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| 1 | Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%. | ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab | 2017 | World Journal of Gastroenterology2017，23，38： | 15 |
| 2 | Post-endoscopic retrograde cholangiopancreatography pancreatitis: Risk factors and predictors of severity显示文摘AIM To detect risk factors for post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) and investigate the predictors of its severity.METHODS This is a prospective cohort study of all patients who underwent ERCP.Pre-ERCP data,intraoperative data,and post-ERCP data were collected.RESULTS The study population consisted of 996 patients.Their mean age at presentation was 58.42(± 14.72) years,and there were 454 male and 442 female patients.Overall,PEP occurred in 102(10.2%) patients of the study population; eighty(78.4%) cases were of mild to moderate degree,while severe pancreatitis occurred in 22(21.6%) patients.No hospital mortality was reported for any of PEP patients during the study duration.Age less than 35 years(P = 0.001,OR = 0.035),narrower common bile duct(CBD) diameter(P = 0.0001) and increased number of pancreatic cannulations(P = 0.0001) were independent risk factors for the occurrence of PEP.CONCLUSION PEP is the most frequent and devastating complication after ERCP.Age less than 35 years,narrower median CBD diameter and increased number of pancreaticcannulations are independent risk factors for the occurrence of PEP.Patients with these risk factors are candidates for prophylactic and preventive measures against PEP. | Ayman El Nakeeb Ehab El Hanafy Tarek Salah Ehab Atef Hosam Hamed Ahmad M Sultan Emad Hamdy Mohamed Said Ahmed A El Geidie Tharwat Kandil Mohamed El Shobari Gamal El Ebidy | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 10 |
| 3 | 制备宽温区O/W微乳的新方法(英文)显示文摘报导了一个利用离子和非离子表面活性剂复配制备对温度不敏感的水包油微乳的新方法.该方法通过把一个带有羧基的离子表面活性剂镶嵌在微乳界面的单分子层中 ,在低 pH值时 ,形成水包油微乳 ,然后用氢氧化钠中和使其表面离子化而形成一个较厚的双电层 ,从而得到的宽温区 (0 -90℃ )水包油微乳.研究了油相浓度、pH以及微乳液滴的大小对体系的浊点的影响 ,提出了一个解释宽温区水包油微乳形成的可能机理. | 梁文平 Tharwat F Tadros | 2000 | 物理化学学报2000，16，6： | 9 |
| 4 | Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients显示文摘AIM: To evaluate the safety and the efficacy of the ultrasound ciliary plasty(UCP) on the intraocular pressure(IOP) control in glaucomatous eyes without previous glaucoma surgery.METHODS: A retrospective study included patients with primary and secondary glaucoma who underwent UCP in Dar Al Shifa Hospital, Kuwait between January 2017 to June 2018. High-intensity focused ultrasound procedures were performed under peribulbar anesthesia using the 2^(nd) generation probe with 8 s duration of each of the 6 shots. Complete ophthalmologic examinations were scheduled pre-treatment, and at 1 d, 1 wk, 1, 3, 6 and 12 mo posttreatment. Primary outcomes were the IOP reduction and success rates at 12 mo, while the secondary outcomes were the occurrence of vision threatening complications and visual acuity.RESULTS: The records of 62 eyes of 62 patients were analyzed with mean age of 63.8 y(67.7% males). There was statistically significant reduction in the mean IOP from 35.2±8.3 mm Hg before treatment to 20.6±8.7 mm Hg at 12^(th) month(P<0.0005) with a mean percentage IOP reduction of 42.3% with significant reduction in the mean number of antiglaucomatous drugs from 3.2±0.4 before treatment to 2.1±1.02 at 12 mo(P<0.0005). Qualified success was achieved in 77.4% of eyes at 12 mo. No major intra-or posttreatment complications were reported.CONCLUSION: Second-generation UCP prove to be effective in reducing IOP in naive glaucoma patients with lower success rates in cases of neovascular and uveitic glaucomas. | Magda A.Torky Yousif A Al Zafiri Sherein M.Hagras Abeer M.Khattab Rania M.Bassiouny Tharwat H.Mokbel | 2019 | International Journal of Ophthalmology(English edition)2019，12，4： | 9 |
| 5 | Intraoperative endoscopic retrograde cholangiopancreatography: A useful tool in the hands of the hepatobiliary surgeon显示文摘AIM: To evaluate the efficacy of intraoperative endoscopic retrograde cholangio-pancreatography(ERCP) combined with laparoscopic cholecystectomy(LC) forpatients with gall bladder stones(GS) and common bile duct stones(CBDS).METHODS: Patients treated for GS with CBDS were included. LC and intraoperative transcystic cholangiogram(TCC) were performed in most of the cases. Intraoperative ERCP was done for cases with proven CBDS.RESULTS: Eighty patients who had GS with CBDS were included. LC was successful in all cases. Intraoperative TCC revealed passed CBD stones in 4 cases so intraoperative ERCP was performed only in 76 patients. Intraoperative ERCP showed dilated CBD with stones in 64 cases(84.2%) where removal of stones were successful; passed stones in 6 cases(7.9%); short lower end stricture with small stones present in two cases(2.6%) which were treated by removal of stones with stent insertion; long stricture lower 1/3 CBD in one case(1.3%) which was treated by open hepaticojejunostomy; and one case(1.3%) was proved to be ampullary carcinoma and whipple's operation was scheduled. CONCLUSION: The hepatobiliary surgeon should be trained on ERCP as the third hand to expand his field of therapeutic options. | Ayman El Nakeeb Ahmad M Sultan Emad Hamdy Ehab El Hanafy Ehab Atef Tarek Salah Ahmed A El Geidie Tharwat Kandil Mohamed El Shobari Gamal El Ebidy | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 6 | Long-term results of Ahmed glaucoma valve implantation in Egyptian population显示文摘AIM: To evaluate the long-term results and complications of Ahmed glaucoma valve(AGV) implantation in a cohort of Egyptian patients.METHODS: A retrospective study of 124 eyes of 99 patients with refractory glaucoma who underwent AGV implantation and had a minimum follow-up of 5 y was performed. All patients underwent complete ophthalmic examination and intraocular pressure(IOP) measurement before surgery and at 1 d, weekly for the 1 st month, 3, 6 mo,and 1 y after surgery and yearly afterward for 5 y. IOP was measured by Goldmann applanation tonometry and/or Tono-Pen. Complications and the number of anti-glaucoma medications needed were recorded. Success was defined as IOP less than 21 mm Hg with or without anti-glaucoma medication and without additional glaucoma surgery. RESULTS: Mean age was 23.1±19.9 y. All eyes had at least one prior glaucoma surgery. IOP was reduced from a mean of 37.2±6.8 to 19.2±5.2 mm Hg after 5 y follow-up with a reduced number of medications from 2.64±0.59 to 1.81±0.4.Complete and qualified success rates were 31.5% and 46.0%respectively at the end of follow-up. The most common complications were encapsulated cyst formation in 51 eyes(41.1%), complicated cataract in 9 eyes(7.25%), recessed tube in 8 eyes(6.45%), tube exposure in 6 eyes(4.8%) and corneal touch in 6 eyes(4.8%). Other complications included extruded AGV, endophthalmitis and persistent hypotony.Each of them was recorded in only 2 eyes(1.6%). CONCLUSION: Although refractory glaucoma is a difficult problem to manage, AGV is effective and relatively safe procedure in treating refractory glaucoma in Egyptian patients with long-term follow-up. Encapsulated cyst formation was the most common complication, which limits successful IOP control after AGV implantation.However, effective complications management can improve the rate of success. | Eman Elhefney Tharwat Mokbel Waleed Abou Samra Hanem Kishk Tarek Mohsen Amr El-Kannishy | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 4 |
| 7 | Pentacam changes in primary angle-closure glaucoma after different lines of treatment显示文摘AIM: To assess the changes in the anterior chamber parameters using Pentacam following four different lines of treatment of primary angle-closure glaucoma(PACG).METHODS: A retrospective comparative study included 126 patients(126 eye) presented within 24-48 h after acute angle-closure glaucoma(AACG). Patients were divided into 2 groups: group A(68 eyes) with controlled intraocular pressure(IOP) ≤21 mm Hg, which included subgroup A1(34 eyes) with clear lens underwent Nd:YAG laser peripheral iridotomy(LPI) and subgroup A2(34 eyes) with cataract underwent standard phacoemulsification;and group B(58 eyes) with uncontrolled IOP, which included subgroup B1(30 eyes) with clear lens underwent trabeculectomy and subgroup B2(28 eyes) with cataract underwent combined phacoemulsification and trabeculectomy. Patients were fol owed up for at least 3 mo. Primary outcomes were Pentacam anterior segment measurements [anterior chamber angle(ACA) and depth(ACD)]. Secondary outcomes were changes in IOP, visual acuity(VA) and recorded complications. RESULTS: At the 3^(rd)month, there was significant increase in the ACA values in all studied groups compared to preoperative values(P<0.001). The highest percent of increase in ACA was recorded in phacotrabeculectomy group B2(128.40%). There was significant increase in ACD values at 3^(rd)month compared with baseline values(P<0.001) for groups A1, A2, and B2;without change in B1 trabeculectomy group. The maximum deepening of ACD was noticed in group B2 with 94.27% increase. Significantdecrease in postoperative IOP in groups A2, B1 and B2(P<0.001, P=0.014, and P<0.001 respectively). In group A1 there was significant increase in 3^(rd)month postoperative IOP from baseline values(P<0.001). The maximum decrease in IOP was noticed in group B2 with 59.54% decrease. VA improvement in 3^(rd)month postoperative was recorded in all studied groups, maximum VA improvement was observed in group B2 up to 0.2 log MAR.CONCLUSION: Pentacam can be a helpful tool in studying and comparing the effect of the different lines of management of PACG on the anterior chamber measures. Phacotrabeculectomy was proved to be an effective line for managing PACG with resultant significant increase in the anterior chamber parameters, IOP reduction as well as maximum VA improvement. LPI has only temporary effect on IOP with significant changes in ACA and ACD. Phacoemuslification alone can be an option in treating PACG. Trabeculectomy resulted in temporary increase in the anterior chamber parameter which subsequently returned to baseline values. | Tharwat HMokbel Abd-Elmonem Elhesy Ahmed Alnagdy Mohammed FElashri Ahmed MEissa Walid MGaafar Sherein MHagras | 2020 | International Journal of Ophthalmology(English edition)2020，13，4： | 4 |
| 8 | Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients显示文摘AIM: To evaluate the effect of prophylactic administration of nepafenac in prevention of macular edema occurring in diabetic patients after phacoemulsification and to investigate the correlation between optical coherence tomography(OCT) foveal thickness and multifocal electroretinogram(MF-ERG) parameters.METHODS: The study included two groups. Group 1 included 50 diabetic patients with senile cataract(50 eyes, 30 females, 20 males, aged 55±7 y) received nepafenac 0.1% eye drop. Group 2 included another 50 diabetic patients with senile cataract(50 eyes, 22 female, 28 males, aged 53.8±8 y) did not receive nepafenac. All patients were followed up for 3 mo postoperatively. OCT and MF-ERG were done preoperative and at 1 wk, 1, 2 and 3 mo.RESULTS: The mean foveal thickness was statistically significantly lower in Group 1. Five eyes in Group 2 developed clinical cystoid macular oedema(CMO)(10%), and no patients in Group 1 developed central macular thickening more than 50 μm. There were insignificant differences in MF-ERG amplitudes and latencies between the two groups except in the five eyes that developed CMO, there statistically significant reduction of MF-ERG amplitude with increase in foveal thickness. CONCLUSION: Perioperative nepafenac reduces the incidence of CMO following uncomplicated phacoemulsification significantly. Nepafenac has no side effects. | Tharwat Mokbel Sameh Saleh Mona Abdelkader Sherief E.El-khouly Waleed Abou Samra Mohamed Mamdouh | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 3 |
| 9 | 稳定性的控制——浓悬浮液的絮凝作用与流变性质显示文摘许多工业应用部门经常会遇到浓的固-液分散体系(悬浮液),如颜料、染料、印刷油墨、陶瓷品、医药和农药,它们可以是水体系或非水体系,其中分散相可能是有机物或无机物,其质点的尺寸范围很广,从胶体(1毫微米~1微米)到超过1微米甚至几十微米的粗悬浮体。在悬浮液的制备与应用过程中,要控制其性质是困难的,需控制质点间的相互作用也即控制体系的流动特性(流变性)。这些因素决定体系三维结构的形成。在浓悬浮液中。 | Tharwat F.Tadros 晓东 | 1993 | 农药译丛1993，15，4： | 2 |
| 10 | 农药胶悬剂物理稳定性的控制和评定显示文摘 | Tharwat F.Tadros 许圭南 | 1980 | 农药工业译丛1980，6，6： | 2 |
| 11 | 农药胶悬剂的物理稳定性的控制和评定显示文摘 | Tharwat F.Tadros 许圭南 | 1980 | 农药译丛1980，，6： | 2 |
| 12 | The role of antifungal therapy in the prevention of recurrent allergic fungal rhinosinusitis after functional endoscopic sinus surgery: a randomized, controlled study显示文摘 | Khalil Y Tharwat A Abdou AG | 2011 | Ear Nose Throat J2011，90，8： | 1 |
| 13 | Application of rheology for assessment and prediction of the long-term physical stability of emulsions显示文摘 | Tharwat Tadros | 2004 | Advances in Colloid and Interface Science2004，，： | 1 |
| 14 | Combined posterior bumbar plexus sciatic nerve block versus combined femoral obturator sciatic nerve block for ACL reconstruction显示文摘 | Ayman I Tharwat | | 0，，： | 1 |
| 15 | Childhood glaucoma profile in Dakahelia, Egypt: a retrospective study显示文摘AIM: To analyze childhood glaucoma regarding its demographics, presentations, different causes and surgical modalities used among patients in Dakahelia and to apply the Childhood Glaucoma Research Network(CGRN) classification retrospectively to evaluate its convenience.METHODS: A retrospective study in which the medical files of all glaucoma patients <16 years old presented to Mansoura Ophthalmic Center, Mansoura University from 2014 to 2017, were retrieved and analyzed. Collected data included: age, gender, laterality, visual acuity(VA), refraction, intraocular pressure(IOP), corneal diameter, cup-disc ratio, types and number of surgeries and antiglaucomatous drugs(AGD) at the first and last visit. Prevalence of different subtypes was calculated and means of clinical features were compared.RESULTS: A total of 305 eyes of 207 patients were included classified into 6 groups: primary congenital glaucoma(PCG), juvenile open angle glaucoma(JOAG), glaucoma associated with systemic disease, glaucoma associated with ocular anomalies, acquired glaucoma and glaucoma following cataract surgery. PCG was the predominant type(55.1%) followed by acquired glaucoma(29.5%). Males represented 63.8% of the whole studied patients. Glaucoma associated with ocular anomaly group showed the youngest age at diagnosis(21.9±30.0 mo). The shortest corneal diameter was recorded in post cataract group(10.4±0.5 mm). Highest cup-disc ratio was found in the PCG group(P<0.0005). Glaucoma associated with systemic disease presented with the highest baseline IOP(34.5±5.0 mm Hg). All the cases with PCG were treated surgically with 21.8% required more than one surgery. The majority of the patients(74.2%) in the acquired group were treated medically. Combined trabeculotomy-trabeculectomy was the most frequent operation done, accounting for 34.5% of all primary surgeries. Ahmed valve implantation comprised 87% of the secondary surgeries. Acquired glaucoma group had the highest percent of eyes with good final Snellen's VA(69.4%), while glaucoma associated with ocular anomaly group had poorest final VA. CONCLUSION: PCG is the most prevalent type of childhood glaucoma, followed by acquired glaucoma especially traumatic hyphema. Combined trabeculotomytrabeculectomy and Ahmed valve implantation are the most common surgical interventions. CGRN classification is found to provide a consensus skeleton and is recommended to be integrated in our routine ongoing clinical practice. | Tharwat H.Mokbel Eman M.El Hefney Sherein M.Hagras Ahmed A.ALNagdy Amani E.Badawi Manal A.Kasem Shereen M.El Shaer | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 1 |
| 16 | Catalytic chemical amide synthesis at room temperature: one more step toward peptide synthesis显示文摘 | Tharwat M E1 D William E Yohann B | 2015 | J Org Chem2015，80，19： | 1 |
| 17 | Polymeric surfactants in disperse systems 显示文摘 | THARWAT T | 2009 | Adv Colloid Interface Sci2009，，： | 1 |
| 18 | Application of Rheology for Assessment andPrediction of the Long-term Physical Stability of Emulsions 显示文摘 | THARWAT T | 2004 | Advances in Colloid and Interface Science2004，，： | 1 |
| 19 | Transabdominal ultrasonographic appearance of the gastrointestinal viscera of healthy camels ( Camelus dromedaries )显示文摘 | Mohamed Tharwat Fahd Al-Sobayil Ahmed Ali Sébastien Buczinski | 2012 | Research in Veterinary Science2012，，2： | 1 |
| 20 | Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol显示文摘 | Badawy A Mosbah A Tharwat A | 2009 | Fertil Steril2009，92，1： | 1 |
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