets of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans显示文摘 | Tara E Saekett G H Neil Towers Murray B Isman | 2007 | Chemoecology2007，17，： | 1 |
| 4 | Guy E An Adaptive Cross-layer Design for Multiservice Scheduling in OFDMA Based Mobile WiMAX Systems显示文摘 | Tara A Y Andre L B | | 0，，03： | 1 |
| 5 | Long-term response of yellow-pop-lar to thinning in the southern Appalachian Mountains显示文摘 | TARA L K PETER M B | 2014 | Forest Ecology and Management2014，312，： | 1 |
| 6 | Weed control in establishment of wildflower sods and meadows显示文摘 | ALVIN B TARA O B | 1995 | Northeastern Weed Science Society Proceedings1995，，49： | 1 |
| 7 | Efficacy of rectal misoprostol for prevention of postpartum hemorrhage显示文摘 | Mirteimouri M Tara F Teimouri B | 2013 | Iran J Pharm Res2013，，2： | 1 |
| 8 | Designing a performance measurement system to support materials management in engineer-to-order:a case study显示文摘There are many different production situations that can be employed to meet demand.In the engineer-toorder(ETO)production situation,products are manufactured to meet specific customer needs by unique engineering or significant customization.In such an environment,failing to supply the required materials in the right quantities and at the right time increases the risk of breaching due date agreements and thereby losing customer satisfaction.As such,materials management is one of the most important and critical processes within production planning and control in ETO.To bring attention and improvement to this area,ETO companies may benefit from a performance measurement system(PMS)that systematically monitors how well materials management is carded out.The design of a company's PMS varies with its production situation.Within the large body of literature on performance management and measurement,limited literature specifically addressing performance measurement in ETO has been identified.After being approached by a Norwegian ETO company requesting a PMS for materials management,the authors therefore set out to design the PMS from scratch,using literature on ETO,materials management and performance management and measurement as a starting point.The paper presents the proposed PMS.It provides a basis for further studies on the topic,and could be used by managers in ETO companies to assess and improve their materials management practice. | BФrge SjФbakk Ottar Baks Oksana Bondarenko Tara Kamran | 2015 | Advances in Manufacturing2015，3，2： | 1 |
| 9 | Efficacy of rectal misoprostol for prevention of postpartum hemorrhage显示文摘 | Mirteimouri M Tara F Teimouri B | 2013 | Iran J Pharrn Res2013，12，2： | 1 |
| 10 | Proton magnetic resonance spectroscopy study of brain metabolite changes af- ter antipsychotic treatment 显示文摘 | Szulc A Gali n iska B Taras o w E | 2011 | Pharmacopsychiatry2011，44，4： | 1 |
| 11 | Relationship between periodontal disease and diabetes mellitus:an Asian perspective显示文摘 | Tara B Renukanth P Rathna D | 2011 | Periodontology 20002011，56，1： | 1 |
| 12 | Liquid extraction of low molecular massorganic acids and hydroxamate siderophores from borealforest soil显示文摘 | Tara A Dan B | 2011 | Soil Biology&Biochemistry2011，85，43： | 1 |
| 13 | Negative Practice- Value Orientations in the GLOBE Data: Unexpected Findings, Questionnaire Limitations and Research Directions 显示文摘 | TARAS V STEEL p KIRKMAN B L | 2010 | Journal of International Business Studies2010，41，8： | 1 |
| 14 | Modeling Postilre Mortality of Ponderosa Pine Following a Mixed - Severity Wildfire in the Black Hills: The Role of Tree Morphology and Direct Fire Effects显示文摘 | Tara L Keyser Frederick W Smith Leigh B Lentile | 2006 | Forest Seience2006，52，5： | 1 |
| 15 | Trends in European drug pollices:a new beginning or more of the same显示文摘 | Lorenz B Tara S | 2004 | Journal Of Drug Issues2004，46，22： | 1 |
| 16 | Efficacy of rectal misoprostol for prevention of postpartum hemorrhage 显示文摘 | Mirteimouri M Tara F Teimouri B | 2013 | Iran J Pharm Res2013，12，2： | 1 |
| 17 | Genetic resources,genome mapping and evolutionary genomics of the pig(Sus scrofa)显示文摘 | Kefei C Tara B Muir W M | 2007 | International Journal of Biological Sciences2007，3，3： | 1 |
| 18 | The substrate-bound crystal structure of a Baeyer- Villiger monooxygenase exhibits a Criegee-like conformation 显示文摘 | YACHNIN B J TARA S MCEVOY M B | 2012 | J Am Chem Soc2012，134，18： | 1 |
| 19 | Mammary Tumor Develop- ment in Dogs Is Associated with BRCA1 and BRCA2 显示文摘 | Patricio R MalinM Tara B etal | 2009 | Cancer Res2009，69，20： | 1 |
| 20 | Acoustic event detection based on feature-level fusion of audio and video modalities显示文摘 | TARAS B CRISTIAN C CARLOS S | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员