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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Incidence and risk faction of benigy creatine phosphokinase elevation in chronic psychiatric patients显示文摘 | Tero T Matsuda S Kojima H | 1999 | Neuropsychobiology1999，39，： | 1 |
| 3 | Two methods for fast ray- cast ambient occlusion显示文摘 | Laine S Karras Tero | 2010 | Computer Graphics Fo- rum2010，29，4： | 1 |
| 4 | Time - resolved EPR studies on thr photochemical hydrogen abstraction reactions and the excited triplet states of 4-substituted pyridines显示文摘 | Tero - Kubata S | 1991 | J Phys Chem1991，95，： | 1 |
| 5 | Rules for biologically in- spired adaptive network design显示文摘 | A Tero S Takagi T Saigusa | 2010 | Science2010，327，5964： | 1 |
| 6 | Rules for biologically inspired adaptive network design显示文摘 | ] TERO A TAKAOI S SAIGUSA T | 2010 | Science2010，327，： | 1 |
| 7 | AFM characteriza- tion of gramicidin-A in tethered lipid membrane on silicon sur- face 显示文摘 | LEI S B TERO R MISAWA N | 2006 | Chemical Physics Letters2006，429，13： | 1 |
| 8 | Effects of recombinant hu man IGF-I/IGF-binding protein 3 complex on glucose and glyc erol metabolism in type 1 diabetes 显示文摘 | Tero S Fariba S M Rachel M | 2006 | Diabetes2006，55，： | 1 |
| 9 | Cemented or uncemented hemiarthroplasty for the treatment of femoral neck fractures 显示文摘 | Tero YK Reijo S Mikkl H | 2014 | Acta Orthop2014，85，1： | 1 |
| 10 | A review in design and manufacturing of stainless steel sandwich panels显示文摘 | Jukka S yn j kangas Tero Taulavuori | 2004 | Stainless Steel World2004，11，： | 1 |
| 11 | Cardiovascular risk factors in liver allograft recipients :relationship with immunosuppressive therapy显示文摘 | Varo E Padin EO tero S | 2002 | Transplant Proc2002，34，： | 1 |
| 12 | Increased diagnosis of primary aldosteronism, including surgically correctable forms in centers from five con,tinen,ts显示文摘 | Mula tero P S towasser M l oh KC e t al | | J Clin Endocrinol Me''tab 200 10，89，3： | 1 |
| 13 | Inkjet printing of electrically conductive patterns of carbon nanotubes显示文摘 | Tero M Krisztián K Sami S | 2007 | Physica Status Solidi (b)2007，244，11： | 1 |
| 14 | Luminescent energy transfer between cadmium telluride nanoparticle and lanthanide (III) Chelate in competitive bioaffinity assays ofbiotin and estradiol显示文摘 | Harri H Tero S Alexey S | 2007 | Analytica Chimica Acta2007，604，2： | 1 |
| 15 | Chronic Exercise Increases Plasma Brain-Derived Neu- rotrophic Factor Levels, Pancreatic Islet Size, and Insulin Tolerance in a TrkB-Dependent Manner显示文摘 | JIMENEZ-MALDONADO A de ALVAREZ-BUYLLA E R MON- TERO S | 2014 | PLoS One2014，9，15： | 1 |
| 16 | Effects of recombinant human IGF-Ⅰ/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes显示文摘 | Tero S Fariba S M Rachel M l | 2006 | Diabetes2006，55，： | 1 |
| 17 | Rules for Biologically Inspired Adaptive Network Design 显示文摘 | TERO A TAKAGI S SAIGUSA T | 2010 | Science Signa ling2010，327，5964： | 1 |
| 18 | Rules for biologically inspired adaptive network design 显示文摘 | Tero A Takagi S Saigusa T | 2010 | Science2010，327，5964： | 1 |
| 19 | Coagulation and uhrafihration : understanding of the key parameters of the hybrid process 显示文摘 | BARBOT E MOUSTIER S BOq'TERO J | 2008 | Journal of Membrane Science2008，325，： | 1 |
| 20 | Incidence and risk faction of benigy creatine phosphokinase elevation in chronic psychiatric patients显示文摘 | Tero T Matsuda S Kojima H | 1999 | Neuropsychobiology1999，39，2： | 1 |
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