|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Highly aligned rlbbon-shaped Pd nanoparticle assemblies by spontaneous organization 显示文摘 | Taratula O Chen A D Zhang J M | 2007 | J Phys Chem C2007，111，： | 1 |
| 2 | Inter- nallycationic polyamidoa mine PAMAM-OH den- drimers for siRNA delivery:effect of thedegree of quaternization and cancer targeting 显示文摘 | PATIL M L ZHANG M TARATULA O | 2009 | Biomacromol- eeules2009，10，2： | 1 |
| 3 | Tumor targe-ted quantum dot-mucin1aptamer-doxorubicin conjugate for imaging and treatment of cancer显示文摘 | Savla R Taratula O Garbuzenko O | 2011 | J Control Re-lease2011，153，： | 1 |
| 4 | Surface-engi- neered targeted PPI dendrimer for efficient intracellular and intratu- moral siRNA delivery显示文摘 | Taratula O Garbuzenko OB Kirkpatrick P | 2009 | J Control Release2009，140，3： | 1 |
| 5 | Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug Resistant Cancer Cells显示文摘 | Alex Chen Min Zhang Dongguang Wei Dirk Stueber Oleh Taratula Tamara Minko Huixin He | | 0，，23： | 1 |
| 6 | Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention显示文摘Objective: Various nanoparticles have been designed and tested in order to select optimal carriers for the inhalation delivery of anticancer drugs to the lungs. Methods: The following nanocarriers were studied: micelles, liposomes, mesoporous silica nanoparticles(MSNs), poly propyleneimine(PPI) dendrimer-siRNA complexes nanoparticles, quantum dots(QDs), and poly(ethylene glycol) polymers. All particles were characterized using the following methods: dynamic light scattering, zeta potential, atomic force microscopy, in vitro cyto- and genotoxicity. In vivo organ distribution of all nanoparticles, retention in the lungs, and anticancer effects of liposomes loaded with doxorubicin were examined in nude mice after the pulmonary or intravenous delivery. Results: Significant differences in lung uptake were found after the inhalation delivery of lipid-based and non-lipid-based nanoparticles. The accumulation of liposomes and micelles in lungs remained relatively high even 24 h after inhalation when compared with MSNs, QDs, and PPI dendrimers. There were notable differences between nanoparticle accumulation in the lungs and other organs 1 and 3 h after inhalation or intravenous administrations, but 24 h after intravenous injection all nanoparticles were mainly accumulated in the liver, kidneys, and spleen. Inhalation delivery of doxorubicin by liposomes significantly enhanced its anticancer effect and prevented severe adverse side effects of the treatment in mice bearing the orthotopic model of lung cancer.Conclusion: The results of the study demonstrate that lipid-based nanocarriers had considerably higher accumulation and longer retention time in the lungs when compared with non-lipid-based carriers after the inhalation delivery. These particles are most suitable for effective inhalation treatment of lung cancer. | Olga B.Garbuzenko Gediminas Mainelis Oleh Taratula Tamara Minko | 2014 | Cancer Biology & Medicine2014，11，1： | 1 |
| 7 | Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery显示文摘 | TARATULA O GARBUZENKO OB KIRKPATRICK P | 2009 | J Control Release2009，140，3： | 1 |
| 8 | Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and anticancer drug显示文摘 | Shah V Taratula O Garbuzenko OB | 2013 | Clin Cancer Res2013，19，22： | 1 |
| 9 | Targeted nanomedieine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and antieancer drug显示文摘 | Shah V Taratula O Garbuzenko OB | 2013 | Clin Cancer Res2013，19，22： | 1 |
| 10 | Surface- engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery 显示文摘 | Taratula O Garbuzenko OB Kirkpatrick P | 2009 | J Control Release2009，140，3： | 1 |
| 11 | Surface-engi- neered targeted PPI dendrimer for efficient intracellular and intra- tumoral siRNA delivery显示文摘 | Taratula O Garbuzenko OB Kirkpatrick P | 2009 | J Control Release2009，140，3： | 1 |
| 12 | Anti-HER2 IgY antibody-functionalized single-walled carbon nanotubes for detection and selective destruction of breast cancer cells 显示文摘 | XIAO Yan GAO Xiugong TARATULA O | 2009 | BMC Cancer2009，9，： | 1 |
| 13 | Multifunctional nanomedi- cine platform for cancer specific delivery of siRNA by superparamag- netie iron oxide nanopartieles-dendrimer complexes显示文摘 | Taratula O Garbuzenko O Savla R | 2011 | Cttrr Drug D- eliv2011，8，1： | 1 |
| 14 | Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplat- form for near-infrared fluorescence imaging and combinatorial anticancer phototherapy 显示文摘 | Taratula O Schumann C Duong T | 2015 | Nanoscale2015，7，9： | 1 |
| 15 | Muhifunctional nano- medicine platform for cancer specific delivery of siRNA by super- paramagnetic iron oxide nanoparticles-dendrimer complexes 显示文摘 | Taratula O Garbuzenko O Savla R | 2011 | Curr Drug Deliv2011，8，1： | 1 |
| 16 | Muhifunctional nanomedicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells显示文摘 | Taratula O Dani R K Schumann C | 2013 | International Journal of Pharmaceutics2013，458，1： | 1 |
| 17 | 显示文摘 | Nemec H Rochford J Taratula O | 2010 | Physical Review Letters2010，104，19： | 1 |
| 18 | Multifunctional nano- medicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells显示文摘 | Taratula O Dani RK Schumann C | 2013 | Int J Pharm2013，458，1： | 1 |
| 19 | Innovativestrategy for treatment of lung cancer: targeted nanotech-nology-based inhalation co-delivery of anticancer drugsand siRNA显示文摘 | Taratula O Garbuzenko OB Chen AM | 2011 | J Drug Target2011，19，10： | 1 |
| 20 | Nanostructuredlipid carriers as multifimctional nanomedicine platformfor pulmonary co-delivery of anticancer drugs and siRNA显示文摘 | Taratula O Kuzmov A Shah M | 2013 | J Control Release2013，171，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员