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| 1 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 2 | PrevaLence of urinary tract infection and renaL scars in patients with diabetes meLLitus显示文摘 | Goswam I R BaL C S Teja S W | 2001 | Diabetes Res CLin Pract2001，53，3： | 1 |
| 3 | Synthesis,propertias,andapplications of magnetic iron oxide nanoparticles显示文摘 | TEJA A S KOH P Y | | 0，，1： | 1 |
| 4 | A new cubic equation of state for fluids and fluid mixtures显示文摘 | PATEL N C TEJA A S | 1982 | Chemical Engi-neering Science1982，37，3： | 1 |
| 5 | Characteristics of lithium iron phosphate (LiFePO4) particles synthesized in subcritical and supercri- tical water显示文摘 | Lee J Teja A S | 2005 | J Supereritical Fluids2005，35，1： | 1 |
| 6 | Solubilities of diamondoids in supercritical solvents显示文摘 | Smith Vicky S Teja Amyn S | 1996 | Journal of Chemical and Engineering Data1996，41，4： | 1 |
| 7 | Densities of acetic acid +water mixtures at high temperature and concentrations显示文摘 | SUN T F Ly D Teja A S | 1995 | Ind Eng Chem Res1995，34，4： | 1 |
| 8 | A New Model Reference Adaptive Controller for Four Quadrant Vector Controlled Induction Motor Drives显示文摘 | A V Ravi Teja C Chakraborty S Maiti Y Hori | 2012 | IEEE Transactions on Industrial Elec- tronics2012，59，： | 1 |
| 9 | Microvascular decompression for trigeninal neuralgia显示文摘 | Allende R Teja S Alleyne CH Jr | 2001 | Neurology2001，57，6： | 1 |
| 10 | Vapor - liquid ctitieal properties of elements and compounds, 4 aliphatic alkanols 显示文摘 | GUDE M TEJA A S | 1995 | J Chem Eng Data1995，40，5： | 1 |
| 11 | Solubility of long-chain n-Alkanes in heptane between 280 and 350 K显示文摘 | Robert K L Rousseau R W Teja A S | 1994 | J Chem Eng Data1994，39，4： | 1 |
| 12 | The solubility of solids in supercritical fluids显示文摘 | Satiago J M Teja A S | 1999 | Fluid Phase Equilib1999，158，1： | 1 |
| 13 | High Pressure Phase Equilibria in the Carbon Dioxide -n -hexadecane and Carbon Dioxide - water Systems 显示文摘 | D 'souza R Patrick J R Teja A S | 1988 | The Canadian Jour-nal of Chemical Engineering1988，66，2： | 1 |
| 14 | Solubility of monocrotaline in supercritical carbon dioxide and carbon dioxide-ethanol mixture显示文摘 | SCHAEFFER S T ZALKOW L H TEJA A S | 1988 | Fluid Phase Equilibria1988，43，： | 1 |
| 15 | Solubility of long-chain n-alkanes in heptane between 280 and 350K显示文摘 | Roberts K L Rousseau RW Teja A S | | 0，，04： | 1 |
| 16 | Solubility and diffusion of carbon dioxide in polymers显示文摘 | Webb K F Teja A S | 1999 | Fluid Phase Equilibria1999，158，： | 1 |
| 17 | Prevalence of urinary tract infection and renalscars in patients with diabete smellitus显示文摘 | Goswan I R Bal C S Teja S W | 2001 | Diabetes Res Clin Pract2001，53，3： | 1 |
| 18 | High pressure phase equilibria in the carbon dioxide-n-hexadecane and carbon dioxide-water systems 显示文摘 | D'Souza Rupert Patrick J R Teja A S | 1988 | Can J Chem Eng1988，66，： | 1 |
| 19 | Supercritical extraction and HPLC analysis of taxol from Taxus brevifolia using nitrous oxide and nitrous oxide ethanol mixtures显示文摘 | Vandana V Teja A S Zalkow L H | 1996 | Fluid Phase Equilib1996，116，： | 1 |
| 20 | Synthesis, Properties, and applications of magnetic iron oxide nanoparticles显示文摘 | Teja Amyn S Koh Pei-Yoong | 2009 | Progress in Crystal Growth and Characterization of Materials2009，55，12： | 1 |
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