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| 1 | Efficacy of 1.2L polyethylene glycol plus ascorbic acid for bowel preparations显示文摘BACKGROUND A low-volume polyethylene glycol(PEG) solution that combines ascorbic acid with PEG-based electrolyte solution(PEG-ASC) is gaining mainstream acceptance for bowel preparation due to reduced volume and improved taste.Although several reports showed that bowel preparation with PEG-ASC volume lower than 2.0 L with laxative agents could be an alternative to traditional preparation regimen, the cleansing protocols have not been fully investigated.AIM To evaluate the cleansing efficacy of 1.2 L PEG-ASC solution comparing with 2.0 L PEG electrolyte(PEG-ELS) for bowel preparations.METHODS A randomized, single-blinded, open-label, single-center, non-inferiority study was conducted. In total, 312 Japanese adult patients(aged > 18 years) who underwent colonoscopy were enrolled. Patients were randomly allocated to bowel lavage with either 1.2 L of PEG-ASC solution with at least 0.6 L of an additional clear fluid(1.2 L PEG-ASC group) or 2.0 L of PEG-ELS(PEG-ELS group). Then, 48 mg of sennoside was administered at bedtime on the day before colonoscopy, and the designated drug solution was administered at the hospital on the day of colonoscopy. Bowel cleansing was evaluated using the Boston Bowel Preparation Scale(BBPS). The volume of fluid intake and required time for bowel preparation were evaluated. Furthermore, compliance, patient tolerance,and overall acceptability were evaluated using a patient questionnaire, which was assessed using a visual analog scale.RESULTS In total, 291 patients(1.2 L PEG-ASC group, 148; PEG-ELS group, 143) completed the study. There was no significant difference in successful cleansing, defined as a BBPS score ≥ 2 in each segment, between the two groups(1.2 L PEG-ASC group, 91.9%; PEG-ELS group, 90.2%; 95%CI:-0.03-0.09). The required time for bowel preparation was significantly shorter(164.95 min ± 68.95 min vs 202.16 min± 68.69 min, P < 0.001) and the total fluid intake volume was significantly lower(2.23 L ± 0.55 L vs 2.47 L ± 0.56 L, P < 0.001) in the 1.2 L PEG-ASC group than in the PEG-ELS group. Palatability, acceptability of the volume of solution, and overall acceptability evaluated using a patient questionnaire, which was assessed by the visual analog scale, were significantly better in the 1.2 L PEG-ASC group than in the PEG-ELS group(7.70 cm ± 2.57 cm vs 5.80 cm ± 3.24 cm, P < 0.001). No severe adverse event was observed in each group.CONCLUSION The 1.2 L PEG-ASC solution was non-inferior to the 2.0 L PEG-ELS solution in terms of cleansing efficacy and had better acceptability among Japanese patients. | Hiroyuki Tamaki Teruyo Noda Masahiro Morita Akina Omura Atsushi Kubo Chikara Ogawa Toshihiro Matsunaka Mitsushige Shibatoge | 2019 | World Journal of Clinical Cases2019，7，4： | 4 |
| 2 | Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury显示文摘 | Masashi Tamaoki Kyoko Imanaka-Yoshida Kazuto Yokoyama Tomohiro Nishioka Hiroyasu Inada Michiaki Hiroe Teruyo Sakakura Toshimichi Yoshida | 2005 | The American Journal of Pathology2005，，： | 2 |
| 3 | Appiication of NT-proBNP and BNPmeasurements in care:a more discerning marker for the detection and evaluation of heart failure显示文摘 | Yoshihiko S Teruyo Y | 2004 | The European Journal of heart Failure2004，，： | 1 |
| 4 | Mammary Stroma in Development and Carcinogenesis显示文摘 | Teruyo Sakakura Yuka Suzuki Robert Shiurba | 2013 | Journal of Mammary Gland Biology and Neoplasia2013，，2： | 1 |
| 5 | Effects of bone marrow stromal cell injection in an experimental glaucoma model显示文摘 | Saiyuu Yu Teruyo Tanabe Mari Dezawa Hiroto Ishikawa Nagahisa Yoshimura | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 6 | Application of NT-proBNP and BNP measurements in care:a more discerning marker for the detection and evaluation of heart failure显示文摘 | Yoshihiko S Teruyo Y | 2004 | The European Journal of Heart Failure2004，6，3： | 1 |
| 7 | Application of NTpro BNP and BNP measurements in cardiac care:a more discerning marker for the detection and evaluation of heart failure显示文摘 | Yoshihiko S Akio O Teruyo Y | 2004 | Eur J Heart Fail2004，6，： | 1 |
| 8 | Fixation Behavior in Advanced Stage Glaucoma Assessed by the MicroPerimeter MP-1显示文摘 | Takanori Kameda Teruyo Tanabe Masanori Hangai | | 0，，： | 1 |
| 9 | Application of NT-probNP and BNP measurements in care:a more discerning marker for the detection and evaluation of heart failure显示文摘 | Yoshihiko S Teruyo Y | 2004 | The European Journal of heart Failure2004，，： | 1 |
| 10 | A practical synthesis of threo-3-amino-2-hydroxy earboxylie acids显示文摘 | Fuyuhik M Teruyo M Masako O | 1992 | Bull Chem Soc Jpn1992，65，： | 1 |
| 11 | Acquisition of methicillin resistance and progression of multiantibiotic resistance in methicillin-resistant staphylococcus aureus显示文摘 | Teruyo I Keiichi H | 1998 | Yonsei Med J1998，6，39： | 1 |
| 12 | Application of NT-proBNP and BNP measurements in cardiac care:a more discerning marker for the detection and evaluation of heart failure 显示文摘 | Yoshihiko S Akio O Teruyo Y | 2004 | The European Journal of Heart Failure2004，，6： | 1 |
| 13 | Application of NT-proBNP and BNP measurements in cardiac care:a more discerning marker for the detection and evaluation of heart failure显示文摘 | Akio Ogawa Teruyo Yamashita | 2004 | Euro J Heart Failure2004，6，： | 1 |
| 14 | Application of NT-proBNP and BNP measurement sin cardiac care:a more dis-ceming marker fort he detection and evaluation of heart fail-ure显示文摘 | Yoshihiko S Akio O Teruyo Y | 2004 | Eur J Heart Fail2004，6，： | 1 |
| 15 | Application of NT-proBNP and BNP meas-urements in cardiac care : a more discerning marker for the detec-tion and evaluation o f heart failure 显示文摘 | Yoshihiko S Teruyo Y | 2004 | Eur J Heart Failure2004，39，7： | 1 |
| 16 | Application of NT-proBNP and BNP measurements in care: a more discerning marker for the detection and evaluation of heart faiIure显示文摘 | YOSHIHIKO S TERUYO Y et at | 2003 | European heart Fail2003，12，： | 1 |
| 17 | Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome显示文摘 | Takumi Taniguchi Yuichi Koido Jyunichi Aiboshi Teruyo Yamashita Shinichiro Suzaki Akira Kurokawa | 1999 | Critical Care Medicine1999，，7： | 1 |
| 18 | Structural comparison of three types of Staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus 显示文摘 | Yuki Katayama Kazumi Asada | 2001 | Antimicrob Agents and Chemother2001，45，5： | 1 |
| 19 | Application of NT-proBNP and BNP measurements in cardiac care:a more discerning marker for the detection and evaluation of heart failure显示文摘 | Yoshihiko S Akio O Teruyo Y | 2004 | Eur J Heart Fail2004，6，3： | 1 |
| 20 | Comparison of methicillin-resistant Staphylococcus aureus strains isolated in 2003 and 2008 with an emergence of multidrug resistant ST22: SCC mec IV clone in a tertiary hospital, Malaysia显示文摘 | King Ting Lim Yasmin Abu Hanifah Mohd Yasim Mohd Yusof Teruyo Ito Kwai Lin Thong | 2013 | Journal of Microbiology, Immunology and Infection2013，，3： | 1 |
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