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| 1 | Editorial显示文摘Founded only six years ago, the National Center for Nanoscience and Technology (NCNST) has developed rapidly withimportant achievements. We invited experts of NCNST in this field to introduce the research developments by NCNST | K. Ted Thurn Eric M. B. Brown Aiguo Wu Stefan Vogt Barry Lai et al. | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 2 |
| 2 | Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway显示文摘 | KATHLEEN C BROWN TED R | 2010 | PLoS One2010，5，10： | 1 |
| 3 | Expansion of the fragile X CGG repeat in females with pre-mutation or intermediate alleles显示文摘 | Sarah L Nolin W Ted Brown | 2003 | Am J Hum Genet2003，72，： | 1 |
| 4 | Is New Urbanism the Cure?A Look at Central Florida's Response显示文摘 | Brown Ted R Bonifay Cecelia | 2001 | Real Estate Issues2001，26，3： | 1 |
| 5 | NF- κ B Signaling in the Brain of Autistic Subjects显示文摘 | Mazhar Malik Zujaja Tauqeer Ashfaq M. Sheikh Guang Wen Amenah Nagori Kun Yang W. Ted Brown Xiaohong Li Giuseppe Valacchi | 2011 | Mediators of Inflammation2011，，： | 1 |
| 6 | An eval- uation of the construct validity of the developmental test of visual-motor integration using the Rasch Measurement model 显示文摘 | Ted Brown Carolyn Unsworth and Carissa Lycms | 2009 | Australian Oceupational Therapy Journal2009，56，： | 1 |
| 7 | Genetic diversity, population structure and genome-wide marker-trait association analysis emphasizing seed nutrients of the USDA pea (Pisum sativum L.) core collection显示文摘 | Soon-Jae Kwon Allan Brown Jinguo Hu Rebecca McGee Chasity Watt Ted Kisha Gail Timmerman-Vaughan Michael Grusak Kevin McPhee Clarice Coyne | 2012 | Genes & Genomics2012，，3： | 1 |
| 8 | Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway显示文摘 | KATHLEEN C BROWN TED R | 2010 | PLoS One2010，5，10： | 1 |
| 9 | Increased expression of β-catenin in brain microvessels of a segmentally trisomic (Ts65Dn) mouse model of Down syndrome显示文摘 | Andrzej W. Vorbrodt Shuyun Li W. Ted Brown Narayan Ramakrishna | 2008 | Brain Cell Biology (-)2008，，5： | 1 |
| 10 | Intracellular in situ labeling of Ti02 nanoparticles for fluorescence microscopy detection显示文摘 | Koshonna Brown Ted Thurn Lun Xin William Liu Remon Bazak Si Chen Barry Lai Stefan Vogt Chris Jacobsen Tatjana Paunesku Gayle E. Woloschak | 2018 | Nano Research2018，11，1： | 0 |
| 11 | Progerin作用的伴侣蛋白和核纤层蛋白间的相互作用:在早老症中Me118与emerin的相互作用(英文)显示文摘Objective:The Hutchinson-Gilford progeria syndrome (HGPS or progeria) is a childhood disorder with features of premature aging and is caused by mutations in the lamin A gene resulting in the production of an abnormal protein,termed progerin. To investigate the underlying pathogenic mechanism,we studied the nuclear co-localization and association of progerin interactive partner proteins (PIPPs) with lamina proteins. Methods:Both wild-type (WT) and progeria fibroblasts were studied by various methods including confocal microscopy,immunoprecipitation and Western blot.Results:All PIPPs discovered so-far co-localized with lamin A/C. In addition,the PIPPs were selectively associated with lamina proteins. An increased immunofluorescent staining signal was found for Mel18 in HGPS as compared to WT cells. An association of Mel18 with emerin was observed in HGPS,but not in WT cells. Conclusion:Based on these findings,we propose that PIPPs,along with associated lamina proteins may form a pathogenic progerin-containing protein complex. | W. Ted BROWN Nanbert ZHONG | 2009 | 北京大学学报(医学版)2009，41，4： | 0 |
| 12 | PCBP1的新伴侣蛋白分子的研究(英文)显示文摘Objective:PCBP1 is a family member of heterogeneous nuclear ribonucleoproteins (hnRNPs) that belong to RNA-binding proteins and bear three KH domains. The protein plays a pivotal role in post-transcriptional regulation for RNA metabolism and RNA function in gene expression. We hypothesized and were going to identify that the regulatory function of PCBP1 is performed through different complexes of proteins that include PCBP1. Methods:To test our hypothesis,approaches of protein wal-king with a yeast two-hybrid system (Y2H),pulling down in yeasts,co-immunoprecipitation and immunofluorescent microscopy assay were employed in this study. The PCBP1 was used as the initial 'walker' to search for its interaction partner(s). Results:Candidate proteins including MYL6,PECAM1,CSH1,RAB7,p57KIP2,ACTG1,RBMS1 and PSG4-like were identified with selection mediums and preceding methods. Conclusion:With these candidate protein molecules,some protein complexes associating with PCBP1 are proposed,which may help in a better understanding of physiological functions of PCBP1 and proved evidence that PCBP1 is involved in variant biological pathways. | 霍丽蓉 申晨 Wei-na JU 邹俊华 闫武 W. Ted BROWN Nanbert ZHONG | 2009 | 北京大学学报(医学版)2009，41，4： | 0 |
| 13 | 胃复安肠外给药治疗急性偏头痛:多项随机对照试验的汇总分析显示文摘目的:通过分析多项对照试验结果,评价胃复安肠外给药对于成人急性偏头痛的疗效和患者耐受性。资料来源:Cochrane对照试验中心注册材料,Medline,Embase,LILACS,CINAHL,会议记录,临床实践指南及其他资源。 | lan Colman Michael D Brown Grant D Innes Eric Grafstein Ted E Roberts Brian H Rowe 朱丽琳 | 2005 | 英国医学杂志中文版2005，8，2： | 0 |
| 14 | 神经元蜡样质脂褐质沉积病(NCL)的基因型与表型相关性研究(英文)显示文摘Objective:Genotype-phenotype associations were studied in 517 subjects clinically affected by classical neuronal ceroid lipofuscinosis (NCL). Methods:Genetic loci CLN1-3 were analyzed in regard to age of onset, initial neurological symptoms, and electron microscope (EM) profiles. Results: The most common initial symptom leading to a clinical evaluation was developmental delay (30%) in NCL1, seizures (42.4%) in NCL2, and vision problems (53.5%) in NCL3. Eighty-two percent of NCL1 cases had granular osmiophilic deposits (GRODs) or mixed-GROD-containing EM profiles; 94% of NCL2 cases had curvilinear (CV) or mixed-CV-containing profiles; and 91% of NCL3 had fingerprint (FP) or mixed-FP-containing profiles. The mixed-type EM profile was found in approximately one-third of the NCL cases. DNA mutations within a specific CLN gene were further correlated with NCL phenotypes. Seizures were noticed to associate with common mutations 523G>A and 636C>T of CLN2 in NCL2 but not with common mutations 223G>A and 451C>T of CLN1 in NCL1. Vision loss was the initial symptom in all types of mutations in NCL3. Surprisingly, our data showed that the age of onset was atypical in 51.3% of NCL1 (infantile form) cases, 19.7% of NCL2 (late-infantile form) cases, and 42.8% of NCL3 (juvenile form) cases.Conclusion:Our data provide an overall picture regarding the clinical recognition of classical childhood NCLs. This may assist in the prediction and genetic identification of NCL1-3 via their characteristic clinical features. | Weina JU Anetta WRONSKA Dorota N. MOROZIEWICZ Rocksheng ZHONG Natalia WISNIEWSKI Anna JURKIEWICZ Michael FIORY Krystyna E. WISNIEWSKI Lance JOHNSTON W. Ted BROWN Nanbert ZHONG | 2006 | 北京大学学报(医学版)2006，38，1： | 0 |
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