|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunogenicity and protective efficacy of recombinant M2e.Hsp70c(Hsp70_(359–610)) fusion protein against influenza virus infection in mice显示文摘New strategies in vaccine development are urgently needed to combat emerging influenza viruses and to reduce the risk of pandemic disease surfacing. Being conserved, the M2 e protein, is a potential candidate for universal vaccine development against influenza A viruses. Mycobacterium tuberculosis Hsp70(mHsp70) is known to cultivate the function of immunogenic antigen-presenting cells, stimulate a strong cytotoxic T lymphocyte(CTL) response, and stop the induction of tolerance. Thus, in this study, a recombinant protein from the extracellular domain of influenza A virus matrix protein 2(M2e), was fused to the C-terminus of Mycobacterium tuberculosis Hsp70(Hsp70c), to generate a vaccine candidate. Humoral immune responses, IFN-γ-producing lymphocyte, and strong CTL activity were all induced to confirm the immunogenicity of M2 e.Hsp70c(Hsp70359–610). And challenge tests showed protection against H1N1 and H9N2 strains in vaccinated groups. Finally these results demonstrates M2 e.Hsp70c fusion protein can be a candidate for a universal influenza A vaccine. | Hamidreza Attaran Hassan Nili Majid Tebianian | 2014 | Virologica Sinica2014，29，4： | 2 |
| 2 | Cloning, expression, and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70 显示文摘 | Tebianian M Hoseini AZ Ebrahimi SM | 2011 | Biologicals2011，39，3： | 1 |
| 3 | Influenza A viruses: why focusing on M2e-based universal vaccines显示文摘 | EBRAHIMI S M TEBIANIAN M | 2011 | Virus Genes2011，42，1： | 1 |
| 4 | Cloning, expression and purification of the influenza A (H9N2) virus M2e antigen and truncatedMycobacterium tuberculosis HSP70 as a fusion protein in Pichia pastoris显示文摘 | Ebrahimi M Tebianian M Toghyani H | 2010 | Protein Expression and Purification2010，70，： | 1 |
| 5 | Cloning, expression, and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70显示文摘 | Majid Tebianian Ahmad Zavaran Hoseini Seyyed Mahmoud Ebrahimi Arash Memarnejadian Ali Rezaei Mokarram Mehdi Mahdavi Nooshin Sohrabi Morteza Taghizadeh | 2011 | Biologicals2011，，3： | 1 |
| 6 | Heterologous expression, purification and characterization of the influenza A vi- rus M2e gene fused to Mycobacterium tuberculosis HSP70(359-610) in prokaryotic system as a fusion pro- tein 显示文摘 | Ebrahimi S M Tebianian M | 2010 | Mol Biol Rep2010，37，6： | 1 |
| 7 | Cloning,expression,and immunogenicity of novel fusion protein of Mycobacterium tuberculosis based on ESAT-6 and truncated C-terminal fragment of HSP70显示文摘 | Majid Tebianian Ahmad Zavaran Hoseini Seyyed Mahmoud Ebrahimi | 2011 | Biologicals2011，39，： | 1 |
| 8 | Influenza A viruses: why focusing on M2e-based universal vaccines 显示文摘 | Ebrahimi S Tebianian M | 2011 | Virus Genes2011，42，1： | 1 |
| 9 | Influenza A viruses: why focus- ing on M2e-based universal vaccines显示文摘 | Ebrahimi S M Tebianian M | 2011 | Virus Genes2011，42，1： | 1 |
| 10 | Heterologous expres- sion, purification and characterization of the influenza a virus M2e gene fused to Mycobacteriurn tuberculosis HSP70359- 610 in prokaryotic system as a fusion protein显示文摘 | EBRAHIMI S M TEBIANIAN M | 2010 | Molecular Biology Reports2010，37，6： | 1 |
| 11 | Experimental characterization and CFD simulation of gas maldistribution in turbulent fluidization of Group A particles显示文摘The study presented hereby investigates experimentally and with CFD simulations the gas distribution effect on the hydrodynamic of a Geldart Group A turbulent fluidized bed. Experiments were carried out on a cold flow fluidized bed column with an even and uneven gas distribution. Local solid volume fraction profiles were measured using optical probes at different bed heights and along two radial directions. Optical probe measurements allow catching a clear hydrodynamic difference between both even and uneven gas distributions. These results were then used to assess CFD simulations with the code Barracuda^(TM) (MP-PIC approach). It is noteworthy that the choice of drag correlation and boundary conditions strongly influences the agreement between the experimental and CFD results. Once the correct parameters are chosen, CFD simulations captured the effect of gas distribution changes. | Maurizio Troiano Benjamin Amblard Sina Tebianian Roberto Solimene Piero Salatino Thierry Gauthier | 2023 | Particuology2023，，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员