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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | The development and evolution of an improved genetic algorithm based on migration on artificial selection 显示文摘 | Pott J C Terri D G Surya B Y | 1994 | IEEE Transcation on SAC1994，，： | 1 |
| 3 | Atomic force micro-scopy imaging of hair: Correlations between surface potential and wetting at the nanometer scale显示文摘 | Vincent D Terri C Dominique L | 2004 | Journal of Colloid and Interface Science2004，269，2： | 1 |
| 4 | 显示文摘 | Azibuke D C Chrysanthou A | 1994 | Scand J Metall1994，23，3： | 1 |
| 5 | Sensors and Actuators显示文摘 | Allen H V Terry S C De Bruin D W | 1989 | 20:153-1611989，20，： | 1 |
| 6 | 显示文摘 | Azibuke D C Chrysanthou A | 1994 | J Mater Science1994，29，16： | 1 |
| 7 | The Development and Evolution of an Unproved Genetic Algorithm Based on Migration and Artificial Selection显示文摘 | POTTS J C TERRI D G SURYA B Y | 1994 | IEEE Transactions on SMC1994，24，1： | 1 |
| 8 | Elicitors of induced resistance in postharvest horticultural crops: a brief review 显示文摘 | TERRY L A JOYCE D C | 2004 | Postharvest Biolo- gy and Technology2004，32，： | 1 |
| 9 | 1 - methylcyclopropene treatment affects strawberry fruit decay显示文摘 | Jiang Y M Joyce D C Terry L A | 2001 | Postharvest Biol Theclnol2001，，23： | 1 |
| 10 | 1 -MCP treatment affects strawberry fruit decay显示文摘 | Jiang Y Joyce D C Terry L A | 2001 | Postharvest Bio and Tech2001，23，： | 1 |
| 11 | 1-Methylcyclpropene treatment affect strawberry fruit decay显示文摘 | Jiang Y Joyce D C Terry L A | 2001 | Posthasvest Biol Technol2001，23，： | 1 |
| 12 | Yield models implied by traditional fertilizer recommendations and a framework for including nontra- ditional information 显示文摘 | Terry L K John P S Kevin C D | 2003 | Soil Sci Soc Am J2003，67，： | 1 |
| 13 | The development and evolution of an improved genetic algorithm based on migration on artificial selection 显示文摘 | J C Potts D G Terri B Y Surya | 1994 | IEEE Trans on SAC1994，24，1： | 1 |
| 14 | Looking forward but learning from our past; Potential challenges to developing authentic leadership theory and authentic leaders显示文摘 | Cecily D C Terri A S Chester A S | 2005 | The Leadership Quarterly2005，16，： | 1 |
| 15 | Marketing Actions and the Value of Customer Asset显示文摘 | Berger P D Bolton R N Bowman D Briggs E Kumar V Parasuraman A Terry C | 2002 | Journal of Services Research2002，15，1： | 1 |
| 16 | Comparing the rheology of native spider and silkworm spinning dope显示文摘 | Holland C Terry A E Porter D | 2006 | Nature Materials2006，5，11： | 1 |
| 17 | The uncovered set and indifference in spatial models: a fuzzy set approach显示文摘 | John N M Terry D C Nicholas R M | 2011 | Fuzzy Sets and Systems2011，168，1： | 1 |
| 18 | Whither scenic beauty Visual landscape quality assessment in the century显示文摘 | Terry C D | 2001 | landseape and urban planning2001，，54： | 1 |
| 19 | Elicitors of induced disease resistance in postharvest horticultural crops:a brief review 显示文摘 | Terry L A Joyce D C | 2004 | Postharvest Biology and Technology2004，32，1： | 1 |
| 20 | 显示文摘 | Azubike D C | 1990 | Trans Inst Min Metall1990，99，9： | 1 |
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