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| 1 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 2 | Insulin- stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipoeytes显示文摘 | PALMER D G RUTTER G A TAVARE J M | 2002 | Biochem Bio- ph Res Commun2002，291，3： | 1 |
| 3 | Increased resistance to systemic candidiasis in athymic or interleukin-10-depleted mice显示文摘 | Tavares D Ferreira P Arala-Chaves M | 2000 | J Infect Dis2000，182，： | 1 |
| 4 | Automatic small bowel tumor diagnosis by u?sing multi-scale wavelet-based analysis in wireless cap?sule endoscopy images显示文摘 | Barbosa D C Roupar D B RamosJ C Tavares A C Li?rna C S | 2012 | Biomed Eng Online2012，11，： | 1 |
| 5 | Serf - reported and neuropsychological measures of impulsivity in pathological gambling显示文摘 | Fuentes D Tavares H Aries R | 2006 | J Int Neuropsychol Soc2006，12，： | 1 |
| 6 | Structure - activity relationships of new A, D - ring modified steroids as aromatase inhibitors : design, synthesis, and biological activity evaluation 显示文摘 | Cepa M M Tavares D Silva E J | 2005 | Journal of Medicinal Chemistry2005，48，20： | 1 |
| 7 | Urban air pollution in Brazil: acetaldehyde and other carbonyls 显示文摘 | Grosjean D Miguel A H Tavares T M | 1990 | Atmos Environ1990，24，1： | 1 |
| 8 | Increased resistance to systemic candidiasis in athymic or interleukin-lO-depleted mice 显示文摘 | Tavares D Ferreira P Arala-Chaves M | 2000 | J Infect Dis2000，182，1： | 1 |
| 9 | Seismic Fragility of a Highway Bridge in Quebec 显示文摘 | TAVARES D H SUESCUN J R PAULTRE P | 2013 | Journal of Bridge Engineering2013，18，11： | 1 |
| 10 | Polymer blends based on polyolefin elastomer and polypropylene 显示文摘 | SILVA A L N D TAVARES M I B POLITANO D P | 1997 | J Appl Polym Sci1997，66，10： | 1 |
| 11 | Influence of particle size and specific surface area on the pozzolanic activity of residual rice husk ash 显示文摘 | CORDEIRO G C FILHO R D T TAVARES L M | 2011 | Cem Concr C ompos2011，33，： | 1 |
| 12 | Polo-like kinases:a team that plays throughout mitosis显示文摘 | Glover D M Hagan I M Tavares A A | 1998 | Genes Dev1998，12，24： | 1 |
| 13 | Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: A c-fos study in acute and chronic articular inflammation显示文摘 | Pinto M Lima D Tavares I | 2007 | Neuroscience2007，147，4： | 1 |
| 14 | Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irra- diation in the prevention of transfusion-associated graft-versus-hostdisease? 显示文摘 | Fast L D Nevola M Tavares J | 2013 | Transfusion2013，53，2： | 1 |
| 15 | Live cell imaging reveals actin-cytoskeleton-induced self-association of the actin-bundling protein WLIM1显示文摘 | Hoffmann C Moes D Dieterle M Neumann K Moreau F Tavares F A Dumas D Stein- metz A Thomas C | 2014 | Journal of Cell Science2014，127，3： | 1 |
| 16 | The hydrologic impacts of long-term afforestation in an upland watershed in north-central Portugal显示文摘 | HAWTREE D FEGER K TAVARES F | 2014 | International Forestry Review2014，16，5： | 1 |
| 17 | Effect of high temperature annealing on texture and microstructure on an AISI-444 ferritic stainless steel显示文摘 | de Abreu H F G Bruno A D S Tavares S S M | 2006 | Materials Characterization2006，57，45： | 1 |
| 18 | Effect of foliar and substrate fertilization on lady palm seedling growth and development显示文摘 | Da Luz P B Patrcia Duarte de 0liveira Paiva P D Tavares A R | | 0，，： | 1 |
| 19 | The Use of Thermomagnetic Analysis for Detection and Quantification of 475 ℃ Embrittlement of Duplex Stainless Steels 显示文摘 | da Silva M R Tavares S S M Fruchart D | 2001 | Journal of Magnetism and Magnetic Materials2001，226，2302： | 1 |
| 20 | New spectroscopic results of trivalent chromium in magnesium gallate显示文摘 | SOSMAN L P FONSECA R J M TAVARES J A D | 2007 | Journal of Physics and Chemistry of Solids2007，68，1： | 1 |
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